Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: a 2-[18F]fluoro-A-85380 PET study

Neuronal nicotinic acetylcholine receptors (nAChRs) are critical for higher order cognitive processes. Post-mortem studies suggest reductions in nAChRs (particularly the alpha(4)beta(2) subtype) with ageing and in Alzheimer's disease (AD). This study aimed to; (1) quantify nAChR distribution in vivo with 2-[18F]fluoro-A-85380 (2-FA) in 15 early AD patients compared to 14 age-matched, healthy controls (HC) and (2) correlate nAChR distribution with cognitive performance in both groups. All participants were non-smokers and underwent cognitive testing along with a dynamic PET scan after injection of 200 MBq of 2-FA. Brain regional 2-FA binding was assessed through a simplified estimation of Distribution Volume (DV(S)). The AD group differed significantly from HC on all cognitive measures employed, with impairments on measures of attention, working memory, language, executive function, visuospatial ability, verbal learning and verbal memory (p<.05). Contrary to post-mortem data this study found no evidence of in vivo nAChR loss in early AD despite significant cognitive impairment. Furthermore, no correlation between nAChR and cognitive performance was found for either group. The findings of the current study suggest preservation of nAChRs early in AD supporting previous studies. It is possible that while the clinical 2-FA PET method described here may be insensitive in detecting changes in early AD, such changes may be detected in more advanced stages of the illness.     

DISCREPANCY IN FUNCTIONAL ANALYSIS RESULTS ACROSS TWO SETTINGS: IMPLICATIONS FOR INTERVENTION DESIGN

Functional analyses that were conducted in two settings (playground and classroom) indicated that problem behavior was sensitive to adult attention on the playground and tangible items in the classroom. Attention‐ and tangible‐based interventions were designed based on the results from each of the assessment environments and were compared. The attention‐based intervention was more effective on the playground, and the tangible‐based intervention was more effective in the classroom. Findings are discussed in regards to the generality of functional analysis results across environments.     

Are errors differentiable from deceptive responses when feigning memory impairment? An fMRI study

Previous neuroimaging studies have suggested that the neural activity associated with truthful recall, with false memory, and with feigned memory impairment are different from one another. Here, we report a functional magnetic resonance imaging (fMRI) study that addressed an important but yet unanswered question: Is the neural activity associated with intentional faked responses and with errors differentiable? Using a word list learning recognition paradigm, the findings of this mixed event-related fMRI study clearly indicated that the brain activity associated with intentional faked responses was different to the activity associated with errors committed unintentionally. For intentional faked responses, significant activation was found in the ventrolateral prefrontal cortex, the posterior cingulate region, and the precuneus. However, no significant activation was observed for unintentional errors. The results suggest that deception, in terms of feigning memory impairment, is not only more cognitively demanding than making unintentional errors but also utilizes different cognitive processes.     

冲突与支持影响情侣依恋的文化差异

采用香港和美国的被试,运用亲密关系经历量表、冲突量表和社会支持量表,考察了冲突和支持对于情侣依恋影响的文化差异。结果发现,当以依恋焦虑为因变量时,冲突、支持和文化 × 冲突 × 支持都是显著的预测变量;当以依恋逃避为因变量时,仅文化和文化 × 支持是显著的预测变量。由此可见,文化影响冲突 × 支持与依恋焦虑的关系：在香港,情侣之间的冲突和支持各自对于依恋焦虑的作用在很大程度上相互抵消;在美国,情侣之间冲突的负面影响比支持的积极影响要强,冲突 × 支持越高,依恋焦虑越高。对于依恋逃避,文化差异仅调节支持与依恋逃避的关系：在香港,支持对依恋逃避的影响要比美国强。整个研究表明,对不同类型的情侣依恋,文化的调节作用不同。     

Display polarity, stimulus exposure duration, and visual lobe shape

This study investigated the effects of visual display polarity and stimulus exposure duration on visual lobe shape. Analysis showed that regardless of display polarity and exposure duration combinations tested here, visual lobe contours were slightly irregular and asymmetric, of medium roundness, with a moderately rough boundary, and horizontally elongated with a mean length-width ratio of 1.53. Visual lobes mapped with negative display polarity were significantly rounder, slightly more regular and more symmetric along the vertical axis, compared with those mapped with positive polarity. Under the different polarity conditions, there were no significant differences in visual lobe area, perimeter, boundary smoothness, and elongation. When stimulus exposure duration increased from 200 to 400 msec. and from 200 to 300 msec., there were significant increases in the visual lobe area, perimeter, roundness, boundary smoothness, and regularity. No such changes were found when duration increased from 300 to 400 msec. Exposure durations did not have a significant effect on the shape categories of elongation and horizontal symmetry for the different stimuli. There were no statistically significant interactions between polarity and stimulus exposure duration for any of the lobe shape indexes used here.     

The use of health technology and information: e-learning technological approach.

The Internet is becoming the preferred place for finding information. Millions of people go online in search of health and medical information. Likewise, health care professionals must be able to retrieve and manage information in an efficient, effective manner. The development of health technology and informatics (HTI) has been rapid, yet little is known about the knowledge and attitudes of nursing students with regard to using HTI. Therefore, the objective of the present study was to explore nursing students' knowledge of and attitudes toward using HTI and to use an e-learning workshop to enhance the effective use of HTI. In Phase I, 115 first-year full-time nursing students were invited to complete a 13-item questionnaire regarding knowledge of and attitudes toward computer and Internet use, knowledge of HTI, and attitudes toward the future development of HTI. Participants perceived themselves to be knowledgeable in computer and Internet use, while knowledge of HTI was perceived to be low and attitudes toward the future development of HTI were generally positive. Phase II was an e-learning HTI workshop; topics included an introduction to HTI, examples of HTI in use, and the application and implementation of various HTI projects. There were 30 participants in the E-learning workshop, and their feedback was positive. Nurses and all health care professionals must be prepared to participate in the development of health technology and informatics. Teaching and learning activities should be geared toward mastery of HTI in the nursing education curriculum in order to enhance health care quality and safety.     

Toward a theory of individual differences and leadership: understanding the motivation to lead.

A broad, integrative theoretical framework for understanding the relationship between individual differences and various leader behaviors is presented; it proposes a new individual-differences construct called the motivation to lead (MTL). A large-scale study using 3 samples in different occupational and cultural contexts shows 3 factors underlying MTL, namely, affective-identity, noncalculative, and social-normative MTL. A parsimonious model of antecedents to MTL is developed through hierarchical regression modeling and is cross-validated using confirmatory latent variable modeling. MTL is shown to provide incremental validity over other predictors such as general cognitive ability, values, personality, and attitudes in the prediction of 2 behavioral measures of leadership potential. Findings are discussed with reference to the theoretical framework proposed for understanding individual differences in leader behavior.     

Young and Old Adults' Concerns About Morality and Competence

Two experiments were conducted to examine people's sensitivity to person information from the morality domain (relation-oriented) and the competence domain (task & achievement-oriented). In a lexical decision paradigm, the findings from Experiment 1 showed that younger adults were faster to identify person cues (trait words) from the morality than from the competence domain, especially cues that were related to immorality. Experiment 2 compared the responses of younger and older adults. Despite the slower responses of the older adults, the findings indicated that all participants were faster at identifying cues from the morality domain than from the competence domain, with no age interactions. The results from Experiment 2 also suggested that disparate findings in the literature regarding reaction times to morality/competence cues and valence (positive or negative) were a function of word frequency effects. The findings are discussed in terms of people's chronic concern with the moral aspects of others as invariant across the lifespan, given that the morality domain is where interpersonal costs and threats are most likely to be signaled.     

Indigenization and Beyond: Methodological Relationalism in the Study of Personality Across Cultural Traditions

A brief intellectual history of the indigenization movement in Asia leads to the thesis that the generation of psychological knowledge is culture dependent. Indigenous psychologies go further and insist on viewing a target group from the natives' own standpoint. Psychological decentering underlies conceptions of human existence rooted in Asian intellectual traditions, in particular, relatedness between persons predominates in Confucianism. These conceptions demand new approaches to knowledge generation that signify a paradigmatic shift from methodological individualism to methodological relationalism. An implication is that relationships precede situations in the study of personality and social behavior. We define personality as the sum total of common attributes manifest in, and abstracted from, a person's behavior directly or indirectly observed across interpersonal relationships and situations over time. We rely on the notion that there are identifiable levels of cognition to develop a metatheoretical framework for reconstructing selfhood. Confronting the subject-object dichotomy opens the door to investigations of transcendent consciousness; confronting the self-other demarcation underlying Western theories leads to the construction of self-in-relations.     

Behavioral evidence for task-dependent “what” versus “where” processing within and across modalities

Task-dependent information processing for the purpose of recognition or spatial perception is considered a principle common to all the main sensory modalities. Using a dual-task interference paradigm, we investigated the behavioral effects of independent information processing for shape identification and localization of object features within and across vision and touch. In Experiment 1, we established that color and texture processing (i.e., a “what” task) interfered with both visual and haptic shape-matching tasks and that mirror image and rotation matching (i.e., a “where” task) interfered with a feature-location-matching task in both modalities. In contrast, interference was reduced when a “where” interference task was embedded in a “what” primary task and vice versa. In Experiment 2, we replicated this finding within each modality, using the same interference and primary tasks throughout. In Experiment 3, the interference tasks were always conducted in a modality other than the primary task modality. Here, we found that resources for identification and spatial localization are independent of modality. Our findings further suggest that multisensory resources for shape recognition also involve resources for spatial localization. These results extend recent neuropsychological and neuroimaging findings and have important implications for our understanding of high-level information processing across the human sensory systems.