Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene–environment interactions

Experiencing disasters causes severe mental disorders, among which post-traumatic stress disorder (PTSD) is the most common. We conducted a longitudinal study to examine the effect of 5-hydroxyl tryptamine transporter gene-linked polymorphic region (5-HTTLPR) genotype on child and adolescent PTSD symptom course after the 2008 Wenchuan Earthquake. We genotyped 963 participants who personally experienced the earthquake. PTSD symptoms were measured by University of California, Los Angeles PTSD reaction index at 2.5, 3.5, 4.5 and 5.5 years after the earthquake, respectively. Latent growth model was utilised to examine the main effect and gene–environment interaction effect of 5-HTTLPR on PTSD's symptom course. 5-HTTLPR genotype predicted initial PTSD symptom severity (β = 0.108, p = .019) and rates of symptom recovery (β = −0.120, p = .031) between 2.5 and 5.5 years. Compared with L′ allele carriers, those with S′S′ genotype showed higher initial symptom severity but also faster recovery rate. 5-HTTLPR genotype only predicted symptom severity at 2.5 years after the earthquake, after controlling for sex, age, ethnicity and trauma severity (β = 0.108, p = .019). This is the first evidence of the effect of 5-HTTLPR genotype on child and adolescent PTSD symptoms longitudinally, offering a novel perspective on the effect of 5-HTTLPR on PTSD symptom development following trauma exposure.     

The hope of the future: The experience of pregnancy influences women’s implicit space–time mappings

It has long been observed that speakers employ spatial concepts “front” and “back” to talk about temporal concepts “past” and “future.” However, the direction of space-time mappings varies across cultures. According to Temporal Focus Hypothesis (TFH), people’s implicit associations between space and time are conditioned by their temporal focus. Here we tested whether pregnancy can affect Chinese women’s temporal focus and thereby influence their space-time mappings. One of the most striking characteristics of pregnant women noted by previous research is their future-oriented thought. Based on this, we predicted that pregnant women should be more future-focused. Consistent with this prediction, the results demonstrated that pregnant women tended to be more future-focused than non-pregnant women and demonstrated a greater tendency to conceptualize the future as in front of them, supporting the TFH. The current research offers a new perspective that culture-external factors such as pregnancy can also influence people’s spatialization of time.     

Critical Poisson’s ratio between toughness and brittleness

We have a new understanding on a unified fracture criterion based on two kinds of strain energy density. A definite expression which is a function of Poisson’s ratio to describe a crucial parameter in the unified fracture criterion is derived. The critical value of Poisson’s ratio between brittle and ductile materials can be derived as 2/7 which is verified by experimental data. Besides, the effect of Poisson’s ratio on the fracture loci in stress spaces is studied using unified fracture criterion. It is found that the decrease in Poisson’s ratio increases the asymmetry of fracture loci between tensile stress states and compressive stress states in principal stress spaces and between Lode parameters are 1 and ?1 in deviatoric-stress spaces. In addition, stress triaxiality has a great effect on the fracture behaviour with different Poisson’s ratios.     

Rules We Live by: How Religious Beliefs Relate to Compliance with Precautionary Measures Against COVID-19 in Tibetan Buddhists

Journal of Religion and Health - The present studies investigated how particular religious beliefs shape compliance with preventive measures in adherents of Gelug and Nyingma schools of Tibetan...