The perils of learning to move while speaking: One-sided interference between speech and visuomotor adaptation

Psychonomic Bulletin & Review - Our understanding of the adaptive processes that shape sensorimotor behavior is largely derived from studying isolated movements. Studies of visuomotor...     

Should trainee doctors use the developing world to gain clinical experience? The annual Varsity Medical Debate – London, Friday 20th January, 2012

The 2012 Varsity Medical Debate between Oxford University and Cambridge University provided a stage for representatives from these famous institutions to debate the motion “This house believes that trainee doctors should be able to use the developing world to gain clinical experience.” This article brings together many of the arguments put forward during the debate, centring around three major points of contention: the potential intrinsic wrong of ‘using’ patients in developing countries; the effects on the elective participant; and the effects on the host community. The article goes on to critically appraise overseas elective programmes, offering a number of solutions that would help optimise their effectiveness in the developing world.     

Genetic Counseling in a Busy Pediatric Metabolic Practice

Patients with inborn errors of metabolism and their families require unique clinical care including management of acute illnesses, screening for long term complications, discussion of the etiology of the condition, connections to social supports, and clarification of the recurrence risks and prenatal testing and treatment options. Our multidisciplinary pediatric metabolic clinic combines the skills of metabolic geneticists, pediatric dieticians, social workers, clinical pharmacists, nurses and genetic counselors to provide optimal and well-rounded care for our patients and their families. Given the inherited nature of most inborn errors of metabolism and the necessary long-term management for these disorders, the genetic counselor’s role in this clinic setting is integral in providing ongoing support and education for patients and their families. This includes coping with the disease burden, helping patients and families adapt to a condition in the family and ensuring adequate understanding of the genetic risks and the available prenatal diagnostic and reproductive choices. Our clinic provides services to a large geographic area with many isolated populations where unique metabolic diseases are highly prevalent secondary to a founder effect. In this paper, we share our experience in providing longitudinal care to children with complex medical needs due to metabolic disorders and highlight the role of the genetic counselor in this clinic setting.     

Percentile Norms and Accompanying Interval Estimates from an Australian General Adult Population Sample for Self‐Report Mood Scales (BAI,BDI, CRSD,CES‐D,DASS, DASS‐21, STAI‐X,STAI‐Y,SRDS, and SRAS)

Despite their widespread use, many self‐report mood scales have very limited normative data. To rectify this, Crawford et al. have recently provided percentile norms for a series of self‐report scales. The present study aimed to extend the work of Crawford et al. by providing percentile norms for additional mood scales based on samples drawn from the general Australian adult population. Participants completed a series of self‐report mood scales. The resultant normative data were incorporated into a computer programme that provides point and interval estimates of the percentile ranks corresponding to raw scores for each of the scales. The programme can be used to obtain point and interval estimates of the percentile ranks of an individual's raw scores on the Beck Anxiety Inventory, the Beck Depression Inventory, the Carroll Rating Scale for Depression, the Centre for Epidemiological Studies Rating Scale for Depression, the Depression, Anxiety, and Stress Scales (DASS), the short‐form version of the DASS (DASS‐21), the Self‐rating Scale for Anxiety, the Self‐rating Scale for Depression, the State–Trait Anxiety Inventory (STAI), form X, and the STAI, form Y, based on normative sample sizes ranging from 497 to 769. The interval estimates can be obtained using either classical or Bayesian methods as preferred. The programme (which can be downloaded at http://www.abdn.ac.uk/~psy086/dept/MoodScore_Aus.htm ) provides a convenient and reliable means of obtaining the percentile ranks of individuals' raw scores on self‐report mood scales.     

Cortisol response to behavior problems in FMR1 premutation mothers of adolescents and adults with fragile X syndrome: A diathesis-stress model

Mothers of adolescents and adults with fragile X syndrome (FXS) are faced with high levels of parenting stress. The extent to which mothers are negatively impacted by this stress, however, may be influenced by their own genetic status. The present study uses a diathesis-stress model to examine the ways in which a genetic vulnerability in mothers with the premutation of the FMR1 gene interacts with child-related environmental stress to predict their morning cortisol levels. Seventy-six mothers of an adolescent or adult with FXS participated in an 8-day telephone diary study in which they reported on the behavior problems of their son or daughter with FXS each day. We analyzed salivary cortisol collected from mothers at awakening and 30 minutes after awakening on 4 of these days. The results indicated that mothers with greater genetic vulnerability had a lower level of cortisol on mornings following days when their son or daughter with FXS manifested more episodes of behavior problems, whereas mothers with less genetic risk evinced the opposite pattern of higher morning cortisol in response to their child's behavior problems. This finding contributes to our understanding of gene-by-environment interactions and highlights the importance of interventions to alleviate parenting stress in mothers raising children with FXS.     

Effects of chlorpromazine on lateralization,cued reaction time,and dichotic listening

In a double-blind cross-over design sixteen subjects took 50 mg of chlorpromazine or placebo in tablet form 2 hours prior to completing a dichotic listening and simple reaction time task with and without warnings. In the simple reaction time task, blocks of 80 stimuli were presented to each ear with and without warning cue under drug and placebo conditions. On the dichotic listening task the expected right ear advantage for reporting digits was obtained. While the drug had no main effect on the number of errors, there were more trials on which an ear advantage was present than in the placebo condition. In the reaction time task there were main effects of drug, warning cue and foreperiod: warnings facilitated reaction; chlorpromazine retarded reaction; and reaction times were most facilitated by warning foreperiods in excess of 1200ms. Several findings were of interest: On uncued trials, with placebo, right ear responses were faster than those for stimuli presented to the left ear. Drug also interacted with foreperiod duration. These results were interpreted in the light of Tucker and Williamson’s (1984) review of the role of Pribram and McGuinness’s Arousal and Activation sytems in lateralized behavior.     

Age differences and similarities in the effects of cues and prompts

A series of 6 experiments investigated the use of cues and prompts by younger and older adults. Cues provide useful information about an impending target, even though the information is not always valid. Prompts provide an instruction about what aspect of the target is to be responded to. The costs and benefits of cues were most consistent with models in which the attentional resources that are shifted in response to the cue were as large or larger in older adults as they were in younger adults. The results with both cues and prompts converged on the conclusion that the time course of processing and using a cue or prompt is the same in younger and older adults. The attentional resources tapped by these procedures cannot be the diminished processing resource to which many age differences in cognitive performance are attributed.     

Semantic networks: visualizations of knowledge

The history of semantic networks is almost as long as that of their parent discipline, artificial intelligence. They have formed the basis of many fascinating, yet controversial, discussions in conferences and in the literature, ranging from metaphysics through to complexity theory in computer science. Many excellent surveys of the field have been written, and yet it is our belief that none of them has examined the important link between their use as a formal scheme for knowledge representation and their more heuristic use as an informal tool for thinking. In our consideration of semantic networks as computerized tools, we will discuss three levels of abstraction that we believe can help us understand how semantic networks are used. I.