ALDH2 status and conduct disorder mediate the relationship between ethnicity and alcohol dependence in Chinese, Korean, and White American college students

This study examined aldehyde dehydrogense (ALDH2) gene status, alcohol dehydrogense (ADH2) gene status, conduct disorder, and alcohol dependence in Chinese, Korean, and White American college students. Chinese had a lower rate of alcohol dependence (5%) than Koreans (13%) and Whites (17%). Koreans had a higher rate of conduct disorder (15%) than Whites (9%) and Chinese (6%). The relationship of ethnicity to alcohol dependence was mediated by ALDH2 status and conduct disorder, although Chinese ethnicity remained significant. ADH2 status was not related to alcohol dependence with ALDH2 included, and no interactions were significant. Results suggest that different rates of risk (e.g., conduct disorder) and protective (e.g., ALDH2 status) factors partially account for ethnic differences in rates of alcohol dependence.     

Functional analysis and treatment of the bizarre speech of dually diagnosed adults

Nine behavior-analytic studies, each reporting data for a single participant, have shown that bizarre speech can be maintained by social reinforcement. In the current study, we controlled for a possible referral bias in this literature by including nonreferred participants with dual diagnoses. Functional analyses identified attention functions for 2 participants and nonsocial functions for the others. Noncontingent reinforcement decreased the bizarre speech of both participants who displayed attention-maintained bizarre speech.     

A genetic association with the development of alcohol and other substance use behavior in Asian Americans

Studies of Asian adults have found that alcohol use and alcohol dependence are related to variation in the aldehyde dehydrogenase (ALDH2) gene. To investigate the association of ALDH2 with the development of drug involvement, the authors analyzed retrospective information about the onset and regular use of alcohol and other substances as reported by 180 Asian American college students. Possession of an ALDH2*2 allele was not related to initiation of alcohol use or having ever been intoxicated, but individuals with ALDH2*2 alleles were less likely to be regular drinkers, were less likely to have engaged in a binge-drinking episode, reported a lower number of maximum drinks consumed in a 24-hr period, and were less likely to have used tobacco regularly than those without this genetic variant. These findings suggest that ALDH2 is associated with the development of not only alcohol-related behavior but other substance use behavior as well.     

Gender differences in salivary alpha-amylase and attentional bias towards negative facial expressions following acute stress induction

This study investigated gender differences in two key processes involved in anxiety, arousal and attentional bias towards threat. Arousal was assessed using salivary alpha-amylase (sAA), a biomarker of noradrenergic arousal and attention bias using a dot-probe task. Twenty-nine women and 27 men completed the dot-probe task and provided saliva samples before and after a stress induction [cold pressor stress (CPS) test]. Women displayed a significant increase in arousal (sAA) following the stressor compared to men, who displayed a significant reduction in arousal. Reaction time data revealed a significant avoidance of threat in women at baseline, but a significant change to an attention bias towards threat following the stressor. Men did not significantly respond to the stressor in terms of attentional bias. These findings suggest that women are more reactive to a stressor than men, and display an initial avoidance response to threat, but an attentional bias towards threat following stress.     

On the use of the term ‘frequency’ in applied behavior analysis

There exists a terminological problem in applied behavior analysis: the term frequency has been used as a synonym for both rate (the number of responses per time) and count (the number of responses). To guide decisions about the use and meaning of frequency, we surveyed the usage of frequency in contemporary behavior‐analytic journals and textbooks and found that the predominant usage of frequency was as count, not rate. Thus, we encourage behavior analysts to use frequency as a synonym for count.     

Idiosyncratic effects of noncontingent reinforcement on problematic speech

Noncontingent reinforcement (NCR) was used to treat the attention‐maintained problematic speech of an adult male diagnosed with moderate mental retardation. A series of functional assessments was conducted that included informant interviews and a brief experimental analysis. A multiple‐baseline design was then used to assess the effects of NCR across two different therapists. Although the target behavior was substantially decreased from baseline levels, the reduction was inversely related to the density of the NCR schedule. Within‐session analyses were then used to hypothesize putative behavior‐change mechanisms responsible for the reduction. The results are discussed in relation to the active components underlying the effects of NCR. Copyright © 1999 John Wiley & Sons, Ltd.     

On the role of stimulus preference assessment in the evaluation of contingent access to stimuli associated with stereotypy during behavioral acquisition

Previous authors have reported successful behavioral acquisition in children diagnosed with autism using contingent access to stereotypic responding as reinforcement. Other studies have demonstrated robust reinforcement effects when consequences were selected using stimulus preference assessments. We conducted two stimulus preference assessments with a six-year-old female diagnosed with autism. Her acquisition of a non-vocal imitation response was then evaluated during two reinforcement conditions: contingent access to (i) a stimulus associated with stereotypic object manipulation and (ii) a stimulus unassociated with such stereotypy. Both stimuli were identified from the stimulus preference assessments. Nearly identical response patterns were observed in both conditions; correct responses to verbal prompts greatly increased while correct responses to gestural and physical prompts decreased to near-zero levels. These preliminary findings are discussed in the context of improving stimulus selection in this area. © 1998 John Wiley & Sons, Ltd.     

Functional analysis of hair manipulation: a replication and extension

In a multi‐phase investigation, we assessed the problematic hair manipulation of a four‐year‐old male diagnosed with autism. In phase 1, a functional analysis of hair manipulation resulted in high levels of responding during a no‐interaction condition, while near‐zero levels were observed in other conditions. In phase 2, hair manipulation was reduced to near‐zero levels during a condition in which Billy wore gloves on his hands to attenuate digital‐tactile stimulation. In phase 3, a stimulus preference assessment indicated that object manipulation competed with hair manipulation, and that wearing gloves did not alter the amount of time that Billy manipulated preferred objects. The results are discussed in the context of interventions that achieve their effects via reinforcer substitutability or competition. Copyright © 2000 John Wiley & Sons, Ltd.