Review of Commercially Available Epilepsy Genetic Panels

Next generation sequencing panels have revolutionized the diagnostic approach to patients with epilepsy. There are several commercial epilepsy panels available. We assessed the list of genes tested and consent forms for epilepsy panels available at seven laboratories. The panels varied in the number of genes included (70–465 genes). In some panels, genes not currently associated with epilepsy were included (up to 4 % of panel content). The panels also included genes for lysosomal storage disorders (6–12 %), congenital disorders of glycosylation (0–8.5 %), metabolic disorders (3.5–34 %), neurological syndromes (18–43 %) and multisystemic genetic syndromes (6.4–21 %). Informed consents differed significantly between laboratories ranging from basic information about genetic testing and possible results to information about insurance, genetic counseling and familial testing, and incidental findings.Our findings suggest that it is important to consider the range of genes offered on epilepsy panels and their predicted phenotypes in an effort toward improving the informed consent process.     

Four‐model approach to adolescent–parent attachment relationships and adolescents' loneliness,school belonging,and teacher appraisal

This study tested monotropy, hierarchy, independence, and integration conceptual models of adolescent–mother and adolescent–father attachment to explain adolescents' perceived social interrelationships with extrafamilial attachment figures (peers, teachers). Participants included 356 Israeli adolescents (12–15 years). More adolescents were significantly classified as securely attached to mothers than to fathers, but high concordances emerged. Results supported two of the attachment models, hierarchy and integration, as explaining variation in adolescents' perceived extrafamilial interrelationships. As per the hierarchy attachment model, adolescent–mother attachment outweighed adolescent–father attachment to some extent in predicting adolescents' perceived social interrelationship measures. As per the integration attachment model, significant differences emerged on most social interrelationship measures between the 4 distinct subgroups: secure attachment to both parents, neither, only father, only mother. The Discussion section focuses on the unique importance of attachment to each parent for typically developing junior high students.     

WHEN THINKING HESITATES: PHILOSOPHY AS PROSTHESIS AND TRANSFORMATIVE VISION

In this essay, I draw on Henri Bergson and Maurice Merleau‐Ponty to interrogate what philosophy is and how it can continue to think. Though my answer is not reducible to the views of either philosopher, what joins them is an attempt to elaborate philosophy as a different way of seeing. In this light, I propose a view of philosophy as prosthesis—as a means and a way for seeing differently. Rather than a simple tool, philosophy as prosthesis is a transformative supplement, one that our bodily perception calls for and wherein that perception is recast. Rather than a fixed or assured view, this prosthesis holds open the interval in which thinking can take place. Philosophy, I argue, must wait. It sees and thinks hesitatingly, for the temporality it inscribes is not a foreseeable development but the unfolding of life as tendency, as that which creates its own possibility as it comes into existence.     

Conservatives are happier than liberals, but why? Political ideology, personality, and life satisfaction

Political conservatives are happier than liberals. We proposed that this happiness gap is accounted for by specific attitude and personality differences associated with positive adjustment and mental health. In contrast, a predominant social psychological explanation of the gap is that conservatives, who are described as fearful, defensive, and low in self-esteem, will rationalize away social inequalities in order to justify the status quo (system justification). In four studies, conservatives expressed greater personal agency (e.g., personal control, responsibility), more positive outlook (e.g., optimism, self-worth), more transcendent moral beliefs (e.g., greater religiosity, greater moral clarity, less tolerance of transgressions), and a generalized belief in fairness, and these differences accounted for the happiness gap. These patterns are consistent with the positive adjustment explanation.     

Likening stairs in buildings to climbing a mountain: Self-reports of expected effects on stair climbing and objective measures of effectiveness

Objectives

Health promotion agencies advocate use of mountain climbing goals to encourage regular stair climbing, a current public health target. This paper tests effects of a mountain climbing campaign on objective measures of stair use for the first time.

Design

Field interview and quasi-experimental, interrupted time-series study.

Method

In field interviews, a convenience sample (n = 1350) responded to questions about different goals, i.e., heights of climb, to encourage stair use in buildings. Subsequently, a point-of-choice intervention with the main message ‘Take the stairs to the top of this building once a day and in a year, you would have climbed Mount Everest almost twice’ was tested in a 12-floor worksite. A no-message baseline was followed by installation of the intervention.

Results

Stair ascent (n = 62,716) and descent (n = 61,218) at the ground floor was measured with automated counters at baseline (11 days) and during the intervention (18 days). The majority of interviewees (60%) chose a message based on climbing Mt. Everest as the most motivating, with only 5% of interviewees not motivated by any climbing goal. Nonetheless, the subsequent intervention using the mountain climbing goal had no effect on stair climbing (OR = 0.96). As the campaign specifically targeted stair ascent, it failed to influence the behaviour with the greater public health dividend.

Conclusion

The discrepancy between pre-testing and the campaign may reflect the fact that performance goals can only be achieved at the end of the task and may not be continually rewarded during accumulation of behaviour towards the goal.     

Intra-individual variability in gait and in cognitive performance are not related in the elderly

As humans age, the amount of intra-individual variability (IIV) present in both their gait and their cognitive performance tends to increase. Both gait and cognitive IIV are associated with attentional control and with cerebrovascular disease, suggesting that the IIV in gait and cognitive function should be strongly correlated in the elderly. In this study temporal gait variability was determined from a 60-second period of walking. Cognitive variability was determined from two decision-time tasks assessing inhibition. Despite the presence of substantial amounts of gait and cognitive IIV in 71 elderly individuals, there were no significant correlations between measures of cognitive and gait IIV, suggesting that different factors drive IIV in the motor and cognitive performance of older individuals. These results are not consistent with the common cause theory of aging, which predicts that cognitive and sensorimotor performance should show related declines due to age-related disruption of a common neurological substrate.     

How scenes containing visual errors affect speech fluency in young and older adults

We compared young and older adults’ speech during an error detection task, with some pictures containing visual errors and anomalies and other pictures error-free. We analyzed three disfluency types: mid-phrase speech fillers (e.g., It’s a little, um, girl), repetitions (e.g., He’s trying to catch the- the birds), and repairs (e.g., She- you can see her legs). Older adults produced more mid-phrase fillers than young adults only when describing pictures containing errors. These often reflect word retrieval problems and represent clear disruptions to fluency, so this interaction indicates that the need to form and maintain representations of novel information can specifically compromise older adults’ speech fluency. Overall, older adults produced more repetitions and repairs than young adults, regardless of picture type, indicating general age-related increases in these disfluencies. The obtained patterns are discussed in the context of the Transmission Deficit Hypothesis and other approaches to age-related changes in speech fluency.     

The Effects of a Common In‐group Prime on Intentions to Help Indigenous and Homeless Australians

The article reports on research designed to test Australian attitudes towards helping impoverished members of the Australian society, in particular, indigenous and homeless people. Australian university students completed a questionnaire to measure their attitudes towards helping homeless and indigenous people under conditions that primed a common Australian identity. The findings showed that priming an inclusive identity led to relatively stronger intentions to help indigenous Australians but not homeless people. It was also found that participants preferred to endorse more autonomy than dependency help to both indigenous and homeless Australians. Whereas the findings indicate that helping intentions towards those living with poverty may be accentuated by priming a common in‐group, they also imply that helping attitudes vary with the type of help being sought and the way people perceive the cause of someone's poverty.