The Portuguese version of Addenbrooke’s Cognitive Examination–Revised (ACE-R) in the diagnosis of subcortical vascular dementia and Alzheimer’s disease

The aim of this study was to investigate the accuracy of the Portuguese version of Addenbrooke’s Cognitive Examination–Revised (ACE-R) in detecting and differentiating early stage subcortical vascular dementia (SVD) from early stage Alzheimer’s disease (AD). Ninety-two subjects (18 SVD patients, 36 AD patients, and 38 healthy controls) were assessed using the ACE-R. Between-group’s differences were evaluated using the Quade’s rank analysis of covariance. The diagnostic accuracy and discriminatory ability of the ACE-R were examined via receiver operating characteristic (ROC) analysis. The ACE-R was able to successfully discriminate between patients and healthy subjects. The mean ACE-R total scores differed between SVD and AD patients; there were also significant differences in attention and orientation and in memory measures between the groups. An optimal cut-off of 72/73 was found for the detection of AD (sensitivity: 97%; specificity: 92%) and SVD (sensitivity: 100%; specificity: 92%).     

Jan Patočka’s sacrifice: philosophy as dissent

This article attempts to bring together the life, situation, and philosophical work of the Czech phenomenologist Jan Pato?ka in order to present his conception of philosophy and sacrifice and to understand his action of dissent and his own sacrifice as spokesman for Charter 77 in light of these concepts. Pato?ka philosophized despite being barred from teaching under the German occupation and under the communist regime, even after he was forced to retire and banned from publication. He also refused the official philosophical categories of communism and, what is more, criticized the very manner in which its ideology allowed it to function. Against the destruction of moral and political life by communist and liberal regimes alike, he outlined the necessity of a “life in the idea” that would be responsive to the notion of sacrifice. Such a position of distance from the things of the world which remains anchored among them is meant to respond to dissatisfaction with the world as it is found and is the very movement of human freedom. Taken together, these three aspects of his philosophical practice made him a dissident, a role he took on more completely when, as part of the Charter 77 movement, he publicly opposed the state, in a course of action that led to his death.     

Object and action picture naming in English and Greek

When two orthographically similar words are displayed using rapid serial visual presentation (RSVP), the repeated letters in the second critical word (W2) are not detected, leading to a deficit in reporting this word known as repetition blindness (RB). In Turkish, letters containing diacritic markings (e.g., y, ö) are considered separate letters, yet are visually highly similar to their non-diacritic analogues (s,o). Two experiments used the phenomenon of RB to investigate whether diacritic letters are represented as more similar to their non-diacritic analogues than are two unrelated letters. In Experiment 1, substantially more RB was found for words differing in just a diacritic (i y im-isim) compared to orthographic neighbours (words differing in a visually non-similar letter, such as ilim-isim). In Experiment 2, the amount of RB for identical words (isim-isim) was comparable to words that differed by a single diacritic marking (i y im-isim). We conclude that diacritic letters are mentally represented as variants of their non-diacritic analogue. Letter / word recognition researchers may be interested in pursuing these findings using standard techniques such as backward masking and orthographic priming.     

Film Review

Tell Me Who Is Haunting You and I'll Tell You Who You Are. A Reading of the film Sixth Sense dir. M. Night Shyamalan (1999)     

Adolescent Egocentrism and the Illusion of Transparency: Are Adolescents as Egocentric as we Might Think?

The illusion of transparency, or people’s tendency to believe their thoughts and feelings as more apparent to others than they actually are, was used to investigate adolescent egocentrism. Contrary to previous research demonstrating heightened adolescent egocentrism, adolescents exhibited similar levels of egocentrism to adults. In experiment 1, 13-14 year-olds and adult participants both truthfully described and lied about a series of pictures. Both adolescent and adult liars indicated that they were more confident that other participants would know when they were lying, than other participants actually indicated. In experiment 2, 13-14 year-olds, 15-16 year-olds and adult participants read to an audience. The illusion of transparency effect manifested itself differently according to gender: Female participants indicating that they looked more nervous than audiences thought, whilst male participants indicating that they were more entertaining than audiences thought. Results were interpreted using simulation theory, and suggested that adolescents might not be as egocentric as previously thought.     

Acceptability and Feasibility of Peer Assisted Supervision and Support for Intervention Practitioners: A Q-methodology Evaluation

Evidence-based interventions often include quality improvement methods to support fidelity and improve client outcomes. Clinical supervision is promoted as an effective way of developing practitioner confidence and competence in delivery; however, supervision is often inconsistent and embedded in hierarchical line management structures that may limit the opportunity for reflective learning. The Peer Assisted Supervision and Support (PASS) supervision model uses peer relationships to promote the self-regulatory capacity of practitioners to improve intervention delivery. The aim of the present study was to assess the acceptability and feasibility of PASS amongst parenting intervention practitioners. A Q-methodology approach was used to generate data and 30 practitioners volunteered to participate in the study. Data were analyzed and interpreted using standard Q-methodology procedures and by-person factor analysis yielded three factors. There was consensus that PASS was acceptable. Participants shared the view that PASS facilitated an environment of support where negative aspects of interpersonal relationships that might develop in supervision were not evident. Two factors represented the viewpoint that PASS was also a feasible model of supervision. However, the third factor was comprised of practitioners who reported that PASS could be time consuming and difficult to fit into existing work demands. There were differences across the three factors in the extent to which practitioners considered PASS impacted on their intervention delivery. The findings highlight the importance of organizational mechanisms that support practitioner engagement in supervision.     

Reducing Ethical Hazards in Knowledge Production

This article discusses the ethics of knowledge production (KP) from a cultural point of view, in contrast with the more usual emphasis on the ethical issues facing individuals involved in KP. Here, the emphasis is on the cultural environment within which individuals, groups and institutions perform KP. A principal purpose is to suggest ways in which reliable scientific knowledge could be produced more efficiently. The distinction between ethical hazard and (un)ethical behaviour is noted. Ethical hazards cannot be eliminated but they can be reduced if the cultural ambience is suitable. The main suggestions for reducing ethical hazards in KP relate to the review process. It is argued that some defects of the current, largely anonymous, review process could be ameliorated by a process of comprehensive, open and ongoing review (COOR). This includes partial professionalisation of the work of reviewing. Review at several stages is a vital part of the long filtering that incorporates some claims into the canon of reliable knowledge. The review process would be an acknowledged and explicit part of KP—a respected, public and rewarded activity. COOR would be expensive but cost-effective. The costs should be built explicitly into research culture. Finally, the considerations about a more ‘KP friendly’ culture lead to advocacy of a ‘long-term, short-term’ synthesis; that is, of the synthesis of long-term vision, such as a more cooperative and less competitive culture, with incremental changes which may be implemented in the short term.     

Chewing Over In Vitro Meat: Animal Ethics,Cannibalism and Social Progress

Despite its potential for radically reducing the harm inflicted on nonhuman animals in the pursuit of food, there are a number of objections grounded in animal ethics to the development of in vitro meat. In this paper, I defend the possibility against three such concerns. I suggest that worries about reinforcing ideas of flesh as food and worries about the use of nonhuman animals in the production of in vitro meat can be overcome through appropriate safeguards and a fuller understanding of the interests that nonhuman animals actually possess. Worries about the technology reifying speciesist hierarchies of value are more troublesome, however. In response to this final challenge, I suggest that we should be open not just to the production of in vitro nonhuman flesh, but also in vitro human flesh. This leads to a consideration of the ethics of cannibalism. The paper ultimately defends the position that cannibalism simpliciter is not morally problematic, though a great many practices typically associated with it are. The consumption of in vitro human flesh, however, is able to avoid these problematic practices, and so should be considered permissible. I conclude that animal ethicists and vegans should be willing to cautiously embrace the production of in vitro flesh.