Enhanced inhibitory avoidance learning prevents the long-term memory-impairing effects of cycloheximide,a protein synthesis inhibitor

Interference with activity of numerous cerebral structures produces memory deficiencies; in many instances, however, when animals are over-trained such interference becomes innocuous. Systemic administration of protein synthesis inhibitors impairs long-term retention; this effect has been interpreted to mean that protein synthesis is required for memory consolidation, though little is known about the effect of protein synthesis inhibitors on memory of enhanced learning in the rat. To further analyze the protective effect of enhanced learning against amnesic treatments, groups of Wistar rats were trained in a one-trial step-through inhibitory avoidance task, using different intensities of foot-shock during training. Cycloheximide (CXM; 2.8 mg/kg), an inhibitor of protein synthesis, was injected either 30 min before training or immediately after training. Twenty-four hours after training retention latencies were recorded. Our data showed that both pre- and post-training administration of CXM produced amnesia in those groups that had been trained with relatively low foot-shock intensities, but no impairment in retention was observed when relatively high intensities of foot-shock were administered. These and similar results lead us to conclude that protein synthesis inhibitors may interfere with memory consolidation, but their effect disappears when animals are submitted to an enhanced learning experience, calling into question the idea that protein synthesis is required for memory consolidation.     

Effects of Aging on Functional Connectivity of the Amygdala for Subsequent Memory of Negative Pictures: A Network Analysis of Functional Magnetic Resonance Imaging Data

ABSTRACT— Aging is associated with preserved enhancement of emotional memory, as well as with age-related reductions in memory for negative stimuli, but the neural networks underlying such alterations are not clear. We used a subsequent-memory paradigm to identify brain activity predicting enhanced emotional memory in young and older adults. Activity in the amygdala predicted enhanced emotional memory, with subsequent-memory activity greater for negative stimuli than for neutral stimuli, across age groups, a finding consistent with an overall enhancement of emotional memory. However, older adults recruited greater activity in anterior regions and less activity in posterior regions in general for negative stimuli that were subsequently remembered. Functional connectivity of the amygdala with the rest of the brain was consistent with age-related reductions in memory for negative stimuli: Older adults showed decreased functional connectivity between the amygdala and the hippocampus, but increased functional connectivity between the amygdala and dorsolateral prefrontal cortices. These findings suggest that age-related differences in the enhancement of emotional memory might reflect decreased connectivity between the amygdala and typical subsequent-memory regions, as well as the engagement of regulatory processes that inhibit emotional responses.     

DYNAMICS OF CHOICE: RELATIVE RATE AND AMOUNT AFFECT LOCAL PREFERENCE AT THREE DIFFERENT TIME SCALES

To examine extended control over local choice, the present study investigated preference in transition as food‐rate ratio provided by two levers changed across seven components within daily sessions, and food‐amount ratio changed across phases. Phase 1 arranged a food‐amount ratio of 4:1 (i.e., the left lever delivered four pellets and the right lever one pellet); Phase 2 reversed the food‐amount ratio to 1:4, and in Phase 3 the food‐amount ratio was 3:2. At a relatively extended time scale, preference was described well by a linear relation between log response ratio and log rate ratio (the generalized matching law). A small amount of carryover occurred from one rate ratio to the next but disappeared after four food deliveries. Estimates of sensitivity to food‐amount ratio were around 1.0 and were independent of rate ratio. Analysis across food deliveries within rate‐ratio components showed that the effect of a small amount was diminished by the presence of a large amount—that is, when a larger amount was present in the situation (three or four pellets), the value of a small amount (one or two pellets) became paltry. More local analysis of visits to the levers between food deliveries showed that postfood visits following a large amount were disproportionately longer than following a small amount. Continuing food deliveries from the same source tended to make visits less dependent on relative amount, but a discontinuation (i.e., food from the other lever) reinstated dependence on relative amount. Analysis at a still smaller time scale revealed preference pulses following food deliveries that confirmed the tendency toward dependence on absolute amount with continuing deliveries, and toward dependence on relative amount following discontinuations. A mathematical model based on a linear‐operator equation accounts for many of the results. The larger and longer preference following a switch to a larger amount is consistent with the idea that local preference depends on relatively extended variables even on short time scales.     

Religions in Europe

The breakdown of European society is changing rapidly, particularly in the field of religion. Culture is of vital importance to the presence of religion in all nations. Religions also have exerted a certain degree of political power, thus influencing the economy and other related spheres of life.The different religions in Europe exhibit a variety of attitudes towards religious pluralism. The religious differences between Western and Eastern Europe depend mainly on issues of national identity related to religious adherence.This essay provides an overview of religion and politics, or Church and state, in Europe. It will conclude with some reflections about possible future developments within religious traditions in Europe. New religious communities and religious organisations are reaching different parts of Europe, sometimes very far from their place of origin. Christianity (Catholicism, Orthodoxy, and Protestantism) is the most widespread religion in contemporary Europe. Catholic religion is well diffused in Europe, but there are substantial differences in belief, behaviour and practice within different Catholic communities. There are various branches of Orthodoxy in Europe, such as the distinct autocephalous churches. In general Orthodox religion is closely aligned with national culture. Islam is also present in Western countries, and its impact is evident.     

Does g variance change in adulthood? Testing the age de-differentiation hypothesis across sex

In the last decade, changes in the structure of intelligence across the life-span has become a central topic in the research on human intelligence. One of the main hypotheses that has arisen to account for such changes has been the age de-differentiation hypothesis [Balinsky, Genetic Psychology Monographs 23 1941, 191]. It predicts an increase in the importance of g, and a decrease in the number and importance of the lower-order abilities from early maturity to senescence. Despite of the research effort to test this hypothesis, no study has ever been conducted controlling by sex. For that purpose, males and females of the Spanish standardisation sample of the WAIS-III were analysed separately. Results show that the importance of g does not change with age irrespective of sex. Thus, the age de-differentiation hypothesis is rejected for both males and females. The indifferentiation hypothesis is supported as a more appropriate view of the changes in the structure of intelligence across adulthood.     

Transforming three-way arrays to maximal simplicity

Transforming the core array in Tucker three-way component analysis to simplicity is an intriguing way of revealing structures in between standard Tucker three-way PCA, where the core array is unconstrained, and CANDECOMP/PARAFAC, where the core array has a generalized diagonal form. For certain classes of arrays, transformations to simplicity, that is, transformations that produce a large number of zeros, can be obtained explicitly by solving sets of linear equations. The present paper extends these results. First, a method is offered to simplifyJ ×J × 2 arrays. Next, it is shown that the transformation that simplifies anI ×J ×K array can be used to also simplify the (complementary) arrays of order (JK −I) ×J ×K, of orderI × (IK −J) ×K and of orderI ×J × (IJ −K). Finally, the question of what constitutes the maximal simplicity for arrays (the maximal number of zero elements) will be considered. It is shown that cases of extreme simplicity, considered in the past, are, in fact, cases of maximal simplicity.     

Compression and Expansion of Circadian Rhythm in Mice Under Long and Short Photoperiods

Although the functional aspects of synchronization of the circadian pacemaker by environmental light have been extensively studied, few studies have provided systematic information about the temporal organization of behavior under light-dark cycles with varying proportions of light and darkness. In the present study, the running-wheel activity profiles of mice were investigated under short, medium, and long photoperiods. The results clearly indicated that the temporal distribution of locomotor activity in mice is modulated by photoperiod. The activity profile was compressed under long photoperiods and expanded under short photoperiods. Although negative masking by light and alterations in the state of dark adaptation may have partially accounted for the phenomenon, the major mechanism seemed to be a compression and expansion of the circadian pacemaker's cycle, as expressed in the compression and expansion of the photic phase-response curve.     

Evaluation of Siddha Samadhi Yoga for anxiety and depression symptoms: a preliminary study

Siddha Samadhi Yoga is a program in which meditation is associated with pranayama (breathing exercises). 22 volunteers with anxiety complaints (M age = 42.8 yr., SD = 10.3) were assigned to two groups: 14 attended the yoga group, and 8 attended a waiting-list or control group. They were evaluated before the intervention and 1 month after it on the State-Trait Anxiety Inventory, the Beck Depression Inventory, Tension Feelings Self-evaluation Scales, and the Well-being Self-evaluation Scales. A significant reduction in scores on anxiety, depression, and tension was found in yoga group, as well as an increase in well-being in comparison with the control group.     

Self-regulated profiles and academic achievement

To date, research on the relation between learning self-regulation and academic achievement has generally show disparate results. This work intends to look into this relation from a new perspective, which consists in classifying the students as more or less self-regulated depending on diverse indicators and using cluster analysis. The aim of this work was to identify the possible self-regulated learning profiles in a sample of university students. By means of stepwise linear regression analysis, we determined which of the selected variables better predicted metacognitive self-regulation. Then, three significantly different self-regulated learning profiles were obtained by two-step cluster analysis with those variables. Lastly, ANOVA was used to analyse the relation between the self-regulated learning profiles and academic achievement. The implications of these data for the educational practice at university are discussed.