Impairment of spontaneous alternation performance by an NMDA antagonist: attenuation with non-NMDA treatments.

N-Methyl-D-aspartate (NMDA) receptor antagonists disrupt learning on a variety of tasks. Previous findings indicate that glucose, naloxone, and physostigmine ameliorate learning deficits produced by several treatments. The present experiment examines whether these agents also reverse the amnestic effects of NMDA receptor blockade. Mice were tested for spontaneous alternation performance in a Y-maze. The animals received either saline or the NMDA antagonist, NPC 12626 (35 mg/kg, IP), 50 min prior to testing and received an additional injection of saline, glucose, naloxone, or physostigmine 30 min prior to testing. NPC 12626 significantly decreased alternation scores. Glucose (250 mg/kg), physostigmine (0.01 mg/kg), and naloxone (1 mg/kg) reversed the effects of NPC 12626. Thus, impairments of learning after NMDA receptor blockade share with other amnestic conditions the susceptibility to attenuation by glucose, naloxone, and physostigmine.     

Decelerative cardiac responsiveness to acoustical stimulation in the near term fetus

Human fetal cardiac responses (36-39 weeks gestational age) to brief, repeated vocal stimuli (male or female voice uttering the same sentence), given at 90-95 dB SPL ex utero (around 20-30 dB less in utero) during a state of low fetal heart rate (FHR) variability, were examined using highly conservative statistical criteria taking into account each subject's prestimulus FHR variability. Subjects exposed to either of the two stimuli displayed significantly more decelerative heart rate (HR) changes compared to control subjects receiving no stimulation. The decelerative changes started during the first seconds following the onset of stimulation and reached their amplitude peak within 10 or 20 sec, depending on the subject. The directions—HR acceleration or deceleration—and the amplitude of the response depended on prestimulus HR variability only, not on prestimulus level. No major difference was found between the effects of the two voices. The data are compared to previous studies demonstrating fetal decelerative changes to acoustic stimuli of less than 105 dB SPL. The choice of an objective criterion to define an HR response and the possible orienting response nature of the decelerative change are discussed.     

Games teams play: A method for investigating team coordination and performance

Teams are playing an increasingly important role in the workplace. However, reviews of the team performance literature have suggested that there are serious deficiencies in our understanding of team processes and performance (e.g., Dyer, 1984). These difficulties may be attributable, in part, to the lack of laboratory methodologies to investigate team performance. This paper describes the use of low-fidelity simulations as a potentially useful paradigm for researching team coordination and performance. This paradigm is advantageous in that it offers relatively high levels of experimental control and task representation at a low cost.     

ACTH 4-9 analog can retard spatial alternation learning in brain damaged and normal rats

Thirty adult male hooded rats (Long-Evans strain) were assigned randomly to one of three lesion groups (n = 10) and prepared with medial frontal, posterior parietal, or sham neocortical injuries. Following a recovery interval of 10-12 days, access to water was limited to 30 min per day and the rats were shaped to traverse a T-maze for a reward of sweetened water. After a pretraining criterion was attained, osmotic minipumps (Alzet 2002) were installed subcutaneously. The minipumps delivered chronically for the next 14 to 15 days either 0 or 1.2 micrograms of ACTH 4-9 dissolved in bacteriostatic saline per day while the rats were trained on a reinforced spatial alternation task. Analysis of the number of errors made to a criterion of at least 80% correct alternations in two consecutive training sessions, or a ceiling of 62 errors (attained by two rats with parietal lesions), revealed that learning was impaired in the rats with parietal injuries. Contrary to our hypothesis, animals receiving ACTH 4-9 committed more errors than their counterparts receiving only saline.     

TEACHING SUPPORTED EMPLOYEES WITH SEVERE MENTAL RETARDATION TO SOLVE PROBLEMS

Two individuals with severe mental retardation, employed by a janitorial supply company, were taught to use self-instruction in combination with multiple exemplar training to solve work-related problems. Use of the combined strategy resulted in generalization of the effects of independent variables, as well as generalization to nontrained problems. Use of the strategy is discussed in terms of promoting independent performance among supported employees.     

Ethical considerations in the use of computers in psychological testing and assessment

Ethical considerations in the use of computers in psychological testing and assessment are discussed. Particular attention is given to existing ethics and standards that provide guidance to users of computerized test interpretation and report-writing programs. Issues covering professional accountability and confidentiality are also discussed as they relate to computer-assisted assessment. Areas of appropriate use of computers in testing and assessment are suggested, including test scoring, the analysis of scores, and generating remedial recommendations. Findings are summarized and several guidelines are suggested for users of computers in testing and assessment.     

Seeking urgent pediatric treatment: factors contributing to frequency, delay, and appropriateness

The present study explored the factors that contribute to mothers' decisions to seek urgent medical attention for their children when symptoms are not of a traumatic nature. One hundred mothers seeking treatment for their children at a prepaid clinic completed a questionnaire eliciting their expectations regarding the course of their children's problems, seriousness of the problems, perceived responsibility for the symptoms, and extent to which a variety of factors contributed to their decisions to seek treatment. Demographic data and information about each child's symptoms and medical history were also obtained. Four major "reasons for seeking treatment" factors were identified: family history of the presenting complaint, worry regarding the symptoms, situational variables, and the extent of the child's illness behavior. The appropriateness of the visit, delay in seeking treatment, and frequency of mothers' use of the pediatric clinic were predicted by the nature of the presenting symptoms (particularly the presence of fever), the ages of the mother and child, and two of the reasons for seeking treatment factors (i.e., family history and child's illness behavior). The present study suggests that mothers pay more attention to presenting symptoms and to the children's behavior than to psychosocial stressors in deciding to seek urgent care.     

An “outside-in” processing strategy in the perception of form

The discriminability of line segments in a number of different geometric forms was examined. The procedure used was to have one of the lines within a given form drawn thinner than the other lines. The location of the thin line varied randomly within the form, and subjects were required to detect its location. Three observations were made. First, outer line elements were discriminated more accurately than inner line elements. Second, the outer line advantage appeared to reflect an attentional strategy: By presenting inner and outer lines independently, and informing subjects in advance as to whether target lines would be in the inner or outer area of the form, the outer line advantage could be eliminated. Third, consonant with a global attentional strategy, and in opposition to any retinally tied, peripheral-to-central scanning process, an outer-line advantage was evident regardless of whether the fixation point was positioned within or outside the forms, or whether outer lines were more peripheral than inner lines.