Anterior temporal cortex and semantic memory: Reconciling findings from neuropsychology and functional imaging

Studies of semantic impairment arising from brain disease suggest that the anterior temporal lobes are critical for semantic abilities in humans; yet activation of these regions is rarely reported in functional imaging studies of healthy controls performing semantic tasks. Here, we combined neuropsychological and PE T functional imaging data to show that when healthy subjects identify concepts at a specific level, the regions activated correspond to the site of maximal atrophy in patients with relatively pure semantic impairment. The stimuli were color photographs of common animals or vehicles, and the task was category verification at specific (e.g., robin), intermediate (e.g., bird), or general (e.g., animal) levels. Specific, relative to general, categorization activated the antero-lateral temporal cortices bilaterally, despite matching of these experimental conditions for difficulty. Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information.     

Speech-specific auditory processing: where is it?

Are speech-specific processes localized in dedicated cortical regions or do they emerge from developmental plasticity in the connections among non-dedicated regions? Here we claim that all the brain regions activated by the processing of auditory speech can be re-classified according to whether they respond to non-verbal environmental sounds, pitch changes, unfamiliar melodies, or conceptual processes. We therefore argue that speech-specific processing emerges from differential demands on auditory and conceptual processes that are shared by speech and non-speech stimuli. This has implications for domain- vs. process-specific cognitive models, and for the relative importance of segregation and integration in functional anatomy.     

Understanding the Role of Neighborhood Context in the Long-Term Criminal Consequences of Child Maltreatment

This study investigated how neighborhood conditions influence the relationship between early child maltreatment and criminal behavior, using official data from a sample of maltreated children (N = 908) and matched controls (N = 667), as well as census data about respondents' neighborhoods. Using multilevel data that incorporated information about individuals, families, and neighborhoods, 2 hypotheses (direct influence and interaction effect) were examined using hierarchical generalized linear modeling (HGLM). The results indicated that neighborhood disadvantage and stability moderated the relationship between early child maltreatment and offending. Specifically, the effect of early child maltreatment on later juvenile and adult criminal behavior was strongest for those individuals from the most disadvantaged and most stable neighborhoods. These results suggest that studying the interaction between family functioning and neighborhood conditions provides a more comprehensive understanding of offending than does studying each factor separately.     

Cultural differences in affective forecasting: the role of focalism

The impact bias in affective forecasting-a tendency to overestimate the emotional consequences of future events-may not be a universal phenomenon. This prediction bias stems from a cognitive process known as focalism, whereby predictors focus attention narrowly on the upcoming target event. Three studies supported the hypothesis that East Asians, who tend to think more holistically than Westerners, would be less susceptible to focalism and, consequently, to the impact bias. In Studies 1 and 2, Euro-Canadians exhibited the impact bias for positive future events, whereas East Asians did not. A thought focus measure indicated that the cultural difference in prediction was mediated by the extent to which participants focused on the target event (i.e., focalism). In Study 3, a thought focus manipulation revealed that defocused Euro-Canadians and East Asians made equally moderate affective forecasts.     

Patterns of Coping Among Persons with HIV Infection: Configurations, Correlates, and Change

This study examines coping in response to HIV infection, using longitudinal data from a nationally representative sample (n = 2,864) of HIV-infected persons. We investigated configurations of coping responses, the correlates of configuration membership, the stability of coping configurations, and the relationship of coping to emotional well-being. Four coping configurations emerged from cluster analyses: relatively frequent use of blame-withdrawal coping, frequent use of distancing, frequent active-approach coping, and infrequent use of all three coping strategies (passive copers). Passive copers had few symptoms, high levels of physical functioning, and high emotional well-being; blame-withdrawal copers had the opposite pattern. Of those completing a second interview 1 year after baseline, 46% had the same coping configuration. Increases in the number of HIV-related symptoms raised the probability of blame-withdrawal coping at follow-up, whereas decreases raised the probability of passive coping. Infrequent use of coping responses at baseline was related to greater emotional well-being 1 year later. This result, in conjunction with the high levels of emotional well-being in the passive cluster, suggests that high levels of distress can induce blame-withdrawal coping whereas coping efforts are minimal when social support and emotional well-being are high. Results highlight issues in ascertaining the causal direction between coping and psychological outcomes, as well as in specifying the nature of stressful situations with which people are coping.     

Functional imaging of the semantic system: retrieval of sensory-experienced and verbally learned knowledge

This paper considers how functional neuro-imaging can be used to investigate the organization of the semantic system and the limitations associated with this technique. The majority of the functional imaging studies of the semantic system have looked for divisions by varying stimulus category. These studies have led to divergent results and no clear anatomical hypotheses have emerged to account for the dissociations seen in behavioral studies. Only a few functional imaging studies have used task as a variable to differentiate the neural correlates of semantic features more directly. We extend these findings by presenting a new study that contrasts tasks that differentially weight sensory (color and taste) and verbally learned (origin) semantic features. Irrespective of the type of semantic feature retrieved, a common semantic system was activated as demonstrated in many previous studies. In addition, the retrieval of verbally learned, but not sensory-experienced, features enhanced activation in medial and lateral posterior parietal areas. We attribute these "verbally learned" effects to differences in retrieval strategy and conclude that evidence for segregation of semantic features at an anatomical level remains weak. We believe that functional imaging has the potential to increase our understanding of the neuronal infrastructure that sustains semantic processing but progress may require multiple experiments until a consistent explanatory framework emerges.     

Murdoch's ontological argument

Anselm's ontological argument is an argument for the existence of God. This paper presents Iris Murdoch's ontological argument for the existence of the Good. It discusses her interpretation of Anselm's argument, her own distinctive appropriation of it, as well as some of the merits of her version of the argument. In doing so, it also shows how the argument integrates some key Murdochian ideas: morality's wide scope, the basicness of vision to morality, moral realism, and Platonism.     

Genetic Testing Considerations in Breast Cancer Patients

Genetic testing is now feasible for a growing number of cancers. Although the implications for unaffected relatives have been widely described, the impact of the tests on affected individuals are often not recognized. We present and discuss four cases that highlight some of the issues—for example, feelings of guilt and anxiety, intrafamilial conflict, and support needs—that may arise in testing affected individuals. We offer some suggestions to aid in the approach to such testing.     

Precocious conservation in context: The solution of quantity tasks by nonquantitative strategies

C. Sinha and B. Carabine's (1981, Journal of Child Language, 8, 109–129) claim of a U-shaped course to the development of quantitative knowledge with an early stage of conservation based on functional significance was tested in two experiments. Children at three age groups from 3 to 6 years were presented with the original procedure or control versions in which the display was slightly altered. Results showed that although Sinha and Carabine's result was replicable, their interpretation is unwarranted. Performance in the younger groups was best interpreted as the use of nonquantitative possession or position strategies.