艰难梭菌感染：ICU中如何处理

艰难梭菌相关性腹泻（CDAD）是重症患者非常重要的院内感染性疾病之一,常与广谱抗菌药物的广泛应用有关,其中肠道菌群失调是重要的因素之一。虽然艰难梭菌感染（CDI）仅占抗菌药物相关性腹泻中的10％～20％,但是目前CDAD的发生率呈明显升高趋势,且根据研究显示,重症患者CDAD的30天病死率已达36．7％。CDAD的临床...     

替格瑞洛与氯吡格雷对急性STEMI患者急诊PCI术后炎症因子的影响

为比较替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死（STEMI）患者急诊经皮冠状动脉介入术（PCI）术后炎症因子的影响,将176例急性STEMI且行急诊PCI术的患者分为替格瑞洛组（A组）58例、氯吡格雷常规组（B组）58例、氯吡格雷强化组（C组）60例,分别测定术前、术后12小时、术后7天、术后1个月、术后3个月、6个月时炎症因子e反应蛋白（CRP）、白细胞介素-6（IL6）、髓过氧物酶（MPO）、可溶性CD40受体（sCD40L）的含量,比较3组患者各炎症因子在不同时间点有无统计学差异。结果显示c组和A组较B组明显降低（P〈0．05）,有统计学意义,而A组较c组稍降低（P〉0．05）,但两者无统计学意义。由此可见,替格瑞洛的抗炎作用较常规剂量氯吡格雷作用明显增强,和强化剂量氯吡格雷作用相仿。     

To be a Fan is to be Happier: Using the Eudaimonic Spectator Questionnaire to Measure Eudaimonic Motivations in Spanish Fans

Many studies have linked audiovisual entertainment to hedonia. Recently, also to eudaimonic happiness. The Eudaimonic Spectator Questionnaire is proposed as a new tool to explore eudaimonic motivations that are linked to the consumption of audiovisual entertainment. The new questionnaire groups these eudaimonic motivations into two factors: the cultivation of cognitive–intellectual growth and social–emotional growth. Once the consistency and reliability of the questionnaire was tested, we observed statistically significant differences between fans and non-fan spectators; these differences were observed in both factors. The results indicated that being a fan is associated with the cultivation of human virtues and character strengths.     

同事个性化契约对员工工作退缩行为的影响:基于公平理论的视角

个性化契约作为组织中一种非标准化的工作安排,以往研究较多关注其对契约获得者的积极效应,相对忽视了对未获得者的消极影响。鉴于此,本研究基于公平理论,探讨了同事个性化契约对员工工作退缩行为的影响及其内部机理。结果发现:同事个性化契约会引发员工的工作退缩行为,员工的心理契约违背在此过程中起部分中介作用;此外,员工与组织间较高的社会交换关系会削弱同事个性化契约对员工心理契约违背的正向影响。     

Action‐semantic and syntactic deficits in subjects at risk for Huntington's disease

Frontostriatal networks play critical roles in grounding action semantics and syntactic skills. Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (HD) and Parkinson's disease, even during early disease stages. However, frontostriatal degeneration in these conditions may begin up to 15 years before the onset of clinical symptoms, opening avenues for pre‐clinical detection via sensitive tasks. Such a mission is particularly critical in HD, given that patients’ children have 50% chances of inheriting the disease. Against this background, we assessed whether deficits in the above‐mentioned domains emerge in subjects at risk to develop HD. We administered tasks tapping action semantics, object semantics, and two forms of syntactic processing to 18 patients with HD, 19 asymptomatic first‐degree relatives, and sociodemographically matched controls for each group. The patients evinced significant deficits in all tasks, but only those in the two target domains were independent of overall cognitive state. More crucially, relative to controls, the asymptomatic relatives were selectively impaired in action semantics and in the more complex syntactic task, with both patterns emerging irrespective of the subjects’ overall cognitive state. Our findings highlight the relevance of these dysfunctions as potential prodromal biomarkers of HD. Moreover, they offer theoretical insights into the differential contributions of frontostriatal hubs to both domains while paving the way for innovations in diagnostic procedures.     

Personality Disorders Are Not as We Thought: Hierarchical Factor Structure at the Criterion Level

The use of personality disorder (PD) categories persists, despite the evidence against them. An often overlooked reason for this is the fact that the true structure underlying the Diagnostic and Statistical Manual of Mental Disorders (DSM) taxonomy is still unknown: We cannot be certain which disorders are valid, and which ones are arbitrary mixtures of heterogeneous traits. To address this gap, we factor analyzed the Personality Diagnostic Questionnaire (PDQ–4+; Hyler, 1994 Hyler, S. E. (1994). PDQ–4+ Personality Diagnostic Questionnaire–4+. New York, NY: New York State Psychiatric Institute. [Google Scholar]) at the criterion level in a mixed clinical and nonclinical sample of 2,519 individuals. The resulting structure was more similar to current dimensional taxonomies than to the DSM classification at all hierarchical levels. Whereas paranoid and antisocial PDs—and to a lesser extent avoidant, dependent, depressive, and schizoid PDs—were fairly homogeneous, all other disorders turned out to be combinations of 2 or 3 unrelated dimensions. Our results strongly support the structure of empirically based dimensional taxonomies and relocate DSM criteria within this emerging framework, thus contributing to preserving much of the knowledge accumulated to date.     

教师支持与心理素质对中学生学业成绩的影响

采用学生感知教师支持行为问卷和中学生心理素质问卷,对西南地区两所中学7~12年级的824名在校中学生进行调查研究,探讨教师整体支持和不同类型支持与中学生学业成绩的关系及心理素质在其中的中介作用。结果发现：（1）教师整体支持与中学生心理素质、学业成绩间存在显著正相关;教师情感支持与中学生心理素质、学业成绩间存在显著正相关,教师学习支持、能力支持与中学生心理素质存在显著正相关,但与学业成绩相关均不显著;（2）控制性别和年龄后,心理素质在教师整体支持与学业成绩的关系中起完全中介作用;心理素质在教师情感支持与学业成绩关系中起部分中介作用,在教师学习支持与学业成绩、教师能力支持与学业成绩关系中均起完全中介作用。     

反应抑制的训练:内容、效果与机制

近期的研究发现,个体的反应抑制能力具有一定的可塑性。研究者多采用双盲随机对照实验设计,训练的对象包括儿童、成人和特殊群体,研究者通过Go/Nogo、Stop-signal等任务进行为期1周至3周,45至7200试次不等的抑制控制能力训练,并结合行为、脑电以及脑成像等技术对训练效果进行评估,研究结果发现,接受了抑制控制训练的个体其抑制能力得到提升,并伴随脑神经活动的变化。另外,研究者发现,抑制控制能力的训练效果还可以迁移至个体日常生活中的表现。但是,也有些研究并未发现抑制控制训练的效果。训练任务的设置,评估任务的选择以及被试反应策略的差异等因素可能会影响训练的效果。抑制控制训练引发行为与大脑活动的变化可能是由于训练导致了个体建立了自上而下有意识的抑制控制模式和自下而上的自动抑制模式。反应抑制和冲突抑制可塑性的比较,儿童与老年人抑制功能的训练以及训练效果的追踪研究将成为该领域日后研究的重点问题。     

熟悉性和兼容性对复合社会范畴刻板印象表征的影响

通过对启动任务范式的改进,运用3个实验全面考察了复合社会范畴本身的熟悉性和兼容性对复合社会范畴刻板印象中抽象表征和样例表征策略运用的影响。实验1分别以熟悉的、不熟悉且在刻板印象上不兼容的复合范畴为研究对象,研究发现对熟悉的复合范畴采用抽象表征,而对不熟悉且在刻板印象上不兼容的复合范畴的表征采用样例表征;实验2以熟悉且在刻板印象上不兼容的复合范畴为研究对象,研究发现对于熟悉但构成范畴不兼容的复合范畴的表征也采用样例表征;实验3采用相同的实验范式,在描述和定义两种启动任务中设置子范畴间兼容的刻板特质词和不兼容的刻板特质词,选择与实验2相同的复合范畴"男中学教师"为目标群体,更加严密地证实和整合了实验1与实验2的研究结论。3个实验的结果说明复合范畴刻板印象的表征关键取决于兼容性,一旦复合社会范畴的构成范畴在刻板印象上不兼容,那么对于这一复合社会范畴刻板印象的表征采用样例表征。当构成复合范畴的两个子范畴之间兼容时,熟悉性成为刻板印象运用抽象表征还是样例表征的影响因素,无论是对内群体的刻板印象还是外群体的刻板印象,对熟悉的刻板特质词的表征运用抽象表征。     

全球生命伦理学

探讨生命伦理学的起源,并阐述了不同理论支持者的观点,发现无论准确的生命伦理学历史起源是什么,目前生命伦理学已经变成了一种真正的全球现象。它在全世界具有重要的意义,因为人类不仅仅是欧洲人或亚洲人,也是世界公民和一个全球道德共同体的成员。生命伦理学对任何地方、任何人都是重要的,并不是因为它是"拿来"的,而是因为它提供了一个普遍的框架去解释和管理正在经历的变化,这个变化包括了目前所有的国家和文化。然而,这个框架的解释和应用必须依据本土环境。因此,现代生命伦理学具有全球性和本土特征的特点。