On the requirement of nitric oxide signaling in the amygdala for consolidation of inhibitory avoidance memory

Evidence suggests that the NO/sGC/PKG pathway plays a key role in memory processing but the actual participation of this signaling cascade in the amygdala during memory consolidation remains unknown. Here, we show that when infused in the amygdala immediately after inhibitory avoidance training, but not later, the NO synthase inhibitor L-NNA hindered long-term memory retention without affecting locomotion, exploratory behavior, anxiety state or retrieval of the avoidance response. The amnesic effect of L-NNA was not state-dependent and was mimicked by the soluble guanylyl cyclase inhibitor LY83583 and the PKG inhibitor KT-5823. On the contrary, post-training intra-amygdala infusion of the NOS substrate L-Arg, the NO-releasing compound SNAP or the non-hydrolysable analog of cGMP 8Br-cGMP increased memory retention in a dose-dependent manner. Co-infusion of 8Br-cGMP reversed the amnesic effect of L-NNA and LY83583 but not that of KT-5823. Our data indicate that the NO-induced activation of PKG in the amygdala is a necessary step for consolidation of inhibitory avoidance memory.     

The relationship between search efficiency and crowding

The role of target salience in crowding has remained controversial largely because salience usually escapes objective measurement. Here we address this problem using search efficiency as a measure of target salience. In separate experiments observers determined whether parafoveal arrays of vertical Gabor patterns contained targets having a unique colour, a unique direction of motion, and a unique temporal frequency. We analysed search efficiency in the conventional manner using reaction-time gradients (in seconds per item). We also considered accuracy gradients (in percent-correct per item). Crowding is typically quantified by comparing the acuity for a target within an array to the acuity for a target presented alone. We measured orientation acuity for determining whether a slightly tilted target was clockwise or anticlockwise of vertical. Targets with a unique colour or direction of motion were found to pop out, ie (with one exception) reaction-time and accuracy gradients were insignificantly different from zero. Acuity for these targets was significantly greater than acuity for targets whose neighbours had the same colour and direction of motion. Manipulation of temporal frequency produced a wide range of search efficiencies. For three of four observers we found a linear relationship between acuity and the accuracy gradient, shallow gradients being associated with high acuity. In general, we find that crowding is weakened when observers can find a parafoveally presented target quickly and accurately.     

Psychological Follow-up of Presymptomatic Genetic Testing for Spinocerebellar Ataxia Type 2 (SCA2) in Cuba

Presymptomatic testing for spinocerebellar ataxia type 2 (SCA2) in Cuba started five years ago. We have now investigated the psychological impact of test results on 150 individuals at 50% risk for SCA2. In a prospective study, psychological instruments were used to evaluate depression, anxiety and family functioning (1) before testing and (2) one year after disclosure of the test result. One year after, anxiety and depression levels decreased both in carriers and non-carriers, but anxiety decreased significantly more in carriers. Pathological levels of anxiety were seen mostly in members of dysfunctional families, but decreased more in them than in other consultands. Presymptomatic testing thus seems to have been especially beneficial for these testees, possibly due to a greater gain from the psychosocial support received. It would be pertinent to evaluate now the impact of other psychosocial variables and perform longer-term longitudinal studies.     

Ten-year-old girls' and boys' body composition and peer victimization experiences: prospective associations with body satisfaction

This study examined prospective associations between 10-year-olds’ weight and height, their perception of shape and stature, frequent experiences of peer victimization, and different aspects of body esteem at age 13. Participants were 474 girls and 400 boys participating in a two-wave longitudinal questionnaire study. Main results were that whereas actually being heavier built at age 10 was associated with girls’ increments in body dissatisfaction, the mere perception of being too heavy was associated with boys’ poorer body satisfaction. Also, boys who believed that they were too short were more dissatisfied at follow-up. Whereas frequent peer victimization had long-term associations with girls’ weight-esteem, teasing targeted towards appearance was associated with boys’ more negative beliefs about what others think about their appearance. Finally, participants had become significantly more dissatisfied at age 13, suggesting that this is a time in life when both girls and boys risk becoming increasingly critical towards their appearance.     

Dieting behaviors, body shape perceptions, and body satisfaction: cross-cultural differences in Argentinean and Swedish 13-year-olds

This exploratory study represents a cross-cultural effort to examine differences in dieting practices and weight loss attempts, perceived body shape, and body satisfaction between young Argentinean and Swedish adolescents. The study group consisted of 358 Argentinean (193 girls, 165 boys) and 874 Swedish (474 girls, 400 boys) 13-year-olds. A main finding was that Argentinean and Swedish adolescents did not differ on body satisfaction, although girls in both countries displayed greater body dissatisfaction than did boys. Dieting and weight loss attempts were more prevalent among the Argentinean adolescents, especially among girls, and did not appear to depend on overweight or perception of body shape. The samples also differed in their perceptions of body shape and the effect those perceptions had on their body satisfaction, with Swedish adolescents suffering more from negative body shape perceptions.     

Pre-entry Characteristics,Perceived Social Support,Adjustment and Academic Achievement in First-Year Spanish University Students: A Path Model

Transition to university is a multifactorial process to which scarce consideration has been given in Spain, despite this being one of the countries with the highest rates of academic failure and attrition within the European Union. The present study proposes an empirical model for predicting Spanish students' academic achievement at university by considering pre-entry characteristics, perceived social support and adaptation to university, in a sample of 300 traditional first-year university students. The findings of the path analysis showed that pre-university achievement and academic and personal–emotional adjustment were direct predictors of academic achievement. Furthermore, gender, parents' education and family support were indirect predictors of academic achievement, mediated by pre-university grades and adjustment to university. The current findings supporting evidence that academic achievement in first-year Spanish students is the cumulative effect of pre-entry characteristics and process variables, key factors that should be taken into account in designing intervention strategies involving families and that establish stronger links between research findings and university policies.     

Association between obesity and suicide in woman,but not in man: a population-based study of young adults

The relationship between obesity and suicide risk is still unclear with controversial research results. The aim of this study is to investigate the relationship between obesity and suicide risk for men and women in a population-based study of young adults. This is a cross-sectional population-based study that identified young adults between 18 and 35 years of age. Suicide risk was investigated through the structured clinical interview Mini. Weight and height were assessed, and participants were classified as normal-weight body mass index (BMI < 30) or obese (BMI > 30). The prevalence of obesity was of 19.9% of the total sample (n = 1953). Obesity was more prevalent among women and participants between 27 and 35 years of age. Suicide risk was present in 13.0% of the sample and more prevalent among women. In our study we found an association between obesity and suicide risk for women, but not for men. Obesity was associated with a higher prevalence of suicide risk in women. Given the strength of the relationship between BMI and suicide, identifying the mechanisms associated with obesity, especially for women, can lead to new insights into the prevention of suicide risk     

Happiness and health behaviours among university students from 24 low,middle and high income countries

The aim of this study was to examine health behaviours and happiness and associated factors in low, middle and high income countries. In a cross-sectional survey, 17 508 undergraduate university students (mean age 20.9, SD = 2. 8) from 25 universities in 24 countries across Asia, Africa and the Americas self-completed anonymous questionnaires. Results indicate that the overall happiness mean score among university students across 24 countries was 13.7 (range 4–20). Generally, the study found that university students from countries of the Caribbean, South America and sub-Saharan Africa had greater happiness scores than students from countries in North Africa and Asia. In multivariate linear regression analysis, better subjective socio-economic status, coming from an higher income country, higher social support, higher intrinsic religiosity, higher personal mastery, positive health behaviours (regular breakfast, adequate physical activity, habitual seatbelt use, regular dental check-ups, not having had an injury, not drinking and driving) and negative health behaviours (not having three or more servings of vegetables and eating red meat daily) were correlated with happiness. Improvement to the happiness of university students should consider regional differences in socio-economic environment.     

Does the nature of the experience influence suggestibility? A study of children's event memory

Two experiments examined the effects of event modality on children's memory and suggestibility. In Experiment 1, 3- and 5-year-old children directly participated in, observed, or listened to a narrative about an event. In an interview immediately after the event, free recall was followed by misleading or leading questions and, in turn, test recall questions. One week later children were reinterviewed. In Experiment 2, 4-year-old children either participated in or listened to a story about an event, either a single time or to a criterion level of learning. Misleading questions were presented either immediately or 1 week after learning, followed by test recall questions. Five-year-old children were more accurate than 3-year-olds and those participating were more accurate than those either observing or listening to a narrative. However, method of assessment, level of event learning, delay to testing, and variables relating to the misled items also influenced the magnitude of misinformation effects.     

Parent-Child Interactions Among Low-Income Mexican American Parents and Preschoolers: Do Clinic-Referred Families Differ From Nonreferred Families?

This study compared low-income Mexican American parents of young children referred for behavior problems to their nonreferred counterparts on an observational measure of parent-child interactions. Referred Mexican American parents demonstrated more negative behaviors than their nonreferred counterparts in both nondirective and highly directive situations. However, no differences were found at moderate levels of directiveness. The most and least directive situations in the Dyadic Parent-Child Interaction Coding System best differentiated referred from nonreferred Mexican American families, and families differed more in their negative behaviors than positive behaviors. Many of the parenting behaviors that have been found to differ between referred and nonreferred Caucasian families were also observed to differ between their Mexican American counterparts.