Prospective Evaluation of Predictive DNA Testing for Huntington’s Disease in a Large German Center

We present a prospective study of counselees seeking predictive testing for Huntington’s disease at the Huntington Center North Rhine-Westphalia (Bochum, Germany) between 2010 and 2012. The aim was to observe the decision-making process of at-risk individuals and explore their experiences following the decision as well as the impacts of positive and negative mutation results. Data were collected using two standardized questionnaires as well as via a semi-standardized telephone interview one year after the initial counseling session. Seventy-two  individuals participated in at least one of the three phases of the survey, including 31 individuals in the telephone interview. Sociodemographic data were in accordance with previous reports. The process of predictive testing was generally perceived in a positive manner, with almost all interviewees reporting a balanced emotional state one year after initial counseling, regardless of the decision for or against the test. The most important reasons named in favor of or against testing were assembled as well as different aspects regarding the satisfaction with the reached decision. In line with and expanding previous observations on gender-related differences in decision-making, our results suggest that gender-related aspects should be more strongly taken into account in genetic counseling during the predictive testing and counseling processes.     

People avoid situations that enable them to deceive others

Information advantage enables people to benefit themselves by deceiving their counterparts. Using a modified ultimatum bargaining game with an exit option, we find that people are more likely to avoid settings enabling them to privately deceive their counterparts than settings which do not enable deception. This tendency is explained by people's reduced desire to become responsible for the other's outcomes when deception is possible. Results of three experiments show that people avoid entering a setting that enables deception by appearing fair while being unfair (Exp. 1–3). Experiment 2 showed that this tendency was reduced when interaction partners were displayed as competitive rather than cooperative. Experiment 3 showed a stronger tendency to avoid tempting situations that enable private deception than to approach situations in which one can privately benefit others. We conclude that when navigating through social space, people avoid situations enabling them to deceive others.     

Making up for lost opportunities: the protective role of downward social comparisons for coping with regrets across adulthood

Two longitudinal studies showed that if adults confront low opportunities to overcome regrets, downward social comparisons can exert self-protective functions across the adult life span, irrespective of age (Study 1 N = 104 young and older adults, Study 2 N = 51 older adults). Both studies found that downward relative to upward social comparisons were associated with improvements in participants' positive (but not negative) affect, if they perceived low as opposed to high opportunities to overcome regrets. Moreover, Study 2 showed that this beneficial effect on change in positive affect mediated the experience of fewer cold symptoms over time. Supplemental analyses further indicated that the mechanism linking social comparison processes and opportunities with positive (but not negative) affect was associated with the capacity for goal reengagement. In addition, these analyses showed that the obtained effects were largely unrelated to the severity of regret-related consequences and thus ruled out an alternative explanation of the findings.     

Nonassociative learning processes determine expression and extinction of conditioned fear in mice

Freezing to a tone following auditory fear conditioning is commonly considered as a measure of the strength of the tone-shock association. The decrease in freezing on repeated nonreinforced tone presentation following conditioning, in turn, is attributed to the formation of an inhibitory association between tone and shock that leads to a suppression of the expression of fear. This study challenges these concepts for auditory fear conditioning in mice. We show that acquisition of conditioned fear by a few tone-shock pairings is accompanied by a nonassociative sensitization process. As a consequence, the freezing response of conditioned mice seems to be determined by both associative and nonassociative memory components. Our data suggest that the intensity of freezing as a function of footshock intensity is primarily determined by the nonassociative component, whereas the associative component is more or less categorical. We next demonstrate that the decrease in freezing on repeated nonreinforced tone presentation following conditioning shows fundamental properties of habituation. Thus, it might be regarded as a habituation-like process, which abolishes the influence of sensitization on the freezing response to the tone without affecting the expression of the associative memory component. Taken together, this study merges the dual-process theory of habituation with the concept of classical fear conditioning and demonstrates that sensitization and habituation as two nonassociative learning processes may critically determine the expression of conditioned fear in mice.     

Adaptive self-regulation of unattainable goals: goal disengagement, goal reengagement, and subjective well-being

Three studies examined associations between goal disengagement, goal reengagement, and subjective well-being. In Study 1, 115 undergraduates reported on the extent to which they were able to abandon unattainable goals and reengage their efforts in alternative goals. Study 2 examined the importance of goal disengagement and goal reengagement in groups of young adults and older adults (N = 120). In Study 3, a sample of parents of children with cancer and parents of medically healthy children was examined (N = 45). The findings confirmed that goal disengagement and goal reengagement can be associated with ratings of high subjective well-being. In addition, the results showed that goal disengagement and goal reengagement can have interactive effects on subjective well-being. The importance of the findings for effective self-regulation and successful development are discussed.     

Perceptions and implications of received spousal care: evidence from the Caregiver Health Effects Study

The experiences of older care recipients have received far less theoretical and empirical attention than those of their family caregivers. In this study of 91 care recipients, the authors assessed perceptions of the amount, timing, and manner of spousal assistance; the amount of strain experienced from receiving care; and psychological well-being. Although female care recipients were more likely to report dissatisfaction with the manner in which assistance was provided, there were few gender differences in perceptions of care overall. In a stringent test of the hypothesis that perceived quality of spousal care affects recipient well-being, the authors found that poorer quality of care was related to increased depressive symptoms and a decreased sense of mastery 1 year later. These longitudinal effects were independent of the recipient's physical disability, marital quality, and care-receiving strain as well as the caregiver's well-being. These findings argue for a comprehensive assessment of the care-receiving experience that includes both care-recipient and caregiver perspectives.     

The influence of articulation,self‐monitoring ability,and sensitivity to others on creativity

Although it is often recommended to think aloud to solve problems and to become more creative, cognitive and social psychological research suggests thinking aloud may actually produce less creative ideas than thinking in silence. The results of two experiments indeed showed that thinking aloud hinders creativity—although people produced the same amount of new uses for an object, these were judged to be less original in the thinking aloud condition. Experiment 2 further showed that this effect was particularly pronounced for individuals with high sensitivity to what other's think of them and low ability to adapt to these expectations. From this, we conclude that the felt presence of an actual or implied audience when thinking aloud, reduces creative idea generation especially among those having difficulty adapting to others. Implications for creativity research, and for promoting creativity in applied settings such as organizational teams are discussed. Copyright © 2006 John Wiley & Sons, Ltd.     

Giving up on unattainable goals: benefits for health?

Three studies examined associations between goal disengagement and goal reengagement tendencies and indicators of physical health (e.g., health problems, cortisol rhythms, sleep efficiency). Based on research showing that goal adjustment tendencies are associated with subjective well-being, the authors predicted that people who are better able to disengage from unattainable goals and reengage with alternative goals also may experience better physical health. Across the three studies, the findings demonstrate that the ability to disengage from unattainable goals is associated with better self-reported health and more normative patterns of diurnal cortisol secretion. Goal reengagement, by contrast, was unrelated to indicators of physical health but buffered some of the adverse effects of difficulty with goal disengagement. The results also indicate that subjective well-being can mediate the associations between goal disengagement tendencies and physical health.