Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Neurodegen erative disorders such as Alzheimer’s disease (AD) are increasingly threatening public health. Most animal models of AD consist of transgenic mice that are usually housed singly or in unisexual groups in small barren cages. Such restricted environments, however, prevent the mice from showing a variety of speciesspecific behaviors and consequently may constrain comprehensive behavioral phenotyping. On the other hand, allowing the animals to freely organize their lives in a spacious physically and socially enriched environment makes behavioral phenotyping laborious and time consuming. Radio frequency identification (RFID) using a network of antennae and small glass-coated transponders labeling each individual allows for gathering spatiotemporal information about a large number of individuals in parallel. The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment.     

Brain and mind operational architectonics and man-made “machine” consciousness

To build a true conscious robot requires that a robot’s “brain” be capable of supporting the phenomenal consciousness as human’s brain enjoys. Operational Architectonics framework through exploration of the temporal structure of information flow and inter-area interactions within the network of functional neuronal populations [by examining topographic sharp transition processes in the scalp electroencephalogram (EEG) on the millisecond scale] reveals and describes the EEG architecture which is analogous to the architecture of the phenomenal world. This suggests that the task of creating the “machine” consciousness would require a machine implementation that can support the kind of hierarchical architecture found in EEG.

Distinguishing the cause and consequence of face inversion: The perceptual field hypothesis

I published a critical review of the face inversion effect (Rossion, 2008) that triggered a few reactions and commentaries by colleagues in the field ( [Riesenhuber and Wolff, 2009] and [83]). Here, I summarize my original paper and attempt to identify the source of both the agreements and disagreements with my colleagues, as well as other authors, regarding the nature of the face inversion effect. My view is that the major cause of the detrimental effect of inversion on an observer’s performance at individual face recognition is the disruption of a perceptual process. This perceptual process is makes and observer see the multiple features of a whole individual upright face at once. It also makes the percept of a given facial feature highly dependent on the location and identity of the other features in the whole face. The perceptual process is holistic because it is driven by a holistic face representation, derived from visual experience. Hence, an inverted face cannot be perceived holistically: the perceptual field of the observer is constricted for inverted faces, each facial feature having to be processed sequentially, independently, i.e. over a smaller spatial window than the whole face. Consequently, it is particularly difficult to perceive diagnostic cues that involve several elements over a wide space on an inverted face, such as long-range relative distances between features (e.g., relative distance between eyes and mouth), or diagnostic cues that are located far away from usual gaze fixation (e.g., mouth-nose distance or mouth shape when fixating between the eyes). These difficulties are mere consequences of face inversion - the cause being a loss of holistic perception-, and it does not follow that relative distances between internal features are necessarily particularly important to recognize faces, that they should be labeled “configural”, or should be given a specific status at the representational level. I argue that distinguishing the cause and consequence(s) of face inversion this way can provide a parsimonious and yet complete theoretical account of the face inversion effect.     

Failure to loose fear: The impact of cognitive load and trait anxiety on extinction

Exposure therapy is an effective technique for fear reduction. However, whether effective exposure requires attentional allocation to the feared situation remains a debated clinical issue. In the present study, the impact of attention allocation in extinction was investigated in an experimental conditioning study. Through a between-subjects manipulation of cognitive load, we created a condition in which participants could allocate their attention to the feared stimulus during extinction (low load condition), and a condition in which attentional allocation was impaired (high load condition). The influence of cognitive load on extinction was examined by comparing electrodermal responses and verbal ratings for the conditioned stimuli in the two extinction load conditions. The results show less successful extinction in the high load condition than in the low load condition. However, this effect was found only in low anxious participants, and it was prominent only on the skin conductance responses. The present results suggest that extinction is not automatic but requires cognitive resources.     

OBSERVING RESPONSES AND SERIAL STIMULI: SEARCHING FOR THE REINFORCING PROPERTIES OF THE S−

The control exerted by a stimulus associated with an extinction component (S−) on observing responses was determined as a function of its temporal relation with the onset of the reinforcement component. Lever pressing by rats was reinforced on a mixed random-interval extinction schedule. Each press on a second lever produced stimuli associated with the component of the schedule in effect. In Experiment 1 a response-dependent clock procedure that incorporated different stimuli associated with an extinction component of a variable duration was used. When a single S− was presented throughout the extinction component, the rate of observing remained relatively constant across this component. In the response-dependent clock procedure, observing responses increased from the beginning to the end of the extinction component. This result was replicated in Experiment 2, using a similar clock procedure but keeping the number of stimuli per extinction component constant. We conclude that the S− can function as a conditioned reinforcer, a neutral stimulus or as an aversive stimulus, depending on its temporal location within the extinction component.     

Rules and Self-Rules: Effects of Variation Upon Behavioral Sensitivity to Change

The Psychological Record - Four experiments compared the effects of self-rules and rules, and varied and specific schedules of reinforcement. Participants were first exposed to either several...     

Honor and Public Opinion

Honor has been an indispensable reference in the life of individuals and societies throughout the course of human history. As a basic concern of men and women, the phenomenon already appears in the earliest literary testimonies. The heroes of the Greek, Roman or German epic poems adapt their behavior to the demands of this particular deity, honor. Literature, at any time, in any culture, in any language, makes constant use of honor as an effective dramatic element. The recurrent presence is certainly a reflection of the actual significance the phenomenon of honor had in everyone’s life. This essay clarifies why honor is given such importance; why it has been considered to be more valuable for the individual than his/her own life. To this end, the mention of public opinion is unavoidable. This phenomenon, in its social psychological conception, is the key that permits us to enlighten the labyrinth of honor.     

Mental rotation of mirrored letters: evidence from event-related brain potentials

Event-related brain potentials (ERPs) were recorded while participants (n=13) were presented with mirrored and normal letters at different orientations and were asked to make mirror-normal letter discriminations. As it has been suggested that a mental rotation out of the plane might be necessary to decide on mirrored letters, we wanted to determine whether this rotation occurs after the plane rotation in mirror rotated letters. The results showed that mirrored letters in the upright position elicited a negative-going waveform over the right hemisphere in the 400-500 ms window. A similar negativity was also present in mirrored letters at 30 degrees, 60 degrees, and 90 degrees, but in these cases it was delayed. Moreover, the well-known orientation effect on the amplitude of the rotation-related negativity was also found, although it was more evident for normal than for mirrored letters. These results indicate that the processing of mirrored letters differs from that of normal letters, and suggest that a rotation out of the plane after the plane rotation may be involved in the processing of mirror rotated letters.     

Benefits of physical exercise on executive functions in older people with Parkinson’s disease

The benefits of physical exercise on cognitive functioning have been reported in the literature, but the potential benefits to slow the eventual decline in executive functioning (EF) caused by neurodegeneration from Parkinson’s Disease (PD) have rarely been studied. Thus the objective of this study was to analyze the effects of a multimodal physical exercise program on EF in older people with Parkinson’s disease. The EF of the older people was evaluated by neuropsychological testing, and for confounding variables such as attention, depressive symptoms and anxiety, before and after intervention. The 20 participants were assigned into Control (CG) and Trained (TG) Groups. The TG participated in generalized physical training for 6 months. The ANOVA showed a significant interaction (p < .05) that indicated a beneficial contribution of training on EF. No significant interactions were found in the results for confounding variables between groups and pre- and post-intervention, which supports the beneficial findings of physical exercise training on EF.