BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure

Post-traumatic stress disorder (PTSD) is a syndrome resulting from exposure to a severe traumatic event that poses threatened death or injury and produces intense fear and helplessness. The neural structures implicated in PTSD development belong to the limbic system, an important region for emotional processing. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as survival factor for selected populations of central nervous system (CNS) neurons and plays a role in the limbic system by regulating synaptic plasticity, memory processes and behavior. Impaired BDNF production in the brain can lead to a variety of CNS dysfunctions including symptoms associated with PTSD. However, so far fewer studies have investigated this neurotrophin in patients with PTSD. Furthermore, given the multiple role of BDNF in various CNS disorders, it cannot be excluded that traumatic events per se may influence neurotrophin levels, without a direct association to the PTSD syndrome.     

Validation and Standardization of the Dutch Trauma Symptom Checklist for Young Children in a Normative and Clinical Sample

The study aimed to describe the psychometric properties of the Dutch version of the Trauma Symptom Checklist for Young Children (TSCYC) in normative and clinical populations in the Netherlands. Caregivers’ ratings on the TSCYC were obtained for 1,802 children from the normal population, and for 515 children from a clinical population of traumatized children. In the clinical sample, additional measures were taken. The internal consistency and test-retest reliability of TSCYC scales were adequate. Confirmatory factor analysis showed acceptable fit on the putative scale structure. Regarding criterion validity, the clinical sample scored significantly higher on all clinical scales when compared to the normal population sample. Within the clinical sample, significant associations were found between TSCYC scales and convergent scales of other instruments. The Posttraumatic Stress-Total subscale demonstrated excellent discriminative ability between traumatized children and children from the normal population. The Dutch version of the TSCYC proved a valid and reliable instrument to measure trauma symptoms in young children through caregiver report, similar to the original American version. Further comparisons with diagnostic interviews are warranted.     

Principles for Object-Linguistic Consequence: from Logical to Irreflexive

We discuss the principles for a primitive, object-linguistic notion of consequence proposed by (Beall and Murzi, Journal of Philosophy, 3 pp. 143–65 (2013)) that yield a version of Curry’s paradox. We propose and study several strategies to weaken these principles and overcome paradox: all these strategies are based on the intuition that the object-linguistic consequence predicate internalizes whichever meta-linguistic notion of consequence we accept in the first place. To these solutions will correspond different conceptions of consequence. In one possible reading of these principles, they give rise to a notion of logical consequence: we study the corresponding theory of validity (and some of its variants) by showing that it is conservative over a wide range of base theories: this result is achieved via a well-behaved form of local reduction. The theory of logical consequence is based on a restriction of the introduction rule for the consequence predicate. To unrestrictedly maintain this principle, we develop a conception of object-linguistic consequence, which we call grounded consequence, that displays a restriction of the structural rule of reflexivity. This construction is obtained by generalizing Saul Kripke’s inductive theory of truth (strong Kleene version). Grounded validity will be shown to satisfy several desirable principles for a naïve, self-applicable notion of consequence.     

In search of shared and nonshared environmental factors in security of attachment: a behavior-genetic study of the association between sensitivity and attachment security

The current article presents results from a twin study of genetic and environmental components of maternal sensitivity and infant attachment and their association. The sample consisted of 136 twin pairs from 2 sites: Leiden, the Netherlands, and London, UK. Maternal sensitivity was assessed in the home at 9-10 months, and infant attachment security was observed in the laboratory at 12 months. The study yielded little evidence that genetic factors are involved in variations between twins in maternal sensitivity ratings but did find that shared variance in maternal sensitivity was able to account for some of the similarity between twins in attachment security. Weak nonshared associations between sensitivity and attachment appeared to suppress the magnitude of the correlation between attachment and sensitivity in twin children. The results could indicate that the attachment security of one twin may depend on the relationship the parent has with the other twin. The results are brought to bear on the validity of attachment theory as a theory of primarily shared environmental effects in children's development and the continuing challenge posed to attachment theory by within-family differences in socioemotional processes.     

Fitch’s paradox and <Emphasis Type="Italic">ceteris paribus</Emphasis> modalities

The paper attempts to give a solution to the Fitch’s paradox though the strategy of the reformulation of the paradox in temporal logic, and a notion of knowledge which is a kind of ceteris paribus modality. An analogous solution has been offered in a different context to solve the problem of metaphysical determinism.     

The limits of definition: Gadamer’s critique of Aristotle’s ethics

ABSTRACT

There is a recent scholarly trend drawing similarities between Aristotle’s conceptions of ethics and demonstrative science. One such similarity has become widely and rightly recognized: for Aristotle both ethics and demonstrative science seek essential definitions of phenomena. The task of the paper is to show that German philosopher and classicist Hans-Georg Gadamer not only prefigured this interpretative trend, he also identified a problematic feature of Aristotle’s method so construed. The problematic feature is semantic. For Aristotle essential definitions must consist of univocal terms, but such univocity cannot be maintained if the definienda and definientes are concepts to be usefully employed in everyday ethical judgements. Gadamer therefore points out a problematic tension in Aristotle’s ethics. On the one hand, ethical inquiry should have practical application, but, on the other hand, the semantic assumptions underlying inquiry imply that it cannot.     

Are delusional contents replayed during dreams?

The relationship between dream content and waking life experiences remains difficult to decipher. However, some neurobiological findings suggest that dreaming can, at least in part, be considered epiphenomenal to ongoing memory consolidation processes in sleep. Both abnormalities in sleep architecture and impairment in memory consolidation mechanisms are thought to be involved in the development of psychosis. The objective of this study was to assess the continuity between delusional contents and dreams in acutely psychotic patients. Ten patients with a single fixed and recurring delusional content were asked to report their dreams during an acute psychotic break. Sixteen judges with four different levels of acquaintance to the specific content of the patients’ delusions were asked to group the dreams, expecting that fragments of the delusional thought would guide the task. A mathematical index (f, t) was developed in order to compare correct groupings between the four groups of judges. Most judges grouped the dreams slightly above chance level and no relevant differences could be found between the four groups [F(3, 12) = 1.297; p = n.s.]. Scoring of dreams for specific delusional themes suggested a continuity in terms of dream and waking mentation for two contents (Grandiosity and Religion). These findings seem to suggest that at least some delusional contents recur within patients’ dreams. Future studies will need to determine whether such continuity reflects ongoing consolidation processes that are relevant to current theories of delusion formation and stabilization.     

Frege: two theses,two senses

One particular topic in the literature on Frege's conception of sense relates to two apparently contradictory theses held by Frege: the isomorphism of thought and language on one hand and the expressibility of a thought by different sentences on the other. I will divide the paper into five sections. In (1) I introduce the problem of the tension in Frege's thought. In (2) I discuss the main attempts to resolve the conflict between Frege's two contradictory claims, showing what is wrong with some of them. In (3), I analyse where, in Frege'ps writings and discussions on sense identity, one can find grounds for two different conceptions of sense. In (4) I show how the two contradictory theses held by Frege are connected with different concerns, compelling Frege to a constant oscillation in terminology. In (5) I summarize two further reasons that prevented Frege from making the distinction between two conceptions of sense clear: (i) the antipsychologism problem and (ii) the overlap of traditions in German literature contemporary to Frege about the concept of value. I conclude with a hint for a reconstruction of the Fregean notion of ‘thought’ which resolves the contradiction between his two theses.     

“So It Really Does Exist—The Sea-Serpent We’ve Never Believed in!” Ferenczi’s Influence on Freud Revisited

In the last phase of his work, Ferenczi created a new language for trauma, based on the fragmentation of mental life. In the paper on “The principles of relaxation and neocatharsis,” Ferenczi reformulated the goal of analysis by proposing that “no analysis can be regarded … as complete unless we have succeed in penetrating the traumatic material”, where the “traumatic material” was not to be sought in the neurotic reactions and adaptive solutions of the ego but in more primitive reactions, such as the psychotic turning away from reality, splitting, and fragmentation. This was exactly the material that Freud assimilated in the essay “A disturbance of memory on the Acropolis”, after the death of Ferenczi. Freud visited Athens in 1904, and the walk up to the Parthenon represented the successful coronation of his self-analysis. Actually, the hallucination turned out to be so uncanny that he never again visited Athens. In a letter to Fliess, written shortly before the meeting in Nuremberg, on January 24, 1897, Freud reported on a case history turning on a “scene about the circumcision of a girl,” who later was convincingly identified by Schur as Emma Eckstein. Did Freud have the germinal idea that Emma Eckstein’s hallucination of the penis contained the wish to overcome her trauma and the hope to have a restored genital? Is this the holy visitation, which haunted him on the Acropolis? Why did he give up the profound insight that the dreams of gigantic snakes had a traumatic origin?