Biomagnetism from the neuropsychiatric viewpoint--principles of recent developments in diagnostic procedure

The following survey is intended to demonstrate and discuss some principle problems of biomagnetism and the application in clinical fields. The development of special technical parameters especially by the SQUID method is initiating new possibilities of research and completing the neurobiologically determinated basis and conditions of neuropsychiatric disorders. The Magnetoencephalography (MEG) will be represent an important role of a new functional diagnostic method.     

The effects of child abuse as seen in adults: George Orwell

The author presents the case of a patient who showed the massive defensive effects seen in people who were abused in childhood. These effects are similar to those described in George Orwell's 1984 and in his autobiographical writings: denial and "doublethink"; masochistic submission to the tormentor; turning of anger against the self and loving "Big Brother"; identifying with the abuser and tormenting others; a burgeoning of anal mechanisms and obsessive phenomena that results in a massive isolation of affects; excessive emotional control alongside outbursts of rage. The interference with memory and emotions compromises identity and humanity. The unforseeable evolution of innate gifts in a child sometimes permits a partial transcendence of these crippling defenses, as Orwell partially transcended what appears to have been the emotional deprivation of his childhood and what he felt to have been the abuse of his schoolboy years.     

Electrophysiological correlates of semantic features

Analyses of averaged auditory evoked responses to a list of 10 positive and 10 negative words led to the identification of a restricted region in the brain response which reliably discriminated between words differing in the semantic features positive and negative. These data support the view that word meanings are composed of more basic components or features and are not stored simply as dictionary items in the brain.     

Nonprofessional counselors: Revisiting selection and impact issues

This study examined two issues related to the use of nonprofessional counselors (n = 159) within the context of a diversion program for juvenile offenders. First, the relationship of the nonprofessionals' personality traits and general attitudes to client outcome was examined. No statistically significant correlations were observed. Second, the differential impact of various training and supervision factors was examined in terms of nonprofessional satisfaction, attitudes, and locus of control. Results suggested that training intensity, training content, and supervision setting may influence nonprofessionals' attitudes towards various social groups and their satisfaction with the nonprofessional experience.     

Adaptation and vulnerability in high-risk adolescents: An examination of environmental mediators

The relationship of characteristics of the social environment to the adaptation of adolescents from high-risk predisposing environments was examined. Specifically, the degree to which adolescents' perceptions of various dimensions of their family and school environment as well as sources of social support related to differential levels of personal well-being and academic adjustment was explored. Multiple regression analyses revealed differences in the salience of the dimensions of the social environment as a function of the particular sphere of functioning under consideration. Implications of the findings for developing a model for understanding the relative vulnerability of individuals at risk as well as of the design of preventive interventions are discussed.     

Analytic,synthetic, abstracting,and word-class-defining aspects of verbal mother-child interactions

Phenomena of language teaching and learning in the course of verbal interactions between one mother and her daughter were analyzed. The daughter was between 18 and 27 months old during the recordings, and her utterance length ranged from 1,5 to 4,0 morphemes. Twenty hours of interactions were analyzed and the emphasis was placed upon sequential aspects and mathemagenic features of the conversations. It was demonstrated that the mother performs much analytic, synthetic, abstracting, and word-class-defining work during these verbal interactions. These maternal instructional activities seem to lead not only to the child's learning of language rules but also to her employment of the abstracting, analytical, and synthetic methodology. It is concluded that the main explanatory focus has to be on the mother in the attempts to explain language transmission and acquisition. Basic similarities to other instructional/skill training situations are suggested. Neither extraordinary complex cognitive nor innate linguistic capacities need to be assumed to explain the phenomena in question.     

Recent stressful life events and young children's school adjustment

A group of 211 first-to fourth-grade children who had experienced one or more recent stressful life events were compared to a demographically matched sample of 211 children who had not experienced such events on measures of school adjustment problems and competencies. Stressful life events were found to be associated with the presence of more serious school adjustment problems and fewer competencies. Those associations were strongest for children who had experienced multiple recent stressful events. The importance of preventive interventions for this at-risk group was emphasized and future research steps in the area were considered.     

Selective association in conditioned stress-induced analgesia: functional differences in interoceptive and exteroceptive sensory pathways

Rats were used to determine whether stress-induced analgesia (SIA) can be produced by conditioning with interoceptive stimuli (LiCl) as with exteroceptive stimuli (footshock). SIA was measured using a tail-flick test. As expected, unavoidable footshock as well as conditioning with footshock produced SIA. In contrast, conditioning with LiCl failed to cause SIA. The findings support the notion of functional differences in neural substrates for conditioning by exteroceptive and interoceptive cue.     

Differential ethanol olfactory experiences affect ethanol ingestion in preweanlings but not in older rats

Preweanling (21 days old) and adult (60-80 days old) rats were exposed to ethanol odor either paired with the early stages of apomorphine-induced toxicosis, paired with the recovery from toxicosis, or unpaired with the induction of distress. Twenty four hours later, ethanol preferences were measured in a spatial olfactory test (ethanol vs lemon odor) or a drinking test (5.6% v/v ethanol vs 0.25% w/v citric acid solutions). During the olfactory test both young and adult rats expressed substantial ethanol odor aversions when previously exposed to this odor paired with toxicosis. However, changes in ethanol intake became apparent only in preweanling subjects. Preweanlings which received the ethanol odor paired with illness drank significantly less of the ethanol solution relative to controls, while subjects experiencing the odor paired with recovery from distress significantly increased their consumption of the ethanol solution. These prior aversive and appetitive olfactory experiences had no effect upon ethanol intake in adult rats. These results implicate both an ontogenetic and a sensorial factor in the regulation of ethanol intake.     

Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 micrograms/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.