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421.
Stein DJ 《CNS spectrums》2008,13(1):26-30
Panic disorder seems to be mediated by the neuronal circuitry and neurochemical systems that have evolved to respond to external threatening stimuli. Distant threats activate prefrontal cortex (involved in complex planning of avoidance strategies), while immediate threats activate midbrain structures (involved in fast reflexive behaviors). Panic disorder may, however, also involve more specific interoceptive mechanisms. For example, the association between respiratory dysfunction and panic disorder has bolstered a false suffocation alarm hypothesis. Genetic and environmental contributors to panic disorder are beginning to be delineated. Effective pharmacotherapy and psychotherapy are able to normalize the relevant psychobiology.  相似文献   
422.
In addition to his many other personae, Jung was a writer and an author, which means a creator, whose written works underlie and authorize a field of thought and clinical work, i.e., analytical psychology. Not widely recognized is that many of his authored texts were stimulated by important and intense personal relationships. Freud and Victor White loom large, the first standing behind major early analytical texts like Wandlungen und Symbole der Libido and Psychological Types, the second behind later texts on culture, religion, and Christian theology. The publication of The Jung-White Letters reveals the significance of his relationship with Victor White for the authoring of Answer to Job.  相似文献   
423.
Social anxiety disorder (SAD) also know as social phobia is increasingly recognized as a highly prevalent and disabling psychiatric disorder. SAD patients demonstrate cognitive-affective distortions in relation to social situations and abnormal activation patterns in limbic structures during functional imaging. Behavioral inhibition is an endophenotype that may be useful in understanding vulnerability to SAD, and that has specific imaging and genetic correlates. From an evolutionary perspective, it has been speculated that SAD represents a false appeasement alarm. It is notable that SAD responds to selective serotonin reuptake inhibitors and monoamine oxidase inhibitors, but not to most tricyclic antidepressants; this finding is consistent with the importance of serotonin and dopamine in mediating this disorder.  相似文献   
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One fourth to one half of parents of children with attention-deficit/hyperactivity disorder (ADHD) have ADHD themselves, complicating delivery of evidence-based child behavioral and pharmacological treatments. In this article, we review the literature examining the relation between parent ADHD and outcomes following behavioral and pharmacological treatments for children with ADHD. We also review research that has incorporated treatment of parent ADHD (either alone or in combination with child treatment) with the goal of improving parenting and child outcomes. Finally, we offer recommendations for future research on the relation between parent ADHD and evidence-based treatment outcomes for their children, with the purpose of advancing the science and informing clinical care of these families.  相似文献   
427.
Intimate partner violence remains a pervasive and common social problem. Evidence indicates that children witness many instances of intimate partner violence. However, the structure of children’s thinking about family violence is still not well understood. This research employed latent profile analysis to identify underlying latent profiles of children’s thinking about violence using the Attitudes and Beliefs About Violence Scale. The analysis identified two latent profiles mostly differentiated by children’s beliefs about whether or not victims of violence deserve to have violence inflicted upon them. Several covariates differentiated members of the two profiles. Suggestions for intervention and practice are included.  相似文献   
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We present a framework to describe the process of conducting community-based qualitative research. Qualitative research activities are presented as a series of interrelated acts called asking, witnessing, interpreting, and knowing. Each act in the research process is described in terms of current qualitative research practices, and illustrated with examples from our own research projects on families with schizophrenia and men's mutual support and batterer intervention groups. We critically examine the assumption that qualitative research serves to reveal or amplify the voices of participants. We examine connections between qualitative research and social change and describe the use of qualitative research to not only empower marginalized groups, but also to critique and transform privileged groups. The framework is intended to help community researchers to more fully conceptualize, understand, and engage in the practice of qualitative research.  相似文献   
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This study investigated demographic variables, including affected sibling pair status, as risk factors for suicidal behavior in schizophrenia patients of African (Xhosa) descent. Xhosa subjects with schizophrenia were interviewed with the Diagnostic Interview for Genetic Studies (DIGS) and then stratified into two groups: those with ( n = 90) and those without ( n = 364) a history of previous suicide attempts. Demographic parameters (including gender, age, and social circumstances, sib ship) were then compared across these groups. Demographic predictors of suicide included sib ship status ( p = 0.038; OR = 1.7) and age of onset of illness ( p = 0.008; OR = 2.5). On further analysis of suicide in siblings, only a minority of sib pairs was found to be concordant for a lifetime history of suicide attempts (3%). These findings raise the possibility that affected sib pair status may be protective in nature. Given the counter-intuitive nature of this finding, further work is needed to replicate it, and to explore possible underlying mechanisms.  相似文献   
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