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41.
Genetic studies of stuttering in a founder population 总被引:2,自引:0,他引:2
Wittke-Thompson JK Ambrose N Yairi E Roe C Cook EH Ober C Cox NJ 《Journal of Fluency Disorders》2007,32(1):33-50
Genome-wide linkage and association analyses were conducted to identify genetic determinants of stuttering in a founder population in which 48 individuals affected with stuttering are connected in a single 232-person genealogy. A novel approach was devised to account for all necessary relationships to enable multipoint linkage analysis. Regions with nominal evidence for linkage were found on chromosomes 3 (P=0.013, 208.8 centiMorgans (cM)), 13 (P=0.012, 52.6 cM), and 15 (P=0.02, 100 cM). Regions with nominal evidence for association with stuttering that overlapped with a linkage signal are located on chromosomes 3 (P=0.0047, 195 cM), 9 (P=0.0067, 46.5 cM), and 13 (P=0.0055, 52.6 cM). We also conducted the first meta-analysis for stuttering using results from linkage studies in the Hutterites and The Illinois International Genetics of Stuttering Project and identified regions with nominal evidence for linkage on chromosomes 2 (P=0.013, 180-195 cM) and 5 (P=0.0051, 105-120 cM; P=0.015, 120-135 cM). None of the linkage signals detected in the Hutterite sample alone, or in the meta-analysis, meet genome-wide criteria for significance, although some of the stronger signals overlap linkage mapping signals previously reported for other speech and language disorders. EDUCATIONAL OBJECTIVES: After reading this article, the reader will be able to: (1) summarize information about the background of common disorders and methodology of genetic studies; (2) evaluate the role of genetics in stuttering; (3) discuss the value of using founder populations in genetic studies; (4) articulate the importance of combining several studies in a meta-analysis; (5) discuss the overlap of genetic signals identified in stuttering with other speech and language disorders. 相似文献
42.
The authors describe the development of the Religious Occupations and Stress Questionnaire (ROS), which attempts to fill the need for an appropriate measure of the stress experienced by individuals in religious occupations. The ROS has 4 stress‐related subscales (General Stress. Occupational Stress, Identity/Image Stress, and Gender Issues Stress) and a Coping subscale. Results of reliability and validity studies of the ROS with male and female Protestants, Catholics, and Jews who were in religious occupations indicated high internal consistency, test‐retest reliability, and construct validity. 相似文献
43.
Klara Kovarski Florent Caetta Martial Mermillod Carole Peyrin Céline Perez Lionel Granjon Richard Delorme Ariane Cartigny Tiziana Zalla Sylvie Chokron 《Journal of Neuropsychology》2021,15(2):235-252
Autism spectrum disorder (ASD) is characterized by difficulties in the social domain, but also by hyper- and hypo-reactivity. Atypical visual behaviours and processing have often been observed. Nevertheless, several similar signs are also identified in other clinical conditions including cerebral visual impairments (CVI). In the present study, we investigated emotional face categorization in groups of children with ASD and CVI by comparing each group to typically developing individuals (TD) in two tasks. Stimuli were either non-filtered or filtered by low- and high-spatial frequencies (LSF and HSF). All participants completed the autism spectrum quotient score (AQ) and a complete neurovisual evaluation. The results show that while both clinical groups presented difficulties in the emotional face recognition tasks and atypical processing of filtered stimuli, they did not differ from one another. Additionally, autistic traits were observed in the CVI group and symmetrically, some visual disturbances were present in the ASD group as measured via the AQ score and a neurovisual evaluation, respectively. The present study suggests the relevance of comparing ASD to CVI by showing that emotional face categorization difficulties should not be solely considered as autism-specific but merit investigation for potential dysfunction of the visual processing neural network. These results are of interest in both clinical and research perspectives, indicating that systematic visual examination is warranted for individuals with ASD. 相似文献
44.
The experiment examines status and gender role explanations of the tendency for women to conform more than men in group pressure settings. Subjects believed they were assigned to groups containing two males and two females in addition to themselves and received these other group members' opinions, which were represented as deviating from the opinions that subjects had given earlier. Subjects then gave their opinions with the other group members either having or not having surveillance over these opinions. In addition, subjects were required to form impressions of each other's likability or expertise. The findings indicate that subjects' sex and age affected the extent of their conformity. Among older (19 years and older) subjects, females conformed more with surveillance than without it, whereas surveillance did not affect males' conformity. Among younger (under 19 years) subjects, surveillance had no effects. Analysis of sex differences revealed that older females were significantly more conforming than older males when under surveillance as well as when subjects formed impressions of one another's likability. Among younger subjects, there were no sex differences. These findings are discussed in terms of the theories that (a) both sex and age function as status characteristics and (b) gender roles determine conformity. 相似文献
45.
46.
Dr. Hal G. Gueutal Joan Luciano Carole A. Michaels 《Journal of business and psychology》1995,10(2):155-167
Archival data were collected to examine bias effects in performance evaluation related to employee pregnancy. Prior survey research has suggested that many supervisors and co-workers hold negative views of pregnant employees. Performance appraisal ratings were collected before, during, and after pregnancy for employees taking maternity leave over a four year time frame. In addition, data was also collected from randomly selected control subjects, which were matched on job title and observation period. Contrary to expectations, performance appraisal ratings were found to increase during pregnancy when compared to before ratings and control group ratings. Potential explanations as well as suggestions for further research are discussed. 相似文献
47.
48.
Jack R Rayman Carole B Bernard John L Holland David C Barnett 《Journal of Vocational Behavior》1983,23(3):346-355
The effects of a career course taught by 11 instructors (two sections each) for college students, who were undecided about a major field or career, were evaluated in a pre-post design using the Vocational Identity, Occupational Information, and Barrier scales of the My Vocational Situation (J. A. Holland, D. C. Daiger, & P. G. Power, Palo Alto, Calif.: Consulting Psychologists Press, 1980). Large main effects were observed for the Identity and Occupational Information scales, but not for the Barriers scale. No interactions by instructor or student characteristics were found by using a simple ANOVA procedure or by using a split plot factorial design. The implications for new research and career instructors were discussed. 相似文献
49.
DOMINANCE AND INEQUALITY IN X-RATED VIDEOCASSETTES 总被引:2,自引:0,他引:2
Gloria Cowan Carole Lee Daniella Levy Debra Snyder 《Psychology of women quarterly》1988,12(3):299-311
Feminists have been concerned about the debasement of women in sexually explicit material. The purpose of this study was to determine the extent of domination and sexual inequality in x-rated videocassettes through a content analysis of 45 widely available x-rated videocassettes. The sample was randomly drawn from a list of 121 adult movie titles widely available in family videocassette rental stores in southern California. Over half of the explicitly sexual scenes were coded as predominantly concerned with domination or exploitation. Most of the domination and exploitation was directed by men toward women. Specific indicators of domination and sexual inequality, including physical violence, occurred frequently. The growth of the videocassette rental industry and the popularity of x-rated films, coupled with the messages these films convey, is a cause for concern. 相似文献
50.
In order to investigate the relative strengths of status and sex-typing of occupations on evaluations of job outcomes, this study varied sex of subject, sex of stimulus person, status of occupation, sex-typing of occupation, and job outcome in a three-between, two-within factorial design. Contrary to previous research, subjects' beliefs about stimulus persons' affective reactions to job outcomes were not consistent with rigid sex-typing of jobs. Instead, the data suggest that crossing the sex-typing barrier in occupations is receiving growing acceptance, and that subjects are aware of sex segregation and discrimination in the labor force. Other data suggest that subjects' beliefs about job outcomes are influenced by belief in a just world.The authors wish to thank Walter G. Stephan for commenting on an earlier version of this article. 相似文献