Lateralized Changes in Regional Cerebral Blood Flow during Performance of Verbal and Facial Recognition Tasks: Correlations with Performance and “Effort”

Functional neuroimaging has been used to investigate neural substrates of mnemonic processes, and cerebral blood flow (CBF) measures have been sensitive to activation with memory tasks. Studies of memory with two-dimensional¹³³Xenon clearance techniques found that word and face recognition tasks produced contralateral CBF changes in mid-temporal cortical regions. This study replicated the activation paradigm, expanding to the three-dimensional resolution of positron emission tomography (PET). Word and face recognition, and a control baseline task were administered to 19 healthy right-handed volunteers (11 men, 8 women) during successive 10 min PET¹⁵O-water measures of CBF. Quantitative CBF rates were calculated with the arterial input function and the equilibrium model. Redistributions of blood flow were compared across tasks using both absolute and relative (region/whole brain) CBF.Replicating the¹³³Xenon clearance findings, CBF was “appropriately” lateralized during task performance (left–right for words > left–right for faces) in the mid-temporal region. Contrary to predictions, the recognition tasks did not activate expected mesolimbic or prefrontal areas. The task-induced CBF changes also correlated with performance. Bilateral CBF in mid-temporal and parahippocampal gyrus regions of interest correlated with the ability to correctly identify word targets (sensitivity). Left-lateralized CBF in the amygdala and hippocampus correlated with better word sensitivity as well as specificity (ability to correctly reject foils). Complementally, right-lateralized CBF in the parahippocampal gyrus correlated with better face specificity performance. In addition, left-lateralized CBF in the amygdala and right-lateralized CBF in the parahippocampal gyrus and hippocampus correlated with “mental effort” indices (task performance relative to basal ability) for word and face memory tasks, respectively. Thus, whereas this recognition task showed the expected lateralized increase in the mid-temporal region and not in frontal and limbic areas, lateralized activation in some of these areas was associated with better performance. Exploratory analyses on other regions showed lateralized changes in one additional temporal region, the occipital-temporal, and several limbic regions.     

Dissociation between Categorical and Coordinate Spatial Computations: Modulation by Cerebral Hemispheres, Task Properties, Mode of Response, and Age

Kosslyn suggested a dissociation of two kinds of spatial representations: categorical and coordinate, the former computed by the left hemisphere and the latter by the right hemisphere. In addition, with practice, a “categorization” of the coordinate computation would appear. These suggestions resulted largely from an experiment, replicated by others, in which the subjects had to estimate the relative position of a dot and a line by giving an oral response, and feedback was provided. The present series of five experiments was an attempt to test whether this finding could be generalized, under several methodological manipulations, some of which have already been used by researchers in separate studies. In the five experiments, accuracy was a more contributive dependent variable than correct latencies, and practice effects on the task × field interaction were not verified. Experiments 1–3 concerned the kind of response. When a manual instead of an oral response was required (Experiment 1;n= 32 Ss), the expected dissociation was observed (as well as when the latency of responses made by the right hand were studied). When the number of oral responses was increased from two (a binary choice) to eight, the dissociation was still observed for accuracy but disappeared when a more liberal criterion of accuracy was used to reduce the considerable task effect (Experiment 2;n= 32 Ss), or when response requirements were equated for both tasks (Experiment 3;n= 32 Ss). In Experiment 4 (n= 32 Ss), a manual response was called but the feedback was removed and the task dissociation disappeared. Finally, the task dissociation observed in Experiment 1 was not verified when a sample of elderly subjects was enrolled (Experiment 5;n= 32 Ss). However, age per se was the source of an interesting additional dissociation since only the coordinate computation was age sensitive. Our results suggest that the dissociation proposed by Kosslyn between the computation of categorical vs coordinate spatial relationships is highly unstable and sensitive to subtle methodological factors (vocal vs manual response, presence vs absence of feedback, binary vs “continous” response, age) which could preclude its general application.     

Reading performance and general cognitive ability in twins with reading difficulties and control pairs

The etiology of the observed relationship between general cognitive ability and reading performance was investigated by analyzing data from samples of twin pairs tested in the Colorado Learning Disabilities Research Center. Bivariate phenotypic and genetic structural equation models were fitted to data from 486 twin pairs selected for reading deficits (276 identical and 210 same-sex fraternal) and 314 control pairs (195 identical and 119 same-sex fraternal). Subtests of the Peabody Individual Achievement test (Reading Recognition, Reading Comprehension, and Spelling) were used as measures of reading performance, and verbal and performance IQ scores from the Wechsler Intelligence Scale for Children-Revised (WISC-R) or Wechsler Adult Intelligence Scale-Revised (WAIS-R) were used as indices of general cognitive ability. The results of these confirmatory factor analyses indicate that shared environmental influences do not contribute significantly to covariation between general cognitive ability and reading performance. In contrast, genetic influences contribute substantially to the relationship between the two latent factors. Moreover, the genetic and phenotypic variances of reading performance in the proband group are larger than those in controls, whereas both the genetic and phenotypic correlations between reading performance and general cognitive ability are lower in probands. These results are consistent with recent reports that reading disability may be caused by one or more genes with major effects.     

Can Planck's constant be measured with classical mechanics?

An interesting case of the complex interaction between theory and experiment can be found in many experiments in quantum physics employing classical reasoning. It is expected that this practice would lead to quantitative inaccuracy, unless the measurements’ results were averaged. Whether or not this inaccuracy is significant depends critically on the details of the particular experimental situation. The example of Millikan's photoelectric experiment, in which he obtained a precise value of Planck's constant, provides a good case for illustrating the process of estimating the inaccuracy resulting from the classical‐quantum discrepancy. In the case of Millikan's experiment, it seems that a significant inaccuracy was avoided because of fortunate coincidences. In general, in the absence of a careful analysis, it is impossible to say whether the use of classical reasoning interferes with the accuracy of a quantum‐physical experiment.     

The nature and treatment of social phobia in youth

A small proportion of children and adolescents experience a debilitating level of social anxiety, known as social phobia. Initially, we consider the phenomenology and aetiology of social phobia in children and adolescents. A number of age-sensitive assessment instruments or tools are briefly considered: a diagnostic interview, selj-report instruments, behavioural observations, cognitive assessment, self-monitoring and psychophysiological recording. We explore cognitive-behavioural strategies that have been found to be useful in the management of social phobia. Although there is much research support for the efficacy of cognitive-behavioural strategies for adults with social phobia, it is emphasized that controlled evaluations have yet to be undertaken with socially phobic youngsters.     

Socialization in an International Context

The globalization of the world economy, the widespread expansion of corporations into overseas markets and the increased use of expatriate and repatriate job assignments have all fundamentally changed the context in which organizational socialization now takes place. This article examines the distinctive socialization issues made salient by this organizational context change. The paper reviews existing theoretical and empirical research, provides hypotheses to guide future socialization research in this area and discusses the implications of an international context for the management of organizational socialization programmes.     

Should the behavioral sciences become more pragmatic? The case for functional contextualism in research on human behavior

Although societal need for behavioral science research is enormous, current research practices seem to be inefficient vehicles for producing knowledge that guides practical action. Many of our most popular theories provide little direct guidance for application. They focus on the development of models of the relationships among organismic events such as attitudes, self-efficacy expectations, and behavior, but pay little or no attention to the contextual influences on behavior. Such research is in keeping with a long-standing mechanistic tradition in psychology. We propose a version of contextualism as an alternative paradigm for the behavioral sciences. According to this paradigm, theories and research are evaluated in terms of their contribution to the prediction and influence of behavior. Basic research organized to pursue this goal has a direct bearing on how behavioral phenomena can be changed for practical purposes. Conversely, applied research contributes to basic understanding of the determinants of psychological phenomena.     

DIRECT AND COLLATERAL EFFECTS OF RESTRAINTS AND RESTRAINT FADING

Mechanical restraints are commonly used to reduce the risks associated with severe self-injurious behavior (SIB), but may result in movement restriction and adverse side effects (e.g., bone demineralization). Restraint fading may provide a method for decreasing SIB while increasing movement and reducing these side effects. In the current investigation, rigid arm sleeves and restraint fading (gradually reducing the rigidity of the sleeves) were used with 3 clients who engaged in hand-to-head SIB. Restraints and fading reduced the hand-to-head SIB of all clients. However, for 1 client, the addition of a water mist procedure further reduced SIB to near-zero levels. For a 2nd client, another form of SIB developed that was not prevented by the rigid sleeves. For a 3rd client, a topography of SIB that was not physically prevented by the rigid sleeves was also reduced when restraints and fading were introduced.     

Foraging for brain stimulation: toward a neurobiology of computation

The self-stimulating rat performs foraging tasks mediated by simple computations that use interreward intervals and subjective reward magnitudes to determine stay durations. This is a simplified preparation in which to study the neurobiology of the elementary computational operations that make cognition possible, because the neural signal specifying the value of a computationally relevant variable is produced by direct electrical stimulation of a neural pathway. Newly developed measurement methods yield functions relating the subjective reward magnitude to the parameters of the neural signal. These measurements also show that the decision process that governs foraging behavior divides the subjective reward magnitude by the most recent interreward interval to determine the preferability of an option (a foraging patch). The decision process sets the parameters that determine stay durations (durations of visits to foraging patches) so that the ratios of the stay durations match the ratios of the preferabilities.