Dietary ethyl-eicosapentaenoic acid but not soybean oil reverses central interleukin-1-induced changes in behavior, corticosterone and immune response in rats

Omega (n)-3 and n-6 fatty acids are important membrane components of neurons and immune cells, and related to psychiatric and inflammatory diseases. Increased ratio of n-6/n-3 in the blood has been reported in depressed patients and in students following stress exposure. The n-3 fatty acid, eicosapentaenoic acid (ethyl-EPA) suppresses inflammation and has antidepressant properties. Interleukin (IL)-1beta can stimulate corticosterone secretion, induce anxiety and stress-like behavior and inflammatory responses. This study was to evaluate the effect of diets enriched with coconut oil, ethyl-EPA and soybean oil on central IL-1beta induced stress and anxiety-like behavior, induced changes in the concentration of prostaglandin (PG) E2 and corticosterone and the release of IL-10. Groups of rats were fed with either 5% coconut oil (as control diet), 0.2% EPA with 4.8% coconut oil or 1% EPA with 4% coconut oil and 5% soybean oil for 7 weeks. The central administration of IL-1beta induced sickness, stress and anxiety-like behavior as indicated by a reduction in body weight, decreased time spent, and the number of entries, into the open arms of the elevated plus maze and decreased exploration and entry into the central zone of the "open field" apparatus. IL-1beta also increased PGE2 and corticosterone concentrations and decreased the release of IL-10 from leucocytes. Food enriched with ethyl-EPA but not soybean oil, significantly attenuated most of these changes. These results demonstrate that ethyl-EPA has anti-inflammatory, anti-stress and anti-anxiety effects in rats.     

化学哲学研究的新走向

近20年来,尽管不断有关于讨论化学哲学的著作和论文出现,但仍没有形成与物理学哲学、生物学哲学、经济学哲学以及数学哲学能相抗衡的态势和规模.     

敦睦他者:城市新移民的社会融合之路——对上海市Y社区的个案考察

本文是一项对城市新移民社会融合问题的探索性研究.作者在上海市Y社区的个案调查发现,新移民与城市社区的"二元关系"正在发生变化,即从相互隔离、排斥和对立转向一种理性、兼容、合作的"新二元关系",本文用中国传统文化的概念称之为"敦睦他者".在此基础上,作者提出新移民与城市社会融合经历三个阶段的构想,这三个阶段分别是"二元社区"、"敦睦他者"和"同质认同"."敦睦他者"是新移民与城市社会融合的关键阶段,在此期间需要政府、社区和新移民共同做出努力.     

童年中期同伴关系、同伴关系知觉与心理行为适应的关系

本研究以422名小学二、三、四年级的儿童进行为期3年的纵向研究,考察了时间2的同伴关系知觉在时间1的同伴关系和时间3的心理行为适应之间的中介效应。结果表明,自我知觉的社会能力在同伴接纳与社交/领导行为和孤独感之间的中介作用显著,自我知觉的友谊质量在双向互选朋友与社交/领导行为和孤独感之间的中介作用显著。     

双相障碍及其社会-心理治疗的研究现状

双相障碍是以起伏性躁狂或抑郁为特征的慢性周期性精神疾病。近年来,社会-心理疗法作为药物治疗的辅助手段被引入到该类疾病的治疗过程中。本文基于近期关于双相障碍的病因学的研究,评述了各种不同形式的社会-心理疗法在双相障碍治疗中的应用及其疗效,指出今后的研究需要进行严格的临床设计,以保证不同研究间的可比性和可重复性;应尽可能延长追踪观察的时间,并进行大样本多变量研究,以保证研究结果的普遍性。     

Stopping speech suppresses the task-irrelevant hand

Some situations require one to quickly stop an initiated response. Recent evidence suggests that rapid stopping engages a mechanism that has diffuse effects on the motor system. For example, stopping the hand dampens the excitability of the task-irrelevant leg. However, it is unclear whether this ‘global suppression’ could apply across wider motor modalities. Here we tested whether stopping speech leads to suppression of the task-irrelevant hand. We used Transcranial Magnetic Stimulation over the primary motor cortex with concurrent electromyography from the hand. We found that when speech was successfully stopped the motor evoked potential from the task-irrelevant hand was significantly reduced compared to when the participant failed to stop speaking, or responded on non stop signal trials, or compared to baseline. This shows that when speech is quickly stopped, there is a broad suppression across the motor system. This has implications for the neural basis of speech control and stuttering.     

Personality profiles and the prediction of categorical personality disorders

Personality disorders (PDs) are usually construed as psychiatric categories characterized by a unique configuration of traits and behaviors. To generate clinical hypotheses from normal personality trait scores, profile agreement statistics can be calculated using a prototypical personality profile for each PD. Multimethod data from 1,909 psychiatric patients in the People's Republic of China were used to examine the accuracy of such hypotheses in the Interpretive Report of the Revised NEO Personality Inventory. Profile agreement indices from both self-reports and spouse ratings were significantly related to PD symptom scores derived from questionnaires and clinical interviews. However, accuracy of diagnostic classification was only modest to moderate, probably because PDs are not discrete categorical entities. Together with other literature, these data suggest that the current categorical system should be replaced by a more comprehensive system of personality traits and personality-related problems.     

“中国现代性”的追寻——对当代中国哲学发展主线的一种描述

The process of Chinese modernization is essentially the pursuit and the construction of Chinese modernity. This process has been the focus of modern and contemporary Chinese philosophy. It is embodied in the cultural and philosophical developments both during the period of Chinese Democratic Revolution and after the foundation of the People's Republic of China. It is especially the case during the Reform and Openness era. In the currently prevalent model of modernity,there are deep internal contradictions a...     

道教劝善书的和谐理念——以《关圣帝君觉世真经》为例

《关圣帝君觉世真经》在对人们"诸恶莫作,众善奉行"的劝诫中渗透着诸多和谐的理念,它的生命伦理、家庭伦理、社会伦理、生态伦理、经济伦理及道德赏罚观,反映出道教对社会和谐的追求,为我们构建和谐社会提供了宝贵的思想理论资粮。     

Bayesian analysis of mixtures in structural equation models with non‐ignorable missing data

Structural equation models (SEMs) have become widely used to determine the interrelationships between latent and observed variables in social, psychological, and behavioural sciences. As heterogeneous data are very common in practical research in these fields, the analysis of mixture models has received a lot of attention in the literature. An important issue in the analysis of mixture SEMs is the presence of missing data, in particular of data missing with a non‐ignorable mechanism. However, only a limited amount of work has been done in analysing mixture SEMs with non‐ignorable missing data. The main objective of this paper is to develop a Bayesian approach for analysing mixture SEMs with an unknown number of components and non‐ignorable missing data. A simulation study shows that Bayesian estimates obtained by the proposed Markov chain Monte Carlo methods are accurate and the Bayes factor computed via a path sampling procedure is useful for identifying the correct number of components, selecting an appropriate missingness mechanism, and investigating various effects of latent variables in the mixture SEMs. A real data set on a study of job satisfaction is used to demonstrate the methodology.