Enhancement of the Post-training Cholinergic Tone Antagonizes the Impairment of Retention Induced by a Nitric Oxide Synthase Inhibitor in Mice

The present experiments examined the role of the central cholinergic system in the memory impairment induced by post-training administration of a nitric oxide synthase (NOS) inhibitor in mice. Male Swiss mice received a one-trial inhibitory avoidance training (0.8 mA, 50 Hz, 1-s footshock) followed immediately by an ip injection of the NOS inhibitor -N^G-nitroarginine methyl ester ( -NAME; 100 mg/kg). Retention (cut-off time, 300 s) was tested 48 h after training. The administration of -NAME results in memory impairment for the inhibitory avoidance task. The effects of -NAME (100 mg/kg, ip) on retention were reversed in a dose-related manner by the centrally acting anticholinesterase physostigmine (35, 70, or 150 μg/kg, sc) administered 30 min after the NOS inhibitor. Further, -NAME (100 mg/kg, ip)-induced memory impairment was completely antagonized by the centrally acting muscarinic cholinergic agonist oxotremorine (OTM; 25, 50, or 100 μg/kg, sc) when given 30 min after -NAME. The peripherally acting anticholinesterase neostigmine (150 μg/kg, sc) did not modify the memory-impairing effects of -NAME. These findings suggest that the memory impairment following post-training administration of a NOS inhibitor is mediated, at least in part, by a reduction of the activity of central muscarinic cholinergic mechanisms and are consistent with our previous view that nitric oxide may be involved in post-training neural processes underlying the storage of newly acquired information.     

Effects of Posttraining Administration of Glucose on Retention of a Habituation Response in Mice: Participation of a Central Cholinergic Mechanism

Male Swiss mice were allowed to explore a novel environment, provided by an open-field activity chamber, for 10 min. The procedure was repeated twice with a 24-h interval. The difference in the exploratory activity between the first (training) and the second (testing) exposures to the chamber was taken as an index of retention of this habituation task. Posttraining intraperitoneal administration of glucose (10–300 mg/kg) enhanced retention in a dose-related manner, although only the dose of 30 mg/kg of glucose produced significant effects. Thus, the dose–response curve adopted an inverted U-shaped form. Glucose (30 mg/kg) given to untrained mice did not modify their exploratory performance when recorded 24 h later. The effects of glucose on retention were time-dependent, suggesting an action on memory storage. The memory-improving actions of glucose were prevented by the simultaneous administration of both the central acting muscarinic cholinergic antagonist atropine (0.5 mg/kg) and by the central acting nicotinic cholinergic antagonist mecamylamine (5 mg/kg). In contrast, neither methylatropine (0.5 mg/kg), a peripherally acting muscarinic receptor blocker, nor hexamethonium (5 mg/kg), a peripherally acting nicotinic receptor blocker, prevented the effects of glucose on retention. Low subeffective doses of glucose (10 mg/kg) and the central anticholinesterase physostigmine (35 μg/kg), but not neostigmine (35 μg/kg), given together, act synergistically and facilitated retention. We suggest that glucose modulates memory storage of one form of learning elicited by stimuli repeatedly presented without reinforcement, probably through an enhancement of brain acetylcholine synthesis and/or its release.     

Optimism, Pessimism, and Hope in Durkheim

In Book Two, Chapter (1), of The Division of Labor in Society (1984) entitled "The Progress of the Division of Labor and Happiness", Emile Durkheim (1858–1917) stages a provocative encounter between the attitudes of optimism and pessimism, an encounter that reveals certain problematic assumptions regarding the status of hope in relation to the project of binding oneself to life under conditions of anomie. Durkheim's theoretical assault on the utilitarian-based optimism of his day is accomplished against the backdrop of a critical pessimism that is shown to be equally untenable. However, his critique leaves the question of the status of hope in relation to the question of human happiness unclarified and ambiguously framed, even as Durkheim defends hope against the despair of pessimism. The essay concludes with a critical appraisal of Durkheim's partial critique of pessimism and a few observations regarding the links between memory, expectation, pessimism, suicide, hope, and happiness.     

Brief version of the Fear of Negative Evaluation Scale - Straightforward Items (BFNE-S): psychometric properties in a Spanish population

The aim of this study was to examine the psychometric properties of the Brief version of the Fear of Negative Evaluation Scale - Straightforward Items (BFNE-S) in a non-clinical Spanish population. Rodebaugh et al. (2004) recommend the use of this scale composed of 8 straightforwardly-worded items, instead of the 12-item version of the BFNE. The sample consisted of 542 undergraduate students, 71.3% of whom were women and 28.7% were men; the mean age was 21.71 (4.78) years. Exploratory factor analysis produced one factor which accounted for 51.28% of variance. The internal consistency of the scale was alpha = .89. The BFNE-S correlated with the Social Avoidance and Distress Scale (r = .44), the Personal Report of Confidence as Speaker Modified (r = .44), the Public Speaking Self-Efficacy Questionnaire (r = -.38) and both subscales of the Self-Statements during Public Speaking (SSPS-P r = -.22; SSPS-N r = .53). ANOVAs revealed significant differences in the BFNE-S amongst a non-clinical population, persons suffering from specific social phobia, non-generalized social phobia and generalized social phobia.     

A Comparison of Noncontingent Plus Contingent Reinforcement to Contingent Reinforcement Alone on Students’ Academic Performance

Noncontingent reinforcement (NCR) can be described as time-based or response-independent delivery of stimuli with known reinforcing properties. Previous research has shown NCR to reduce problem behavior in individuals with developmental disabilities and to interfere with the acquisition of more desired alternative behavior. To date, however, little research has examined the effects of NCR on children’s academic performance. The present study examined the effects of NCR on the completion of math computation worksheets by 3 students in an elementary school setting. An ABCB reversal design was used to compare an NCR schedule in combination with contingent reinforcement to contingent reinforcement alone. Results showed that digits correct per session decreased to baseline levels for all 3 students during implementation of the NCR plus contingent reinforcement condition. Implications of these results for the reductive effects of NCR are discussed.     

Measuring coherence using LP-models

This paper introduces a technique for measuring the degree of (in)coherence of inconsistent sets of propositional formulas. The coherence of these sets of formulas is calculated using the minimal models of those sets in G. Priest's Logic of Paradox. The compatibility of the information expressed by a set of formulas with the background or domain knowledge can also be measured with this technique. In this way, Hunter's objections to many-valued paraconsistent logics as instruments for measuring (in)coherence are addressed.     

Normative data on the familiarity and difficulty of 196 Spanish word fragments

In this article, normative data on the familiarity and difficulty of 196 single-solution Spanish word fragments are presented. The database includes the following indices: difficulty, familiarity, frequency, number of meanings, number of letters given in the fragment, first and/or last letters given, and ratio of letters to blanks. A factor analysis was performed on difficulty, and two factors were obtained. Frequency, familiarity, and number of meanings loaded highly on the first factor, which we consider to measure lexical processes, whereas number of letters in the fragment, first and/or last letters given, and ratio of letters to blanks loaded highly on the second factor, which we judge to be determined by perceptual information. Regression analyses using factor scores as predictors showed that both factors accounted for a significant part of the completion probability scores. The full set of these norms may be downloaded from the Psychonomic Society Web archive atwww.psychonomic.org/archive/.     

The mental representation of living and nonliving things: differential weighting and interactivity of sensorial and non-sensorial features

Warrington and colleagues (Warrington & McCarthy, 1983, 1987; Warrington & Shallice, 1984) claimed that sensorial and functional-associative (FA) features are differentially important in determining the meaning of living things (LT) and nonliving things (NLT). The first aim of the present study was to evaluate this hypothesis through two different access tasks: feature generation (Experiment 1) and cued recall (Experiment 2). The results of both experiments provided consistent empirical support for Warrington and colleagues' assumption. The second aim of the present study was to test a new differential interactivity hypothesis that combines Warrington and colleagueS' assumption with the notion of a higher number of intercorrelations and hence of a stronger connectivity between sensorial and non-sensorial features for LTs than for NLTs. This hypothesis was motivated by previoUs reports of an uncrossed interaction between domain (LTs vs NLTs) and attribute type (sensorial vs FA) in, for example, a feature verification task (Laws, Humber, Ramsey, & McCarthy, 1995): while FA attributes are verified faster than sensorial attributes for NLTs, no difference is observed for LTs. We replicated and generalised this finding using several feature verification tasks on both written words and pictures (Experiment 3), including in conditions aimed at minimising the intervention of priming biases and strategic or mnemonic processes (Experiment 4). The whole set of results suggests that both privileged relations between features and categories, and the differential importance of intercorrelations between features as a function of category, modulate access to semantic features.