Intrathecal methotrexate--overdosing in pediatric lymphoblastic leukemia

Intrathecal methotrexate-overdosage in the meningosis therapy leads to CNS damages dependent on dose. It was given a own case report and a literature review with clinical symptoms and the therapy in this complication. Neuropathologic findings included demyelinisation und necrosis of the white matter.     

Recipient's mood, relationship type, and helping

We conducted two studies to examine how a potential helper is affected by having a communal orientation toward a relationship with a potential recipient and by the potential recipient's sadness. We hypothesized that (a) having a communal orientation would increase helping and that (b) people high in communal orientation, but not others, would respond to a potential recipient's sadness by increasing helping. These hypotheses were tested in two studies. In Study 1, individual differences in communal orientation toward relationships were measured by using a new communal orientation scale reported for the first time in this article. In Study 2, manipulations were used to lead subjects to desire either a communal or an exchange relationship with another person. In both studies, subjects were exposed to a sad person or to a person in a neutral mood whom they were given a chance to help. As hypothesized, in both studies communally oriented subjects helped the other significantly more than did others. Also as hypothesized, in both studies communally oriented subjects but not others, increased helping in response to the other person's sadness although this effect reached statistical significance only in the second study.     

Validation studies of a multifactor cognitive-behavioral Anger Control Inventory

Two studies are reported on a new Anger Control Inventory based on a cognitive-behavioral person-situation interaction model. In Study 1, the inventory responses of 118 clinical subjects and 190 normal subjects were correlated with an anger problem criterion based on observable signs. Factor analyses were conducted to clarify the construct base of the inventory. In Study 2, comparisons were made between the inventory responses of 100 spouse batterers and 96 normal subjects. Significant differences between the pretreatment and posttreatment scores of 65 batterers given treatment in anger control were obtained on the inventory scales, which were found to be correlated with the problem criterion and discriminating between the clinical and normal groups. The construct validity and clinical utility of the Anger Control Inventory are discussed.     

Age differences in adolescent body satisfaction

The purpose of this study was to explore differences in body satisfaction among female adolescents 14 to 18 years of age. Principal components analysis of a body cathexis measure completed by 751 high school cheerleaders indicated that six factors defined the adolescents' attitudes toward their bodies: satisfaction with the midsection and overall appearance, peripheral body parts, hair and face, mouth, hands, and height. An Age X Body Satisfaction multivariate analysis of variance (MANOVA) was conducted; a Bonferroni adjusted alpha of .007 was established for subsequent ANOVAs. Satisfaction with the mouth increased significantly as age increased, and a similar but nonsignificant trend was found for peripheral body parts. The findings contradict previous research reporting no age differences in the body satisfaction of adolescents. Role demands and physical maturation of the cheerleaders may explain differences based on age.     

Assessment of death attitudes: an empirical approach

The Threat Index and the Death Anxiety Scale were administered to 228 subjects. Based on the high/low criterion scores, 105 subjects were assigned to the following four groups: (a) high death threat/high death anxiety, (b) high death threat/low death anxiety, (c) low death threat/high death anxiety, and (d) low death threat/low death anxiety. During the experimental phase of the study, subjects viewed a filmstrip on death rituals in various cultures. A recall test was then administered. Results indicated no significant group differences on recall performance. Initial no-show rates for the second part of the experiment were observed in the four groups reflecting a significant negative relationship between death anxiety and initial no-show rates. The possibility of defensive responding on the Death Anxiety Scale was suggested.     

Community responses following suicide, homicide, and other deaths: the perspective of potential comforters

To determine whether actual responses of potential comforters in the community differ according to cause of death, 83 college students participated in a structured, individual interview. They were asked demographic questions about themselves, the bereaved, and the deceased, and then about various aspects of how they, and others in the community, responded to the death. Students were grouped by their reports of the cause of death (suicide, homicide, accident, natural anticipated death, or natural unanticipated death). When the death was by suicide or homicide, others were perceived as relatively less supportive of the bereaved person. When the death was by suicide, respondents themselves tended more to blame the bereaved person. When the death was by homicide, the bereaved person was perceived as reacting relatively worse. Potential comforters were relatively more shocked when the death was by homicide or accident.     

Stimulus class membership established via stimulus-reinforcer relations

In an arbitrary matching-to-sample procedure, two mentally retarded subjects learned conditional discriminations with two sets of stimuli. Each set included a spoken name (N1 or N2), an object (O1 or O2), and a printed symbol (S1 or S2). One subject selected conditionally (a) O1 upon N1, and O2 upon N2, and (b) S1 upon O1, and S2 upon O2. The other subject selected conditionally (a) S1 upon N1, and S2 upon N2, and (b) O1 upon S1, and O2 upon S2. For both subjects, selections of O1 and S1 produced one type of food, F1; selections of O2 and S2 produced a different type of food, F2. Both subjects also learned identity-matching performances, selecting O1, O2, S1, S2, F1, and F2 conditionally upon those stimuli as samples; F1 followed selections of O1, S1, and F1; F2 followed selections of O2, S2, and F2. Matching performances consistent with stimulus class formation involving the names, objects, symbols, and foods were demonstrated on probe trials, even though these performances had not been taught explicitly. Next, new objects, X1 and X2, were presented on identity-matching trials, producing F1 and F2, respectively. Without further training, X1 was selected conditionally upon N1, S1, and O1, and X2 was selected upon N2, S2, and O2. When the contingencies were changed so that selections of X1 and X2 were now followed by F2 and F1, respectively, X2 was selected conditionally upon N1, S1, and O1, and X1 was selected upon N2, S2, and O2. Class membership of X1 and X2 had apparently changed. This study provides evidence that reinforcers may become members of stimulus classes, and that new stimuli may become class members through relations with reinforcers.     

Alcoholism: A conflict of models

Adherents to the traditional model of alcoholism explain alcoholic behavior as a consequence of alcoholism. Alcoholism is identified as an unseen, unmeasured entity inherent in alcoholics. This concept parallels the thinking of Copernicus, Kepler, Galileo, and Newton, who believed in an unseen, unmeasurable creator behind the physical world. These traditional approaches contrast with the emergent model of alcoholism and twentieth-century scientific thought. Emergent scientific model adherents explain alcoholic behavior without resort to unseen factors. Since the traditional and emergent scientific models begin with different assumptions, model adherents experience communication difficulties. Future developments with determine which model will dominate the field of alcohol studies and treatment.