A pilot study of urinary peptides as biomarkers for intelligence in old age

Intelligence is an important indicator of physical, mental and social well-being. In old age, intelligence is also associated with a higher quality of life and better health. Heritability studies have shown that there are strong genetic influences, yet unknown, on intelligence, including in old age. Other approaches may be useful to investigate the biological foundations of intelligence differences. Proteomics is a proven technique in revealing biomarkers for certain illnesses. In this pilot study, forty individuals were selected as the cognitive extremes from over 750 people in the Lothian Birth Cohort 1936 (age ~ 72 years) based on their high and low intelligence scores, as measured by a general cognitive ability factor. Urine samples were used as a stable, reliable and abundant source of proteins. Using capillary electrophoresis coupled to mass spectrometry (CE-MS) technology, the proteome of the high and low intelligence groups was determined. Data were calibrated and matched against the human urinary database, to enable comparative assessment. At a nominal significance level (P < 0.05), there were several candidate proteins for association with intelligence, including a zinc finger protein (ZNF653) that has been associated with cognitive deficits, and complement C3 and collagen fragments that have been associated with Alzheimer's disease. Results are preliminary, do not survive multiple testing correction, and require validation. This pilot study shows the potential of this novel proteomics approach, and its applicability to understanding the biological foundations of intelligence differences.     

Temporal patterns of anxious and depressed mood in generalized anxiety disorder: a daily diary study

Research suggests that anxiety disorders tend to temporally precede depressive disorders, a finding potentially relevant to understanding comorbidity. The current study used diary methods to determine whether daily anxious mood also temporally precedes daily depressed mood. 55 participants with generalized anxiety disorder (GAD) and history of depressive symptoms completed a 21-day daily diary tracking anxious and depressed mood. Daily anxious and depressed moods were concurrently associated. Daily anxious mood predicted later depressed mood at a variety of time lags, with significance peaking at a two-day lag. Depressed mood generally did not predict later anxious mood. Results suggest that the temporal antecedence of anxiety over depression extends to daily symptoms in GAD. Implications for the refinement of comorbidity models, including causal theories, are discussed.     

Automated problem solving for the behavioral sciences

In view of the obvious advantages of computers for the behavioral sciences, the question is raised as to how to make more effective use of computing capabilities. One idea is to require that fledgling behavioral scientists receive brief training in flowcharting and algorithm generation rather than a full course in computing skills. Such training would be an important adjunct for those who would go on for further instruction, especially in view of current deficiencies in many computer courses. One recurrent deficiency lies in the lack of specific guidelines for conceptualizing problems for computer implementation. Such guidelines are developed here, along with other suggestions designed to attenuate the difficulty in conceptualization.     

Auditory perception of dissonant polyrhythms

Although the ability of subjects to judge the duration of a temporal interval has been investigated using a variety of paradigms, most of the studies have used very short intervals ranging from a few hundred milliseconds to several seconds. Therefore, the purpose of the present study was to examine the psychophysical relationship between judged and actual durations of longer intervals ranging from months to years. In Experiment 1, college students were asked to estimate the ages of 12 major news events which had occurred during the previous 5 years. Analysis of median estimates of each item showed that subjects underestimated the ages of the oldest items and overestimated the ages of the most recent items. To determine whether this regression effect was due to a response bias or to the context effect produced by other items on the questionnaire, Experiments 2 and 3 systematically varied the range of allowable response alternatives and the age of the background items that formed the context in which the experimental items were judged. Although the range of allowable response alternatives had a significant effect upon the estimates, no evidence was obtained for an item context effect. The data are interpreted in terms of a memory-based hypothesis which suggests that the subjects were attempting to recall the time of occurrence of the items and then deriving elapsed time rather than directly judging duration.     

A programmable multiple-tone generator

A simple tone generator that allows software control of auditory stimuli is described. The circuit provides for the simultaneous generation, timing, and amplification of three different tones. Its low cost, ease of construction, and versatility make it an attractive alternative to conventional auditory stimulus hardware.     

Is age kinder to the initially more able?: differential ageing of a verbal ability in the Healthy Old People in Edinburgh study

Studies that examine whether there is differential age-related decline in intelligence test scores according to initial cognitive status, social class and education are reviewed. We tested the differential ageing hypothesis which states that decline in ability scores over time will be lower in those with superior mental ability, more education and higher social class at the time of original testing. 387 healthy old people were tested at baseline and followed up 4 years later. The National Adult Reading Test (NART) was administered on both occasions. NART-estimated IQ fell by a mean of 2.1 points over 4 years (p<0.001). Subjects in higher social class categories had higher NART scores overall (p<0.001), and had smaller NART decrements over 4 years. Ex-professional and -secretarial groups fell by a mean of 1.4 points in this period, versus 3.2 points for skilled manual, semi-skilled and unskilled groups. In addition, those who fell more in NART were older (p=0.001), were less educated (p<0.001), and had lower NART (p<0.001) scores at baseline. In summary, those with higher baseline ability, in higher social class groups, with more education and who are younger are relatively protected from decline in this verbal ability with age. Possible mechanisms of differential decline in this verbal intelligence with age are discussed.     

Family functioning and psychopathology among adolescents with severe emotional disturbances

Family psychosocial functioning and its relation to psychopathology among adolescents with severe emotional disturbances (SED) was assessed. Subjects were 353 adolescents with SED, ages 12–18, and their parents. During a semistructured interview, adolescents were administered Family Adaptability and Cohesion Evaluation Scale (FACES-III), Diagnostic Interview Schedule for Children-Child Version (DISC-C), and the Self-Derogation Scale. Parents were administered FACES-IIII and the Child Behavior Checklist (CBCL) in a phone interview. Results indicated that on the FACES-IIII cohesion dimension, both parents and adolescents perceived their family relations as more disengaged and less connected than did normative families (p < .001). In contrast, only parent FACES-IIII adaptability scores were significantly more extreme than a normative sample (p < .01). Additionally, both parent and adolescent cohesion scores were significantly correlated with adolescent psyehopathology measures: DISC-C conduct disorder (p < .01), depression (p < .05), alcohol/marijuana (p < .01), and CBCL externalizing symptoms (p < .01). These relationships did not deviate from linearity. We gratefully acknowledge Eric C. Brown, Sue Greer, and Sharon P. Lardieri for assistance in data management of this project. Preparation of this article was supported by grant H133B90004-01 from the National Institute on Disability Rehabilitation Research and the National Institute of Mental Health.