The effect of alterations in consciousness on quality of life (QoL) in epilepsy: searching for evidence

The impact of epilepsy on quality of life (QoL) is well-documented. The ability of epileptic seizures to alter the conscious states of patients is also well established. Although there is much research on the QoL of people with epilepsy, few researchers have looked specifically at the effect of sudden, unanticipated alterations of consciousness on QoL. This lack of systematic studies of consciousness alterations and QoL in epilepsy limits our ability to shed light on this interrelation. In this article, with these limitations in mind, we focus on studies of newer AEDs. We review the evidence as to whether a significant reduction (typically more than 50%) in seizures that induce alterations of consciousness, as a result of switching to one of the newer AEDs, leads to improvements in QoL. We draw on this literature to speculate on the relationship between ictal consciousness alterations and poor QoL in epilepsy, to identify contributory and confounding factors and to highlight implications for future research. We suggest that an understanding of how factors associated with consciousness impairment affect QoL could help the treatment and management of these patients.     

��If This is What I��m ��Meant to be������: The Journeys of Students Participating in a Conversation Partner Scheme for People with Aphasia

The development of speech language therapy students into clinicians is an area of increasing interest as educators focus on how knowledge, skills and attitudes are taught and learnt within the profession. The personal journeys of students through experiences of service learning have potential to further our understanding of the impact of civic engagement on the student experience and their learning. This paper explores the journeys of first year speech and language therapy students through a Thematic Analysis of reflective letters written by students to themselves at the beginning and completion of a service learning module. Analysis demonstrates development of interpersonal and preclinical skills as well as an understanding of attitudes and values inherent in the social model of disability. The skills and attitudes developed by the students through participation in the Conversation Partner Scheme are consistent with social model principles that support therapists to fully address the long-term, real life needs of clients with aphasia (the acquired communication disorder that frequently follows stroke). The interface between the social model of disability and the role of service learning in nurturing the attitudes and values which underpin this model are explored.     

Temporal coordination between performing musicians

Many common behaviours require people to coordinate the timing of their actions with the timing of others' actions. We examined whether representations of musicians' actions are activated in coperformers with whom they must coordinate their actions in time and whether coperformers simulate each other's actions using their own motor systems during temporal coordination. Pianists performed right-hand melodies along with simple or complex left-hand accompaniments produced by themselves or by another pianist. Individual performers' preferred performance rates were measured in solo performance of the right-hand melody. The complexity of the left-hand accompaniment influenced the temporal grouping structure of the right-hand melody in the same way when it was performed by the self or by the duet partner, providing some support for the action corepresentation hypothesis. In contrast, accompaniment complexity had little influence on temporal coordination measures (asynchronies and cross-correlations between parts). Temporal coordination measures were influenced by a priori similarities between partners' preferred rates; partners who had similar preferred rates in solo performance were better synchronized and showed mutual adaptation to each other's timing during duet performances. These findings extend previous findings of action corepresentation and action simulation to a task that requires precise temporal coordination of independent yet simultaneous actions.     

Better elementary number processing in higher skill arithmetic problem solvers: evidence from the encoding step

This paper addresses the relationship between basic numerical processes and higher level numerical abilities in normal achieving adults. In the first experiment we inferred the elementary numerical abilities of university students from the time they needed to encode numerical information involved in complex additions and subtractions. We interpreted the shorter encoding times in good arithmetic problem solvers as revealing clearer or more accessible representations of numbers. The second experiment shows that these results cannot be due to the fact that lower skilled individuals experience more maths anxiety or put more cognitive efforts into calculations than do higher skilled individuals. Moreover, the third experiment involving non-numerical information supports the hypothesis that these interindividual differences are specific to number processing. The possible causal relationships between basic and higher level numerical abilities are discussed.     

Sensitivity to time interval changes in speech and tone conditions

The main goal of the present experiment was to verify whether sensitivity to time interval changes in speech is greater than sensitivity to time interval changes between tones. The 12-syllable sentences were delivered in French (the main language of the participants) or in a foreign language (Slovenian) that was totally unfamiliar to the participants. Two types of sub-sequences were induced within the series of stimuli (sub-sequences in sentences or in tone sequences). Discrimination, as revealed by the Weber fraction in each condition, was much better in the tone conditions than in the speech conditions. Nevertheless, discrimination was excellent in all conditions: Weber fractions below 2% with tones and around 4.5% in the speech conditions. Moreover, the study revealed that familiarity with a particular language does not affect performance and that inducing internal sub-sequences within tone conditions, as opposed to using a series of equal intervals, does not lead to better discrimination. The fact that discrimination is better with tones than with sentences indicates that the extensive training provided by speech does not lead to higher sensitivity to time interval variations than simple tones do. Instead, it seems to indicate that the different acoustical variations in speech reduce the capability to discriminate time interval variations.     

Interplay between acoustic/phonetic and semantic processes during spoken sentence comprehension: an ERP study

When listening to speech in everyday-life situations, our cognitive system must often cope with signal instabilities such as sudden breaks, mispronunciations, interfering noises or reverberations potentially causing disruptions at the acoustic/phonetic interface and preventing efficient lexical access and semantic integration. The physiological mechanisms allowing listeners to react instantaneously to such fast and unexpected perturbations in order to maintain intelligibility of the delivered message are still partly unknown. The present electroencephalography (EEG) study aimed at investigating the cortical responses to real-time detection of a sudden acoustic/phonetic change occurring in connected speech and how these mechanisms interfere with semantic integration. Participants listened to sentences in which final words could contain signal reversals along the temporal dimension (time-reversed speech) of varying durations and could have either a low- or high-cloze probability within sentence context. Results revealed that early detection of the acoustic/phonetic change elicited a fronto-central negativity shortly after the onset of the manipulation that matched the spatio-temporal features of the Mismatch Negativity (MMN) recorded in the same participants during an oddball paradigm. Time reversal also affected late event-related potentials (ERPs) reflecting semantic expectancies (N400) differently when words were predictable or not from the sentence context. These findings are discussed in the context of brain signatures to transient acoustic/phonetic variations in speech. They contribute to a better understanding of natural speech comprehension as they show that acoustic/phonetic information and semantic knowledge strongly interact under adverse conditions.     

Depressive rumination in an analysand after a traumatic treatment

The author attempts to understand the underpinnings of a ruminative depression that occurred in a patient after a troubled first analysis. Negative therapeutic reaction is often assumed to be the result of a patient's unconscious guilt or masochism and thus an intrapsychic phenomenon, but the author asserts that iatrogenic phenomena in the form of persistent misunderstandings and enactments that remain unanalyzed contribute to a destructive treatment experience. The analysand may relive the failed treatment again and again in his or her mind in an attempt to resolve it. The author asserts that a traumatic treatment experience can foster depressive rumination.     

Percentile Norms and Accompanying Interval Estimates from an Australian General Adult Population Sample for Self‐Report Mood Scales (BAI,BDI, CRSD,CES‐D,DASS, DASS‐21, STAI‐X,STAI‐Y,SRDS, and SRAS)

Despite their widespread use, many self‐report mood scales have very limited normative data. To rectify this, Crawford et al. have recently provided percentile norms for a series of self‐report scales. The present study aimed to extend the work of Crawford et al. by providing percentile norms for additional mood scales based on samples drawn from the general Australian adult population. Participants completed a series of self‐report mood scales. The resultant normative data were incorporated into a computer programme that provides point and interval estimates of the percentile ranks corresponding to raw scores for each of the scales. The programme can be used to obtain point and interval estimates of the percentile ranks of an individual's raw scores on the Beck Anxiety Inventory, the Beck Depression Inventory, the Carroll Rating Scale for Depression, the Centre for Epidemiological Studies Rating Scale for Depression, the Depression, Anxiety, and Stress Scales (DASS), the short‐form version of the DASS (DASS‐21), the Self‐rating Scale for Anxiety, the Self‐rating Scale for Depression, the State–Trait Anxiety Inventory (STAI), form X, and the STAI, form Y, based on normative sample sizes ranging from 497 to 769. The interval estimates can be obtained using either classical or Bayesian methods as preferred. The programme (which can be downloaded at http://www.abdn.ac.uk/~psy086/dept/MoodScore_Aus.htm ) provides a convenient and reliable means of obtaining the percentile ranks of individuals' raw scores on self‐report mood scales.     

The development of abstract syntax: Evidence from structural priming and the lexical boost

Structural priming paradigms have been influential in shaping theories of adult sentence processing and theories of syntactic development. However, until recently there have been few attempts to provide an integrated account that explains both adult and developmental data. The aim of the present paper was to begin the process of integration by taking a developmental approach to structural priming. Using a dialog comprehension-to-production paradigm, we primed participants (3–4 year olds, 5–6 year olds and adults) with double object datives (Wendy gave Bob a dog) and prepositional datives (Wendy gave a dog to Bob). Half the participants heard the same verb in prime and target (e.g. gave–gave) and half heard a different verb (e.g. sent–gave). The results revealed substantial differences in the magnitude of priming across development. First, there was a small but significant abstract structural priming effect across all age groups, but this effect was larger in younger children than in older children and adults. Second, adding verb overlap between prime and target prompted a large, significant increase in the priming effect in adults (a lexical boost), a small, marginally significant increase in the older children and no increase in the youngest children. The results support the idea that abstract syntactic knowledge can develop independently of verb-specific frames. They also support the idea that different mechanisms may be needed to explain abstract structural priming and lexical priming, as predicted by the implicit learning account (Bock, K., & Griffin, Z. M. (2000). The persistence of structural priming: Transient activation or implicit learning? Journal of Experimental Psychology – General, 129(2), 177–192). Finally, the results illustrate the value of an integrative developmental approach to both theories of adult sentence processing and theories of syntax acquisition.     

Hangover sensitivity after controlled alcohol administration as predictor of post-college drinking

Predicting continued problematic levels of drinking after the early 20's could help with early identification of persons at risk. This study investigated whether hangover insensitivity could predict postcollege drinking and problems beyond the variance due to drinking patterns. In a preliminary study, 134 college seniors from a laboratory study of hangover (Time 1) were contacted and assessed 1-4 years (M = 2.3) later (Time 2). Hangover severity was studied after controlled alcohol administration to a specific dose while controlling sleep and environmental influences. Hangover severity at Time 1 was used to predict Time 2 drinking volume and problems while controlling for relevant demographics and Time 1 drinking volume. Hangover insensitivity at Time 1 tended to predict a clinical level of alcohol problems with a large statistical effect size. Hangover sensitivity also correlated positively with sensitivity to alcohol intoxication. Hangover severity did not predict future drinking volume. Hangover insensitivity correlates with insensitivity to intoxication and might predict more serious alcohol problems in the future, suggesting that a future larger study is warranted. Hangover insensitivity could result from physiological factors underlying low sensitivity to alcohol or risk for alcoholism.