Inflammation in white matter: clinical and pathophysiological aspects

While the central nervous system (CNS) is generally thought of as an immunopriviledged site, immune-mediated CNS white matter damage can occur in both the perinatal period and in adults, and can result in severe and persistent neurological deficits. Periventricular leukomalacia (PVL) is an inflammatory white matter disease of premature infants that frequently results in cerebral palsy (CP). Clinical and experimental studies show that both hypoxic/ischemic and innate immune mechanisms contribute to the destruction of immature oligodendroglia and of axons in the deep cerebral white matter in PVL. No data are yet available as to whether there is any genetic predisposition to PVL or to its neurological sequelae. Multiple sclerosis (MS) is an inflammatory white matter disease that often begins in young adulthood, causes multifocal destruction of mature oligodendroglia and of axons, and eventually leads to substantial cumulative neurological disability. Certain genetic polymorphisms contribute to susceptibility to MS, and adaptive immune responses to myelin-associated self antigens, or to exogenous antigens that mimic these self antigens, play a central role in the pathophysiology of this disease.     

Romantic love and sexual desire in close relationships

Drawing on recent claims in the study of relationships, attachment, and emotion, the authors hypothesized that romantic love serves a commitment-related function and sexual desire a reproduction-related function. Consistent with these claims, in Study 1, brief experiences of romantic love and sexual desire observed in a 3-min interaction between romantic partners were related to distinct feeling states, distinct nonverbal displays, and commitment- and reproductive-related relationship outcomes, respectively. In Study 2, the nonverbal display of romantic love was related to the release of oxytocin. Discussion focuses on the place of romantic love and sexual desire in the literature on emotion.     

Will you be there for me when things go right? Supportive responses to positive event disclosures

Close relationship partners often share successes and triumphs with one another, but this experience is rarely the focus of empirical study. In this study, 79 dating couples completed measures of relationship well-being and then participated in videotaped interactions in which they took turns discussing recent positive and negative events. Disclosers rated how understood, validated, and cared for they felt in each discussion, and outside observers coded responders' behavior. Both self-report data and observational codes showed that 2 months later, responses to positive event discussions were more closely related to relationship well-being and break-up than were responses to negative event discussions. The results are discussed in terms of the recurrent, but often overlooked, role that positive emotional exchanges play in building relationship resources.     

We-ness,Embodied Simulation,and Psychoanalysis: Reply to Commentaries

Neuroscience is progressively revealing the intimate relationship between embodied simulation and the understanding of verbal communication, including its affective quality. The neuroscientific investigation of linguistic aspects of interpersonal relations and the functional mechanism of embodied simulation are discussed in relation to the understanding of therapeutic action in psychoanalysis.     

Preschoolers' attention and emotion in an achievement and an effect game: A longitudinal study

Understanding positive emotions' shared and differentiating features can yield valuable insight into the structure of positive emotion space and identify emotion states, or aspects of emotion states, that are most relevant for particular psychological processes and outcomes. We report two studies that examined core relational themes (Study 1) and expressive displays (Study 2) for eight positive emotion constructs—amusement, awe, contentment, gratitude, interest, joy, love, and pride. Across studies, all eight emotions shared one quality: high positive valence. Distinctive core relational theme and expressive display patterns were found for four emotions—amusement, awe, interest, and pride. Gratitude was associated with a distinct core relational theme but not an expressive display. Joy and love were each associated with a distinct expressive display but their core relational themes also characterised pride and gratitude, respectively. Contentment was associated with a distinct expressive display but not a core relational theme. The implications of this work for the study of positive emotion are discussed.     

A Unified Latent Curve,Latent State-Trait Analysis of the Developmental Trajectories and Correlates of Positive Orientation

The subgrouping strategy has been employed in a number of studies (Fredriksen &; Gilbert, 1960; Fredriksen &; Melville, 1964; Ghiselli, 1956; Klein, Rock &; Evans, 1968; Rock, Evans &; Klein, 1969; Malnig, 1969). In each of these studies it was shown that after partitioning a sample into g subgroups and performing a separate regression analysis within each group, one could identify one or more subgroups having a larger multiple correlation than the total sample regression. An important question is whether this type of result will be maintained under cross validation.     

Voting and Values: Reciprocal Effects over Time

Two studies investigated reciprocal effects of values and voting. Study 1 measured adults' basic values and core political values both before (n = 1379) and following (n = 1030) the 2006 Italian national election. Both types of values predicted voting. Voting choice influenced subsequent core political values but not basic values. The political values of free enterprise, civil liberties, equality, law and order, military intervention, and accepting immigrants changed to become more compatible with the ideology of the chosen coalition. Study 2 measured core political values before (n = 697) and following (n = 506) the 2008 Italian national election. It largely replicated the reciprocal effects of voting and political values of Study 1. In addition, it demonstrated that left‐right ideology mediated the reciprocal effects of voting and political values. Moreover, voter certainty moderated these effects. Political values predicted vote choice more weakly among undecided than decided voters, but voting choice led to more value change among undecided voters.