Parsing Heuristic and Forward Search in First‐Graders' Game‐Play Behavior

Seventy‐three children between 6 and 7 years of age were presented with a problem having ambiguous subgoal ordering. Performance in this task showed reliable fingerprints: (a) a non‐monotonic dependence of performance as a function of the distance between the beginning and the end‐states of the problem, (b) very high levels of performance when the first move was correct, and (c) states in which accuracy of the first move was significantly below chance. These features are consistent with a non‐Markov planning agent, with an inherently inertial decision process, and that uses heuristics and partial problem knowledge to plan its actions. We applied a statistical framework to fit and test the quality of a proposed planning model (Monte Carlo Tree Search). Our framework allows us to parse out independent contributions to problem‐solving based on the construction of the value function and on general mechanisms of the search process in the tree of solutions. We show that the latter are correlated with children's performance on an independent measure of planning, while the former is highly domain specific.     

Living in the Interface so as Not to Be Trapped Within Fragmentary Worlds

In this autobiographical sketch, I describe the influences that contributed to my ideas in psychoanalysis as well as the implications that the modular-transformational model of the organization of the psyche has for psychopathology and for treatment. I examine subtypes of depression and of pathological mourning, and how they require specific interventions. I review what type of needs (attachment, narcissistic, protection, psychobiological regulation, erotic) each participant satisfies for the other in the analytic relationship, as well as the meetings and clashes between the needs and wishes of the members of the dyad. I differentiate between attachment and intimacy and the various ways each subject feels intimacy is achieved. I discuss the need to deconstruct the psychopathological categories and replace them with configurations that combine different elements.     

Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory

CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, the first retention test was performed and hemicholinium (HC-3, 1.0 microg/mice), a specific inhibitor of high-affinity choline uptake in brain cholinergic neurons, was given intracerebroventricularly immediately after. Twenty four hours after treatment, mice were tested in an inhibitory avoidance task during five consecutive days, each 24 h apart. Retention performance was impaired by HC-3 when the first re-exposure took place at 2, 7, or 14 d, but the effect was no longer seen when re-exposure occurred 30 d after training. We did not find spontaneous recovery 21 d after training, when memory was retrieved 2 d after training and HC-3 was given immediately after. Although we cannot definitively discard a retrieval deficit, this lack of spontaneous recovery is in accordance with the storage-deficit interpretation. These results confirm and extend previous ones, suggesting that central cholinergic mechanisms are involved in the hypothetical reconsolidation memory processes of an inhibitory avoidance task in mice and also suggest that this participation depends on the "age" of the original memory trace. This implies that the vulnerability of a reactivated memory to a specific treatment, as the one used in this study, inversely correlates with the age of the original memory, and it is likely to determine memory reconsolidation processes.