The Care and Development of Children Living in Contexts of Poverty

Human development is determined by both genetic and environmental factors, especially during early childhood. Recently, research has indicated that the circumstances surrounding poverty can significantly influence children’s development. In this study, we aimed to measure the developmental level of children living in low-income, rural areas in northern Colombia. A total of 629 children (aged 0–5 years) were assessed using the Battelle Developmental Inventory. Results indicated that 17?% of the participants had a general developmental delay for their age group. This was especially true for scores on cognitive development (35.5?%) and communication (21.5?%). Moreover, the number of children with developmental delay increased at 6 months of age and continued to increase after 1 year in the communication and cognitive domains. The findings of this study suggest that impoverished social contexts—such as the one studied herein—offer opportunities that favor the development of the social domain, but restrict the development of the cognitive domain. Therefore, to promote cognitive development, individuals within children’s environment need to actively and intentionally stimulate them. Thus, there is a need for interventions that will improve environmental conditions; especially those that will help parents improve their caregiving practices and train educational staff to recognize and respond to the stimulation needs of children, especially those developmental domains that are affected by the environment.     

Next Generation Sequencing in the Clinic: a Patterns of Care Study in a Retrospective Cohort of Subjects Referred to a Genetic Medicine Clinic for Suspected Lynch Syndrome

Next generation sequencing (NGS) gene panels are increasingly used in medical genetics clinics for the evaluation of common inherited cancer syndromes, but the clinical efficacy of these tests, and the factors driving clinical providers to order them are unclear. We conducted a patterns-of-care study to compare patients evaluated with NGS gene panels with a reference group. We abstracted demographic, socioeconomic, and clinical information in a retrospective cohort of patients referred to a large medical genetics clinic for evaluation of inherited colorectal cancer and polyposis syndromes. Patients tested with NGS gene panels were more likely to be insured compared to the reference group (85.3 % vs. 69.2 %, p = 0.0068),less likely to have prior tumor tissue testing (29.4 % vs. 54.3 %, p = 0.0004), and less likely to have an abnormal tumor tissue test result (46.7 % vs. 74.5 %, p = 0.01). No significant differences were found between groups in age, gender, race, employment status, personal history of colorectal cancer, or proportion of patients fulfilling Lynch syndrome clinical criteria. Patients with NGS testing were less likely to have a pathogenic/likely pathogenic variant detected (13.7 % vs. 31.9 %, p = 0.002). Patients referred for NGS testing to evaluate inherited colorectal cancer/polyposis risk appear to undergo tumor tissue testing less frequently than non-NGS testing patients. Further studies are needed to assess the most effective and cost-effective approach to genomic diagnosis in this patient population.     

Neuroplastic Changes Following Social Cognition Training in Schizophrenia: A Systematic Review

Social cognitive impairment is a key feature of schizophrenia and social cognition training (SCT) is a promising tool to address these deficits. Neurobiological dysfunction in schizophrenia has been widely researched, but neuronal changes induced by SCT have been scarcely explored. This review aims to assess the neuroplastic effects of SCT in patients with schizophrenia spectrum disorders. PubMed and Web of Science databases were searched for clinical trials testing the effects of SCT in functional and structural brain measurements of adult patients with schizophrenia or schizoaffective disorders. A total of 11 studies were included: five used fMRI, two used EEG and ERP, one used ERP only, two used MEG and one study used MRI. Data extracting and processing regarding sociodemographic and clinical variables, intervention characteristics, neuroimaging procedures, neuroplastic findings, effect sizes and study quality criteria was completed by two raters. Results indicate a wide range of structural and functional changes in numerous regions and circuits of the social brain, including early perceptual areas, the limbic system and prefrontal regions. Despite the small number of trials currently available, evidence suggests that SCT is associated with neuroplastic changes in the social brain and concomitant improvements in social cognitive performance. There is a lack of extensive knowledge about the neural mechanisms that underlie social cognitive enhancement after treatment, but the reported findings may shed light on the neural substrates of social cognitive impairment in schizophrenia and how improved treatment procedures can be developed and applied.     

Variables related to the emergence of differential patterns in work motivation

Several longitudinal studies have shown that motivation at work acts chaotically. In very few cases, it may be linear or random. However, the factors that might explain why these different patterns emerge have not been analysed to date. In this exploratory study, we interviewed 73 employees whose motivational patterns were previously known. The results revealed that chaotic patterns were associated with high levels of motivation, self-efficacy beliefs, and perceptions of instrumentality, and also with intrinsic personal goal orientation and a perception of high work control. Linear patterns were associated with extrinsic goals and a perception of work as difficult, and random patterns were linked to high flexibility at work.     

On the perception of symmetrical and repeated patterns

Four experiments investigated rapid perceptual judgments about tachistoscopically presented patterns that were either symmetrical about or repeated across a vertical axis. The same patterns were presented under two different instructional conditions; some Ss were to judge the two halves of each pattern “same” or “mirror,” others were to judge each pattern as a whole “symmetrical” or “asymmetrical.” With dot patterns, RTs were faster for symmetrical than for repeated patterns when the two halves were close together, but not when they were separated, regardless of instructions. With simpler patterns made up of arrowheads and C-shapes, however, “same” RTs were faster than “mirror,” but “asymmetrical” RTs were marginally slower than “symmetrical,” regardless of spatial separation. The advantage of “same” over “mirror” did not seem to be simply a labeling effect. The results suggest that left-right symmetry is perceptually more salient than left-right repetition when the patterns are perceived holistically. By contrast, distinct patterns can be matched more rapidly when they are the same than when they are left-right mirror images.     

High self-reported rates of neglect and emotional abuse, by persons with binge eating disorder and night eating syndrome

This study compared rates of self-reported childhood maltreatment in three groups diagnosed using semi-structured interviews: binge eating disorder (BED; n=176), night eating syndrome (NES, n=57), and overweight/obese comparison (OC, n=38). We used the Childhood Trauma Questionnaire (CTQ) to assess childhood maltreatment and the Beck Depression Inventory-II to assess depression levels. Reports of maltreatment were common in patients with BED (82%), NES (79%), and OC (71%). The BED group reported significantly more forms of maltreatment above clinical cut-points (2.4) than the OC (1.4) group but not the NES (1.8) group. The BED and NES groups reported more emotional abuse than the OC group. A higher proportion of the BED group reported emotional neglect and a higher proportion of the NES group reported physical neglect. Depression levels, which were higher in BED and NES than OC, were associated with higher levels of physical and emotional abuse and neglect. In conclusion, reported rates of physical and sexual abuse differed little across groups, whereas reports of neglect and emotional abuse were higher in the BED and NES groups than in the OC group and were associated with elevated depression levels.     

Relationships between personality traits and positive/negative sexual cognitions

In this study we examined the relationship between gender, age, religion, neuroticism, extraversion, openness to experience, and obsessiveness on one side and the frequency and content of sexual cognitions experienced as being positive/pleasant or negative/unpleasant on the other. The sample was made up of 1,500 individuals (42.8% men and 57.2% women) aged between 18 and 72 years. Results indicated that all the socio-demographic variables as well as the traits neuroticism, openness to experience, and obsessiveness were important in the prediction of the overall frequency of positive sexual cognitions. Age and neuroticism, openness to experience, and obsessiveness were found to be significant in the prediction of the overall frequency of negative sexual cognitions. When considering the content of sexual cognitions (i.e., intimate, exploratory, sadomasochistic, and impersonal), all the socio-demographic variables and the trait openness to experience were found to be significantly related to all types of positive sexual cognitions. Neither socio-demographic variables nor personality traits were significantly associated with the content of negative sexual cognitions. Overall, this study highlights the weakness of the predictive value of personality traits on sexual cognitions, especially those experienced as being negative. We discuss the usefulness of classic personality traits in predicting sexual aspects.