Representation and working memory in early arithmetic

Working memory has been implicated in the early acquisition of arithmetic skill, but the relations among different components of working memory, performance on different types of arithmetic problems, and development have not been explored. Preschool and Grade 1 children completed measures of phonological, visual-spatial, and central executive working memory, as well as nonverbal and verbal arithmetic problems, some of which included irrelevant information. For preschool children, accuracy was higher on nonverbal problems than on verbal problems, and the best and only unique predictor of performance on the standard nonverbal problems was visual-spatial working memory. This finding is consistent with the view that most preschoolers use a mental model for arithmetic that requires visual-spatial working memory. For Grade 1 children, performance was equivalent on nonverbal and verbal problems, and phonological working memory was the best predictor of performance on standard verbal problems. For both age groups, problems with added irrelevant information were substantially more difficult than standard problems, and in some cases measures of the central executive predicted performance. Assessing performance on different components of working memory in conjunction with different types of arithmetic problems provided new insights into the developing relations between working memory and how children do arithmetic.     

Spatial learning in rats is impaired by microinfusions of protein kinase C-gamma antisense oligodeoxynucleotide within the nucleus accumbens

The nucleus accumbens (NAcc) has been shown to play a role in motor and spatial learning. Protein kinase C (PKC) has been implicated in the mechanisms of initiation and maintenance of long-term potentiation that is thought to be involved in the storage of long-term memory. In the present study, the importance of de novo synthesis of PKC-gamma within the NAcc in the acquisition and retention of spatial discrimination learning was assessed using an antisense knockdown approach. Separate groups of Long-Evans rats were exposed to acute microinfusions (6microg/microl) of PKC-gamma antisense oligodeoxynucleotide (AS-ODN), control oligodeoxynucleotide (C-ODN) or vehicle into the NAcc at 24 and 3h before each training session. Behavioral findings showed that the blockade of NAcc-PKC-gamma translation caused impairments in the early phase of learning and retention of spatial information. Biochemical experiments showed that PKC-gamma expression was reduced and Ca(2+)/phospholipid-dependent protein kinase C (PKC) activity was blocked significantly in the AS-ODN-treated rats in comparison with control rats. The present findings suggest that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning. Also, retention test results suggest that NAcc-PKC-gamma may be working as an intermediate factor involved in the onset of molecular mechanisms necessary for spatial memory consolidation within the NAcc.     

A facilitative role for corticosterone in the acquisition of a spatial task under moderate stress

Emotionally charged experiences alter memory storage via the activation of hormonal systems. Previously, we have shown that compared with rats trained for a massed spatial learning task in the water maze in warm water (25°C), animals that were trained in cold water (19°C) performed better and showed higher levels of the stress hormone corticosterone. Here, we examined whether manipulating the levels of corticosterone can determine the strength of spatial information acquisition and retention. Rats were injected with metyrapone (25, 50, and 75 mg/kg, i.p.) or with corticosterone (10 and 25 mg/kg, i.p.) and trained in a massed spatial task in either cold (19°C) or warm (25°C) water. We found that whereas animals injected with vehicle performed well in the spatial task in cold water (moderate stress), rats injected with the intermediate metyrapone dose showed impairment in performance. Moreover, whereas animals injected with vehicle on average did not perform well in warm water (mild stress), rats injected with the lower corticosterone dose showed improvement in performance in warm water. These two mirror experiments of corticosterone blockade and enhancement strongly suggest that corticosterone is instrumental in the acquisition and retention of the spatial learning task.     

Effects of suppressing neutral and obsession-like thoughts in normal subjects: beyond frequency

Recent cognitive-behavioral theories on obsessive-compulsive disorder (OCD) show that deliberate attempts to suppress intrusive and undesirable thoughts lie at the genesis of clinical obsessions. In this paper the results of an experimental study on the suppression of neutral and obsession-like thoughts in normal subjects are presented. Eighty-seven university students performed in three experimental periods: (1) base-line monitoring, (2) experimental instruction, and (3) monitoring. For each of these periods, the frequency of the occurrence of a "white bear" thought or a personally relevant intrusive thought was registered. Half of the subjects received instructions to suppress the target-thought in period 2, and the other half were instructed to only monitor the target-thought in each of the experimental periods. Several measures were also obtained before and after the experiment: annoyance caused by the intrusion, suppression effort, subjective success, and evaluative appraisals of the target-thought. The results showed neither immediate nor delayed frequency increases of the target thought. However, evidence was found that deliberate thought suppression efforts, regardless of their content, had greater negative consequences than did non suppression. These results are discussed in relation to the recent cognitive proposals about OCD.     

Directed forgetting of related words: evidence for the inefficient inhibition hypothesis

Fifth-grade children and college students were asked to remember some words and to forget others in an item-cued-directed-forgetting task. Taxonomically related pairs of words and control pairs that were unrelated in meaning were used as stimuli. Children found it more difficult than did adults to ignore forget-cued words that followed associatively related words that were remember-cued. The results provide support for D. F. Bjorklund and K. K. Harnishfeger's (1990) inefficient inhibition hypothesis (i.e., that the efficiency of inhibitory mechanisms improves as children develop). The results also suggest that the inhibition is occurring primarily in the early stages of processing.     

The time course of attentional focusing in dyslexic and normally reading children

A cue size procedure was used to evaluate the time course of visuo-spatial attention in dyslexic and normally reading children. When a stimulus target is presented inside a large cue vs a small cue the identification time is slower. In the present study two cue-target delays (100 and 500 ms) were used. Results showed a slower time course of attentional focusing in dyslexics vs normal readers. Indeed, dyslexics exhibited no cue size effect at a shorter cue-target delay (100 ms), while it was present at a longer cue-target delay (500 ms). In contrast, a cue size effect was found at both cue-target delays in normally reading children. These results further support the hypothesis of sluggish automatic focusing of visual attention in dyslexics. This impairment could be a consequence of a general magnocellular deficit demonstrated previously in dyslexics.     

A behavioural experiment in virtual reality to verify the role of action function in space coding

Neurophysiological data indicate that the reachable peripersonal space and the unreachable extrapersonal space are represented in segregated parietofrontal circuits and that when the unreachable space becomes reachable because of tool use, it is automatically coded by the network selective for peripersonal space. Here we directly tested the role of action's consequences in space coding. Thirty-eight participants bisected lines at either a reachable distance (60 cm) or unreachable distance (120 cm) using either a laser pointer or laser cutter. The laser cutter but not the laser pointer had an action consequence; the line broke into two pieces. The results showed that distance moderated the effect of action. At an unreachable distance, the mean bisection point was closer to the centre when participants used the laser cutter compared to when they used the laser pointer. There were no differences at a reachable distance (60 cm). This result suggests that the space in which the individual may determine a physical consequence is categorized as peripersonal space, independently from its actual distance from the individual's body.     

Is the go/no-go lexical decision task preferable to the yes/no task with developing readers?

The lexical decision task is probably the most common laboratory visual word identification task together with the naming task. In the usual setup, participants need to press the “yes” button when the stimulus is a word and the “no” button when the stimulus is not a word. A number of studies have employed this task with developing readers; however, error rates and/or response times tend to be quite high. One way to make the task easier for young readers is by employing a go/no-go procedure: “If word, press ‘yes’; if not, refrain from responding.” Here we conducted a lexical decision experiment that systematically compared the yes/no and go/no-go variants of the lexical decision task with developing readers (second- and fourth-grade children). Results showed that (a) error rates for words and nonwords were much lower in the go/no-go task than in the yes/no task, (b) lexical decision times were substantially faster in the go/no-go task, and (c) there was less variability in the latency data of the go/no-go task for high-frequency words. Thus, the go/no-go lexical decision task is preferable to the “standard” yes/no task when conducting experiments with developing readers.     

Relationships between early behavioural characteristics and temperament at 6 years

The aim of this study was to analyze the extent to which the relations and the stability of the neonatal behaviour and the infant behaviour at both 4 and 12 months could be used to predict the infant temperament at 6 years. Seventy-two full-term, normal-weight, healthy children were followed from 3 days postpartum to 6 years. Neonatal behaviour at 3 and 30 days was assessed using the Neonatal Behaviour Assessment Scale (NBAS), behaviour at 4 and 12 months was assessed using the Infant Behaviour Record (IBR) from the Bayley Scales for Infant Development (BSID) and temperament at 6 years was assessed using the Dimensions of Temperament Survey-Revised (DOTS-R). Negative and positive affectivity and attention were the factors extracted from the behaviours of the IBR. Our results showed a low/moderate correlation between neonatal behaviour on the one hand and behaviour at 4 and 12 months and temperament at 6 years on the other hand. The motor performance, orientation and ANS stability of the neonate at 3 and 30 days were predictors of positive and negative affectivity at 4 months. State regulation and ANS stability at 3 days were predictors of negative affectivity and attention respectively at 12 months. Negative affectivity at 12 months and endurance at 30 days were predictors of general activity and persistence/attention at 6 years. Also, an inverse relation was found between state regulation at 30 days and general activity at 6 years, and a positive relation was found between attention at 4 months and persistence/attention at 6 years. We conclude that neonatal behaviour and behaviour in the first year of life are good predictors of temperament at 6 years and that early negative affectivity has an important role on infant temperament development.     

Balancing the ledger: An application of Nagy's theories to the study of continuity and change among generations

This study uses an interpretive interview method to examine the micro-processes of generational continuity and change among a group of social activists. Boszormenyi-Nagy's theory of responsibility between generations, alternative models outside the family, and choice are used to explain the instances of change. Implications for research and practice are addressed.