Pseudo-appeals to conscience

Conclusion Pseudo-appeals to conscience stress that the dictates of conscience are always either morally obligatory or at least not morally wrong. These appeals are untenable. They result in an indefensible moral relativism. They should be abandoned.Thanks are due to the National Endowment for the Humanities for financial support; my conclusions do not necessarily represent the view of the Endowment. For incisive criticisms of early drafts I am indebted to Richard M. Hare, Geoffrey Marshall, Tibor Machan, and Conrad Brunk. For stimulating discussions on these topics my thanks go to all of the above and to Brenda Cohen, Ruth Marcus, William Earle, Basil Mitchell, Bernard Dauenhauer, and Charles Daniels. Most of all, however, my thanks go to Harry Henig for invaluable inspiration in this area.     

Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia

Visuospatial learning and memory impairments are an early marker for age-related cognitive decline and Alzheimer's disease. Similar to humans, aged dogs show visuospatial learning and memory deficits (). One hundred and nine beagle dogs ranging between 0.25 and 11.99 years were tested on a visuospatial delayed non-matching to position (DNMP) task to better characterize the progression of visuospatial deficits in the dog. Age predicted 48.2% of the variability in learning the DNMP, with dogs ranging from 1 to 11.99 years generally making more errors with increasing age. By contrast, puppies (<1 year) likely were showing developmental deficits, possibly due to an immature prefrontal cortex. Mild visuospatial deficits were detected by 6 years, which precedes the typical onset of amyloid-beta (Abeta) accumulation in the dog brain by two years, and can serve as an early marker for cognitive decline in the dog. These findings suggest that (1) age-related changes in visuospatial function in the dog models that seen in humans, further validating the dog as a model for human aging and dementia; and (2) other mechanisms, such as oxidative stress, soluble Abeta oligomers or cholinergic deficits, are likely contributing to the early impairment.     

A cross-sectional evaluation of the factorial invariance of anxiety sensitivity in adolescents and young adults

This study examined the cross-sectional factorial invariance of anxiety sensitivity in an ethnically diverse sample of adolescents (n = 173; mean age 15.5 years) and young adults (n = 291; mean age 20.1 years). Research in adult and youth samples suggests that anxiety sensitivity is best understood as a hierarchical construct with several lower-order factors. Factor models based on previous research using both adult and youth samples were compared and a hierarchical model with three lower-order factors provided the best fit to the data. Results supported the hypothesis that the factor structure of the Anxiety Sensitivity Index was invariant across age and gender. The factor scores also demonstrated differential correlations with symptoms of anxiety and depression. Results are discussed with regard to construct validation and understanding the structure of anxiety sensitivity in youth.     

Thought suppression mediates the relationship between negative affect and borderline personality disorder symptoms

The purpose of this study was to examine the relationships among negative affect, childhood sexual abuse (CSA), thought suppression, and diagnostic symptoms of borderline personality disorder (BPD) in a community sample (n=127). Findings suggest that the temperamental variable negative affect intensity/reactivity was a stronger predictor of BPD symptoms than CSA. In addition, results indicated that higher thought suppression mediated the relationship between negative affective intensity/reactivity and BPD symptoms, after controlling for a history of CSA. Overall, findings suggest that (a) negative affectivity may be a better predictor of BPD symptoms than CSA, and (b) chronic efforts to suppress unpleasant thoughts may be a regulation strategy underlying the relationship between intense negative emotions and BPD symptoms.     

Risk and Resiliency Factors Influencing Suicidality Among Urban African American and Latino Youth

For decades, suicide rates among minority African American and Latino young people have been stable and, when compared with Whites, relatively low. This is no longer the case, underscoring the need for documenting and understanding the problem of suicidality in this population. We report on the prevalence and predictors of suicidality among 879 urban adolescents in the Reach for Health study. All youth resided in economically disadvantaged neighborhoods; 69% were African American, 16% Latino, and 15% reported mixed or other ethnicity. In the past year, 15% had seriously considered suicide; 13% had made a suicide plan, 11% had attempted suicide at least once, and 4% reported multiple attempts. Risk factors significantly related to suicidal ideation are being female, having basic needs unmet, engaging in same-gender sex, and depression. Resiliency factors include family closeness and, marginally, religiosity. Risk factors related to reports of suicide attempts are being female, being Hispanic, and depression; family closeness is strong resiliency factor. Family composition, ethnic identity, coping style, peer support, and school attachment are not significant correlates of suicidal ideation or attempts.     

HIV-1 infection and its impact on the HPA axis, cytokines, and cognition

Immediately after infection, Human immunodeficiency virus, type 1 (HIV-1) enters the central nervous system (CNS) and is localized in highest concentration in the hippocampus and basal ganglia. Since these areas are associated with HPA axis and autonomic activities as well as cognition, it has been hypothesized that these functions will be impacted adversely in HIV-1 infection. In the treatment of HIV infection, although the highly potent antiretroviral (HAART) drugs have been effective in reducing peripheral viral load and prolonging life expectancy, these drugs do not cross the blood-brain barrier in therapeutic concentrations. Therefore, it has been proposed that the beneficial effects of HAART on the CNS will be limited. Our investigations on seropositive individuals, showing hypo-reactivity of the autonomic system and HPA axis activity suggest that HIV-1 infection is a model of chronic stress. Furthermore, an elevated baseline TNF-alpha level as well as its increased reactivity to an alpha-adrenergic challenge among HIV-1+ individuals, may lead to additional neurodegeneration. It is proposed that the effects of HIV-1 infection on the brain will have implications for neurocognitive and mental health functioning in seropositive individuals even in patients undergoing HAART therapy. These outcomes may result in the need to develop facilities for long term "care-giving".     

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Fanatic Hatred and Violence in Contemporary America

The paper is a social psychological and psychoanalytic examination of collective violence in the United States in which fanatic hatred and sheer destructiveness are the central operating principles. The primary character structure of who's involved in fanatic violence are shown here to be people who were raised in authoritarian-oriented backgrounds, who find themselves marginal, and unnecessary persons in postmodern American society.     

Pragmatic Existential Therapy

A pragmatic model of existential therapy is offered to support the thesis that brief, solution focused therapy is a clinical application of existential psychology. Superseding pioneering existential therapies more concerned with insight than with clinical technique, pragmatic existential therapy is a dynamic clinical intervention facilitating in patients, decision, choice, self-commitment, and concrete action, the goal of which is movement toward the future and fulfillment of patients' latent potentials. In addition to clarifying the model's theoretical focus on (a) lived experience, (b) self-creation, and (c) existential anxiety, practical guides to brief existential treatment are offered. Sources from existential philosophy and psychology, as well as brief solution focused treatment, are used to evidence core elements of an existential therapy that is not contemplative and insight-focused, but pragmatic and action-based.     

Misadventures In Conditional Expectation: The Two-Envelope Problem

Several fallacies of conditionalization are illustrated, using the two-envelope problem as a case in point This revised version was published online in July 2006 with corrections to the Cover Date.