Path model of multidimensional compliance with cancer therapy

Patients newly diagnosed with hematologic malignancies were followed for a 6-month treatment period to assess compliance with three regimen requirements for cancer therapy: anti-neoplastic medication self-administered intermittently, supportive medication self-administered daily, and monthly clinic appointments. The effect on compliance of three intervention "packages" (some combination of education, shaping of pill-taking behavior, and home restructuring) and the extent that patient satisfaction, knowledge, and uncertainty about illness-related events mediated the effects of the interventions were also examined. Blood levels of the drugs and self-report measures indicated that compliance with daily pill taking was higher for each intervention group compared to a control group. Similar results were obtained for compliance with clinic appointments. No improvement in intermittent self-medication was found. Although each intervention package increased patient knowledge and satisfaction, path analyses demonstrated that knowledge did not affect any aspect of compliance, whereas satisfaction was associated with increased appointment keeping only. Daily pill taking was influenced directly by the behavioral components of the interventions. Uncertainty did not influence compliance but was associated with depression, which was negatively correlated with intermittent self-medication.     

The Maudsley Obsessional-Compulsive Inventory: a psychometric investigation on Chinese normal subjects

The 30-item Maudsley Obsessional-Compulsive Inventory (MOCI) was administered to 183 normal English-speaking Chinese subjects. The inventory achieved modest to relatively low internal consistency as a scale and as four subscales. Three independent dimensions of obsessional complaints interpretable as Perfectionistic and Repetitive Checking, Fear of Contamination, and Doubting Rumination emerged in the factor analysis of item responses. While the first factor corresponded to the Checking component, the second to the Cleaning component, the third was reminiscent of the Doubting, Ruminating and Slowness components. The responses to the MOCI were also explored in their correlations with depression and assertiveness. These results were discussed in in terms of the development of a refined and shortened version of the MOCI and their implications for developing differential treatment models for obsessive-compulsive patients.     

Reduced lateralization in verbal dichotic listening in adolescent psychopaths

One possible explanation for previous findings of abnormal linguistic processing in psychopaths is that they are less lateralized for verbal processes. This study tests the hypothesis that adolescent psychopaths show evidence of reduced lateralization on a verbal dichotic listening task. Four self-report and behavioral measures of psychopathy were used to define psychopathy using cluster analytic techniques in 40 juvenile offenders aged 13 to 18 years. Psychopaths were found to have reduced ear asymmetries relative to nonpsychopaths, a result indicating reduced lateralization for verbal material. The effect does not appear to be mediated by group differences in age, ethnic background, IQ, overall performance, left-handedness, selective attention to one ear, or interhemispheric transfer deficits. This result suggests that the previous finding by Hare and McPherson is robust, provides some preliminary validity for the assessment of psychopathy before age 18, and indicates initial support for the utility of cluster analytic techniques in the assessment of psychopathy.     

Family work for schizophrenia: some issues for Chinese immigrant families

This paper discusses some specific issues relevant to immigrant Chinese families in the context of family work for schizophrenia. The issues include shame and guilt, isolation and mistrust of officials, the importance of negotiation before details of problem-solving are worked out, high academic ambitions for children, and apparent ‘overprotectiveness’ in the Chinese culture. It is argued that cognitive-behavioural, goal-orientated family work could be adapted well for immigrant Chinese families with a member suffering from schizophrenia. A case study is presented to illustrate how such a family was helped.     

The effect of density and diameter on haptic perception of rod length

Three experiments on the effect of density and diameter on haptic perception of rod length are reported. In Experiment 1, the subjects wielded visually occluded rods of different densities. Perceived length was found to be affected by the density of the rod regardless of the actual length. In Experiment 2, three aluminum rods of different lengths with handles of four different diameters were wielded. Perceived length of the rod was found to be shorter as the diameter of the handle with which it was wielded increased. A diameter—length illusion was thereby produced. In Experiment 3, visually occluded rods of different diameters but of the same moment of inertia about thex-axis were wielded with the right hand, and tubes of different diameters were felt with the left hand. The subjects were instructed that their right hand was grasping a handle, and that the actual diameter of the rod could be felt with the left hand. Rods were perceived to be shorter if a larger diameter was felt with the left hand. The results showed that perceived length is not just a function of actual rod length, and that it is not accounted for by inertia only. The results are further discussed in terms of the nature of invariants and the effect of knowledge on perception.     

Haptic perception of partial-rod lengths with the rod held stationary or wielded

Three experiments on the haptic perception of partial-rod lengths are reported. The rods were gripped between the two ends and held horizontal. The subjects held the rods stationary; the distribution of mass of the segment in front of the hand was fixed, while the distribution of mass of the segment behind the hand was varied. Perceived forward length was found to be significantly affected by the distribution of mass of the backward segment. Similar results were obtained when the rods were wielded. The results indicated that partial-rod lengths are specified by functions of mechanical perturbations acting on the hand, and not ay the breaking up of the first moment of mass or the moment of inertia of the rod by attention as suggested previously by others. The results are also discussed with respect to invariant detection and attention.     

Developing Measures of Basic Job-Relevant English Proficiency for the Prediction of Job Performance and Promotability

The present study is an attempt to devise reliable and valid measures of job-relevant basic English proficiency to be applied in the prediction of job performance and promotability in an entry-level manual labor job dominated by workers whose native language is not English. An audio test and a reading test were developed to assess the ability to understand spoken English and written English respectively using job relevant material. Results showed that both tests demonstrated high predictive validity for the criteria of supervisory assessments of incumbents' English proficiency on the job, overall job performance, and promotability. In predicting ratings of overall job performance and promotability, each test provided incremental validity over the predictability provided by the other test. In addition, the tests also provided incremental validity in predicting promotability over the predictability provided by overall job performance.     

The development of an Assertiveness Self-Report Inventory

The development of a self-report measure of assertiveness is described. The Assertiveness Self-Report Inventory (ASRI) was devised with concern for endorsement frequency, internal consistency, and independence from social desirability response bias. The scale's reliability and convergent and discriminant validity are adequate. Further tests of validity support the use of the scale as a measure that taps behavior related to the construct of assertiveness.     

Enhanced Hippocampal CA1 LTP but Normal Spatial Learning in Inositol 1,4,5-trisphosphate 3-kinase(A)-Deficient Mice

To define the physiological role of IP₃3-kinase(A) in vivo, we have generated a mouse strain with a null mutation of the IP₃3-kinase(A) locus by gene targeting. Homozygous mutant mice were fully viable, fertile, apparently normal, and did not show any morphological anomaly in brain sections. In the mutant brain, the IP₄ level was significantly decreased whereas the IP₃ level did not change, demonstrating a major role of IP₃3-kinase(A) in the generation of IP₄. Nevertheless, no significant difference was detected in the hippocampal neuronal cells of the wild-type and the mutant mice in the kinetics of Ca²⁺ regulation after glutamate stimulation. Electrophysiological analyses carried out in hippocampal slices showed that the mutation significantly enhanced the LTP in the hippocampal CA1 region, but had no effect on the LTP in dentate gyrus (DG). No difference was noted, however, between the mutant and the wild-type mice in the Morris water maze task. Our results indicate that IP₃3-kinase(A) may play an important role in the regulation of LTP in hippocampal CA1 region through the generation of IP₄, but the enhanced LTP in the hippocampal CA1 does not affect spatial learning and memory.