Are the inhibitory and faciliatory effects during retrieval of semantically related items present in amnestic mild cognitive impairment?

Prefrontal functions subserve inhibition control for retrieval of semantically related items inducing forgetting 19 a-MCI patients and 29 controls underwent neuropsychological evaluation and retrieval-practice paradigm (RPP) to estimate baseline remember (BR), retrieval-induced facilitation (FAC) and retrieval-induced forgetting (RIF). A-MCI patients underwent also 3 T-MRI to assess relationship between regional grey matter (rGM) volumes and RPP indexes Behaviourally, RIF and FAC were both observed controls, while RIF only was observed in a-MCI patients. In patients but not in controls, RIF was associated with cognitive efficiency and FAC with memory performance. Patients showed also associations between BR and rGM volumes in the precuneus, no association was found between rGM volumes and RIF and FAC. A-MCI patients did not benefit from repeated practice during retrieval of studied items, which is likely due to their memory disorder. In contrast, patient cognitive efficiency would drive retrieval suppression of interfering stimuli.     

The trajectory of a dot crossing a pattern of tilted lines is misperceived

The straight trajectory of a dot crossing a pattern of tilted lines is perceived as being sinusoidal. Manipulation of the size of the angle between the trajectory and the tilted lines, the velocity of the dot, and the distance between the tilted lines shows that the magnitude of the illusion is inversely proportional to the size of the incidence angle, to velocity, and to the distance between the lines. The illusion is interpreted as being the result of an integration process of local distortions occurring at the intersections with the tilted lines.     

A computational model of the Simon effect

Even though stimulus location is task irrelevant, reaction times are faster when the location of the stimulus corresponds with the location of the response than when it does not. This phenomenon is called the Simon effect. Most accounts of the Simon effect are based on the assumption that it arises from a conflict between the spatial code of the stimulus and that of the response. In this paper a computational model of this hypothesis is presented. It provides a computationally explicit mechanism of the Simon effect. Consistent with human performance, the model provides reaction times that indicate both an advantage for the ipsilateral, corresponding response (i.e., facilitation) and a disadvantage of the contralateral, noncorresponding response (i.e., inhibition). In addition, the model accounts for the fact that the size for the effect depends on task difficulty.     

Is there a modality effect? Evidence for visual recency and suffix effects

In Experiment 1, four groups of 16 subjects performed ordered recall of six-syllable lists in both suffix and nonsuffix conditions. Sequential presentation of the lists varied for each group. In the auditory presentation, the syllables were delivered from one location only and were read aloud by the subjects. For the visual, spatially nondistributed presentation, the syllables appeared in one location only and were read silently. For visual, spatially distributed presentations, the syllables were spread out either vertically or horizontally and were read silently. Very robust recency and suffix effects were found in the auditory presentation, as well as in visual, spatially distributed presentations. In Experiment 2, 16 subjects performed ordered recall of visually presented lists with the items spread out vertically and conflicting spatial and temporal orders. A reliable recency effect was found for the final block of trials. In Experiment 3, 16 subjects performed ordered recall in the same conditions as in Experiment 2, except that they were instructed to recall the temporal order in which the spatial positions would be filled in. A bow-shaped curve and a strong recency effect were obtained.     

Manual behavior, lateralization of manual skills and cognitive performance of preschool children

Direction and degree of manual specialization (functional asymmetry between the hands) on a pegboard task, and fine motor ability (total number of pegs inserted) of both hands were correlated with verbal and visuospatial performances for 47 preschool children. No significant differences were found between right-, and left-, and mixed-handers even though the best motor skills were shown by the 6 mixed-handed subjects, who also had the highest scores on cognitive tasks. Verbal and visuospatial performances were not correlated with degree or direction of manual specialization. They were instead correlated with the level of motor ability of both hands. Motor maturation should be viewed, then, as a process that implies a richer motor performance of both hands and could be interpreted as a more specific diagnostic parameter than the traditional indices of handedness in cognitive fields.     

The attribute priming effect in patients with Alzheimer's disease

Experiments with semantic priming (SP) paradigms have documented early hypopriming in patients with AD when concepts are used as primes and attribute concept features as targets, suggesting that concept attributes are vulnerable to damage very early in the disease course. The aims of this study were to confirm early priming reduction in the attribute condition in patients with AD and to determine which of several semantic indexes (such as the level of distinctiveness, correlation or feature dominance of concept features) best predicts the priming effect size in AD. We administered an SP attribute condition paradigm to 20 mildly demented patients with AD and to 10 NCs. We used concept–attribute pairs for which normative data of semantic indexes relative to both concept primes (i.e., number, type, mean level of dominance, distinctiveness and correlation of features constituting the concepts) and target features (i.e., level of feature dominance, correlation and distinctiveness) were available. Results showed that compared to NCs, the AD group obtained very reduced priming facilitation. Furthermore, the item regression analyses showed that the priming decrement in the AD group was predicted by the feature dominance of the target in the related pairs; that is, the lower the target feature dominance, the lower the priming effect elicited. These results confirmed hypopriming in the attribute condition from the very early phase of AD and support the view that attributes which are more salient for the identification of a given concept are also those most resistant to semantic memory degradation in AD pathology.     

New Perspectives on Analytic Pragmatism

Analytic pragmatism is a framework of analysis elaborated by Robert Brandom, whose goal is to explain the relations between meaning and use according to a systematic and general method of inquiry. In April 2009, a workshop was organized to discuss the recent developments of this new theoretical approach. Brandom delivered three lectures, where he explored some aspects of analytic pragmatism and addressed the motivating themes of this enterprise, while the contribution from the other speakers ranged over specific aspects of the theory. This special issue is the outcome of that workshop. In this introduction we briefly outline the context of the debate and present the contribution to this issue selected from a much wider range of papers, using the reviewing process of Philosophia.