Reconsolidation of declarative memory in humans

The reconsolidation hypothesis states that a consolidated memory could again become unstable and susceptible to facilitation or impairment for a discrete period of time after a reminder presentation. The phenomenon has been demonstrated in very diverse species and types of memory, including the human procedural memory of a motor skill task but not the human declarative one. Here we provide evidence for both consolidation and reconsolidation in a paired-associate learning (i.e., learning an association between a cue syllable and the respective response syllable). Subjects were given two training sessions with a 24-h interval on distinct verbal material, and afterward, they received at testing two successive retrievals corresponding to the first and second learning, respectively. Two main results are noted. First, the first acquired memory was impaired when a reminder was presented 5 min before the second training (reconsolidation), and also when the second training was given 5 min instead of 24 h after the first one (consolidation). Second, the first retrieval proved to influence negatively on the later one (the retrieval-induced forgetting [RIF] effect), and we used the absence of this RIF effect as a very indicator of the target memory impairment. We consider the demonstration of reconsolidation in human declarative memory as backing the universality of this phenomenon and having potential clinical relevance. On the other hand, we discuss the possibility of using the human declarative memory as a model to address several key topics of the reconsolidation hypothesis.     

Predictors of disclosure of human immunovirus-positive serostatus among Latino gay men

To test a theoretical approach to disclosure of human immunovirus (HIV) status, 301 HIV-positive Latino gay men were interviewed using Audio-CASI (Computer Assisted Self-Interview technology with Audio enhancement). Consequence theory and social influence theory were combined to create a model of antecedents of disclosure. Results provided support for both theories. Perceived positive consequences were associated with greater disclosure to casual partners, families, and friends, whereas perceived negative consequences were associated with less disclosure to friends and family members. Social influence of peer behavioral norms was predictive of disclosure to all three target groups. Gay community social influence produced different effects on disclosure of HIV-positive status: a negative association for casual partners, a positive association for close friends, and no relationship for family members. Time since diagnosis was also predictive of disclosure.     

Multidisciplinary Engagement with Nanoethics Through Education—The Nanobio-RAISE Advanced Courses as a Case Study and Model

This paper presents and evaluates two advanced courses organised in Oxford as part of the European project Nanobio-RAISE and suggests using their format to encourage multidisciplinary engagement between nanoscientists and nanoethicists. Several nanoethicists have recently identified the need for ‘better’ ethics of emerging technologies, arguing that ethical reflection should become part and parcel of the research and development (R&D) process itself. Such new forms of ethical deliberation, it is argued, transcend traditional disciplinary boundaries and require the active engagement and involvement of both nanoethicists and nanoscientists with the broader issues surrounding technological developments. Whereas significant research efforts into multi- and interdisciplinary collaborations during R&D processes are now emerging, opportunities for encouraging multidisciplinary engagement through education have remained relatively underexplored. This paper argues that educational programmes could be a natural extension of ongoing collaborative research efforts ‘in the lab’ and analyses how the Nanobio-RAISE courses could be used as a model for course development. In addition to exploring how the elements that were conducive to multidisciplinary engagement in this course could be preserved in future courses, this paper suggests shifting the emphasis from public communication towards ethical deliberation. Further course work could thus build capacity among both nanoscientists and nanoethicists for doing ‘better’ nanoethics.     

Influence and canonical supremacy: An analysis of how George Herbert Mead demoted Charles Horton Cooley in the sociological canon

This analysis assesses the factors underlying Charles Horton Cooley's place in the sociological canon as they relate to George Herbert Mead's puzzling diatribe—echoed in secondary accounts—against Cooley's social psychology and view of the self published scarcely a year after his death. The illocutionary act of publishing his critique stands as an effort to project the image of Mead's intellectual self and enhance his standing among sociologists within and outside the orbit of the University of Chicago. It expressed Mead's ambivalence toward his precursor Cooley, whose influence he never fully acknowledged. In addition, it typifies the contending fractal distinctions of the scientifically discursive versus literary styles of Mead and Cooley, who both founded the interpretive sociological tradition. The contrasting styles and attitudes toward writing of the two figures are discussed, and their implications for the problems of scale that have stymied the symbolic interactionist tradition are explored.     

Self-controlled concurrent feedback and the education of attention towards perceptual invariants

The present study investigates the effects of different types of concurrent feedback on the acquisition of perceptual-motor skills. Twenty participants walked through virtual corridors in which rhythmically opening and closing sliding doors were placed. The participants aimed to adjust their walking speed so as to cross the doors when the doors were close to their maximal aperture width. The highest level of performance was achieved by learners who practiced the task with unambiguous self-controlled concurrent feedback, which is to say, by learners who could request that feedback at wish. Practice with imposed rather than self-controlled feedback and practice without concurrent feedback were shown to be less effective. Finally, the way in which the self-controlled concurrent feedback was presented was also found to be of paramount importance; if the feedback is ambiguous, it may even prevent participants from learning the task. Clearly, unambiguous self-controlled feedback can give rise to higher levels of performance than other feedback conditions (compared to imposed schedule) but, depending on the way it is presented, the feedback can also prevent the participants from learning the task.In the discussion it is argued that unambiguous self-controlled concurrent feedback allows learners to more rapidly educate their attention towards more useful perceptual invariants and to calibrate the relation between perceptual invariants and action parameters.     

A method for the control of eating rate: A potential intervention in eating disorders

A method for the control of eating rate gave subjects feedback from a computer screen on how much and at what rate to eat during a meal. The method also allowed us to record the development of satiety during the meal. Linear eaters—that is, women selected for eating at an approximately constant rate—underate when challenged to eat at a lower rate and overate when challenged to eat at a higher rate, thereby modeling the eating behavior of patients with anorexia nervosa and binge eating disorder, respectively. In both cases, the women’s postmeal perception of satiety mimicked that of the respective patient group. The results provide support for the notion that linear eaters have the capacity to exhibit disordered eating.     

Flexible use of spatial cues in the southern flying squirrel (<Emphasis Type="Italic">Glaucomys volans</Emphasis>)

Insects, birds, and mammals have been shown capable of encoding spatial information in memory using multiple strategies or frames of reference simultaneously. These strategies include orientation to a goal-specific cue or beacon, to the position of the goal in an array of local landmarks, or to its position in the array of distant landmarks, also known as the global frame of reference. From previous experiments, it appears that birds and mammals that scatter hoard rely primarily on a global frame of reference, but this generalization depends on evidence from only a few species. Here we examined spatial memory in a previously unstudied scatter hoarder, the southern flying squirrel. We dissociated the relative weighting of three potential spatial strategies (beacon, global, or relative array strategy) with three probe tests: transposition of beacon and the rotation or the expansion of the array. The squirrels’ choices were consistent with a spatial averaging strategy, where they chose the location dictated by at least two of the three strategies, rather than using a single preferred frame of reference. This adaptive and flexible heuristic has not been previously described in animal orientation studies, yet it may be a common solution to the universal problem of encoding and recalling spatial locations in an ephemeral physical landscape.     

Processing of Syllables in Production and Recognition Tasks

Empirical evidence for a functional role of syllables in visual word processing is abundant, however it remains rather heterogeneous. The present study aims to further specify the role of syllables and the cognitive accessibility of syllabic information in word processing. The first experiment compared performance across naming and lexical decision tasks by manipulating the number of syllables in words and non-words. Results showed a syllable number effect in both the naming task and the lexical decision task. The second experiment introduced a stimulus set consisting of isolated syllabic and non-syllabic trigrams. Syllable frequency was manipulated in a naming and in a decision task requiring participants to decide on the syllabic status of letter strings. Results showed faster responses for syllables than for non-syllables in both tasks. Syllable frequency effects were observed in the decision task. In summary, the results from these manipulations of different types of syllable information confirm an important role of syllabic units in both recognition and production.     

Social validity of changes in informativeness and efficiency of aphasic discourse following linguistic specific treatment (LST).

This study presents the results of an analysis of pragmatic aspects of language samples obtained from five agrammatic aphasic individuals prior to and following Linguistic Specific Treatment (LST). Clinically and statistically significant positive changes in informativeness and efficiency were documented in posttreatment samples. Analysis of communicative competence (i.e., na?ve listeners' ratings of pre- and posttreatment audiotaped samples), was undertaken to examine the social validity of quantified changes. Mean ratings across listeners were computed to evaluate their subjective perceptions of general communicative constructs. Results indicated that objectively measured changes in pragmatic aspects were perceptible to na?ve listeners, however, to varying degrees across participants and constructs.     

Two Case Studies of Community Schools Serving Latino and Southeast Asian Children

Recent attention has focused on establishing school-based integrated services centers which offer educational and noneducational services to students and their families. We present two comparative case studies of client participation in school centers established in low income Latino and Southeast Asian communities. The cases focus on types of center services utilized by families, culturally compatible practices of the centers, and impact of coordinated services on students and families. The data reveal the limited capacity of high poverty families to cope with daily and persistent life challenges and how the schools have been transformed into family support environments which assist families to manage their lives in ways that lead to self-sufficiency and growth.