Developing treatments for impaired cognition in schizophrenia

Schizophrenia is one of the most debilitating of all common brain disorders, exacting a heavy toll on the afflicted and having a tremendous public health impact. Clinical outcome is more strongly predicted by cognitive deficits than psychotic symptoms, with no established treatment for these deficits. In this review, we discuss the status of treatment development for impaired cognition in schizophrenia. These treatments include a range of pharmacological targets within diverse neurotransmitter systems. New technologies, including transcranial magnetic stimulation and transcranial direct current stimulation, and psychological therapies, such as computer-based cognitive training, may also benefit cognition in schizophrenia. Each of these approaches shows promise and their integration may optimize benefits for patients in the future.     

Attention Bias for Threatening Information in Children Following a Distressing Medical Procedure

Attention bias is common in adults with post‐traumatic stress disorder (PTSD) but is less studied in children. Children (n = 22) who experienced a potentially distressing procedure in an outpatient clinic (removal of K‐wires from orthopaedic fractures) and a group of medically unwell children (illness group; n = 27) were compared with healthy controls (n = 32). Children's baseline level of PTS symptoms were indexed prior to the medical procedure, and again at 1‐week follow‐up. Immediately after the K‐wire removal, children completed a dot probe task using two categories of target words (medical threatening and emotionally threatening). While K‐wire children showed an overall bias away from negative words relative to healthy controls, the illness group did not significantly differ from healthy controls. Attention bias in K‐wire and illness groups was unrelated to later PTS symptoms.     

A Three-Factor Model of Social Identity

Despite the importance of the social identification construct in research and theory on group processes and intergroup relations, the issue of its dimensionality remains unresolved. It is proposed that social identity can be represented in terms of three factors: centrality; ingroup affect; and ingroup ties. I examined the efficacy of this model in five studies involving a total of 1078 respondents, one nonstudent sample, and three group memberships (university, gender, and nationality). Results of confirmatory factor analyses support the acceptability of the tripartite model, which fits the data significantly better than one- or two-dimensional (cognition/affect) alternatives. Correlations with theoretically relevant variables provide support for the convergent and discriminant validity of the three factors. Advantages and implications of the three-factor model are considered, with particular reference to social identity theory.     

Movement duration does not affect automatic online control

Pisella et al. (2000) have shown that fast aiming movements are automatically modified on-line in response to a change in target position. Specifically, when a movement is less than 300 ms in duration the reach is completed to a target’s new location even when one never intended to respond to the target jump. In contrast, when movements are slower, the reach is completed according to instructions. At present, it is unclear if it is possible for one’s intentions to guide the initial stages of these slow movements. To determine if the intentional control mechanism can guide the initial stages of a slow aiming movement, participants aimed to targets that could jump at movement onset, with a slow and very slow movement time goal. In particular, participants were to point towards (“pro-point”) or away from (“anti-point”) the target jump, with a movement time goal of 500 or 1200 ms. Results showed that in the anti-point condition, movement trajectories first deviated in the same direction as the target jump, followed by a response in the intended (opposite) direction. This suggests that while movement outcome is controlled by the intentional system, even in these slow aiming movements the automatic system is engaged at movement onset.     

Vagueness and Naturalness

I attempt to accommodate the phenomenon of vagueness with classical logic and bivalence. I hold that for any vague predicate there is a sharp cut-off between the things that satisfy it and the things that do not; I claim that this is due to the greater naturalness of one of the candidate meanings of that predicate. I extend the thought to the problem of the many and Benacerraf cases. I go on to explore the idea that it is ontically indeterminate what the most natural meanings are, and hence ontically indeterminate where the sharp cut-off in a sorites series is.     

Fair Shares: A Preliminary Framework and Case Analyzing the Ethics of Offshoring

Much has been written about the offshoring phenomenon from an economic efficiency perspective. Most authors have attempted to measure the net economic effects of the strategy and many purport to show that “in the long run” that benefits will outweigh the costs. There is also a relatively large literature on implementation which describes the best way to manage the offshoring process. But what is the morality of offshoring? What is its “rightness” or “wrongness?” Little analysis of the ethics of offshoring has been completed thus far. This paper develops a preliminary framework for analyzing the ethics of offshoring and then applies this framework to basic case study of offshoring in the U.S. The paper following discusses the definition of offshoring; shifts to the basic philosophical grounding of the ethical concepts; develops a template for conducting an ethics analysis of offshoring; applies this template using basic data for offshoring in the United States; and conducts a preliminary ethical analysis of the phenomenon in that country, using a form of utilitarianism as an analytical baseline. The paper concludes with suggestions for further research.     

Cognitive Control in the Face of Fear: Reduced Cognitive-Emotional Flexibility in Women with a History of Child Abuse

Child abuse can negatively affect neurobiological systems involved in regulating emotions. Adults who were maltreated as children show diminished capacity to flexibly integrate the prefrontal and limbic circuits underlying emotion regulation. Using a facial identification Stroop task with nonemotional and emotional stimuli, we found that women who reported more childhood abuse (N = 44) were no different from women reporting less childhood abuse (N = 45) on nonemotional conflict adaptation, but were significantly less able to adapt to emotional conflict. Women who reported more abuse were especially impaired in adapting to emotional conflict when incongruent stimuli involved a fearful face. These results help characterize the relation between cognitive control and emotion regulation and highlight the far-reaching effects of childhood abuse on cognitive-emotional flexibility.     

Individual and Social Factors in the Development of Graphic Symbolization

College student attitudes toward United States involvement in three international conflict areas were measured at various times during the years 1965 through 1971. An examination of the mean attitude scores obtained toward United States involvement in the Arab-Israel, India-Pakistan, and Vietnam conflicts revealed some reluctance on the part of the students to have the United States involved in any of these areas of international conflict.

Younger students were most dovish concerning United States involvement in Vietnam and were less so on the issues of the India-Pakistan and the Arab-Israel conflicts, whereas older students were more dovish regarding the issues of United States involvement in the Arab-Israel and India-Pakistan conflicts and least dovish with respect to the Vietnam conflict. Attitudes toward the involvement of the United States in both the Vietnam and Arab-Israel conflicts became significantly more dovish over time.     

The Place of Mania Among the Depressions from a Biological Standpoint

One hundred college women completed a situational story that dealt with a traditional feminine occupation, while another 100 women completed a story that dealt with a more nontraditional, masculine occupation. The stories were used to measure fear of success. All women furnished information on their college major, career aspirations, and year in school, and completed the Masculinity and Ascendency scales from the Guilford-Zimmerman Temperament Survey. Both two- and three-dimensional chi square tests of association were performed to determine the relationship between fear of success and other variables.

Results (p < .05) indicated that fear of success is greater toward a nontraditional occupation, especially for women of low ascendency, and fear of success is greater the closer women get to graduation.     

Can't Shake It Off? Attachment Moderates the Link Between Hostility and Forgiveness

ABSTRACT

Although previous research has indicated that forgiveness is an essential part of relationships that thrive, forgiveness tends to become increasingly difficult as the intensity and duration of hostility rises. Understanding conditions that help make forgiveness more possible, as well as those that actually make forgiveness more difficult, then becomes an important asset for clinicians promoting healthier relational dynamics and longevity. Using data from 257 participants across two time points, we measured the association between hostility and forgiveness to test the moderating role of attachment. Greater hostility was linked with less benevolent forgiveness and more resentment. Moreover, anxious attachment moderated the association between hostile interactions and resentment—the inability to forgive. Implications for helping professionals and clinicians are discussed.