Purple sweet potato color repairs d-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins

Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins used to color food (E163), has been reported to possess a variety of biological activities, including anti-oxidant, anti-tumor, and anti-inflammatory. The effect of PSPC on the spatial learning and memory of mice treated with d-galactose (d-gal) was evaluated by the Morris water maze; d-gal-treated mice had decreased performance compared with mice in the vehicle and PSPC groups, while the PSPC + d-gal group showed significantly shortened escape latency to platform, increased swimming speed, more target quadrant search time and more platform crossings as compared with the d-gal group. Brain functions, such as memory formation and recovery of function after injury, depend on proper regulation of the expression levels of the pre- and post-synaptic proteins. We investigated the expression of four pre-synaptic proteins (growth-associated protein-43, synapsin-I, synaptophysin, and synaptotagmin) and two post-synaptic proteins (post-synaptic density protein-95 and Ca²⁺/calmodulin-dependent protein kinase II) in the hippocampus and cerebral cortex, respectively, in response to different treatments. Western blotting analysis showed that there were significant decreases in the expression of these representative synaptic proteins in the hippocampus and cerebral cortex of d-gal-treated mice. Interestingly, these decreased expression levels of synaptic proteins could be reversed by PSPC. The levels of expression of these representative synaptic proteins in mice treated with PSPC alone were not significantly different from those in untreated mice. The results of this study suggested that memory impairment and synaptic protein loss in d-gal-treated mice may be improved by treatment with PSPC.     

核心价值体系与国家之前途和命运

核心价值体系是国家意识形态的核心内容.核心价值体系是国家经济社会发展、政治变革的价值动力;也是国家之间意识形态竞争的主要内容.核心价值体系决定着国家的前途和命运,建设与国家前途、世界命运相适应的核心价值体系意义重大.     

存在主义心理治疗及其儒学解读

受存在主义心理治疗理论的启发,阐述了其理论在以儒学为基础的传统文化下的解读,强调儒家的为己修身之学从家庭的领域扩散出去,通过人伦教化的落实对主体自觉性的激发,形成对自我心性的超越.这一过程正是对本体存在意义的诠释与实践,也使存在主义的治疗理论落实到日常的修身实践当中.     

几种常用非补偿型认知诊断模型的比较与选用：基于属性层级关系的考量

当前国际上开发了60多种认知诊断计量模型(Fu &; Li, 2007), 各种模型各具特点, 实际应用者应根据实际情况选用恰当的模型。本研究以属性层级关系为切入点, 采用Monte Carlo模拟的研究方法, 比较了属性层级关系正确及有误两种情况下, 当前国际上常用的五种认知诊断模型的性能, 以充分考察不同认知诊断模型对属性层级关系的依赖程度, 及属性层级关系的错误界定对各认知诊断模型诊断正确率的影响, 从而为实际运用者在认知诊断模型选用上提供借鉴和参考。     

新生儿疾病的共同决策框架和工具应用进展

以新生儿疾病为重点,介绍了医患共同决策的定义和发展历史,以及在新生儿疾病治疗中实现共同决策的一些工具,其中包括共同决策框架与模型以及决策辅助工具,共同决策框架以临床咨询、决策辅助和指导等形式为新生儿家属提供决策支持,决策辅助工具则借助宣传册、视频和交互式网站等形式,帮助医患共同决策,减少其决策冲突,提高决策质量和满意度。最后探讨了新生儿疾病治疗中实施共同决策的挑战,以及未来研究将要前进的方向,为促进医患共同决策在新生儿学科的发展提供新的思路。

     

家庭治疗在我国临床实践中的应用

家庭治疗作为心理治疗领域的"第四势力",将个体置于关系之中去考察其心理问题,通过改变家庭成员围绕症状所表现出来的交往方式,从而达到治疗症状的治疗方法.该疗法的研究与实践很快渗透到心身疾病,成瘾、抑郁、强迫、精神分裂症等许多领域,在临床实践中得到广泛的使用并取得了较好的效果.     

汉语声调远距离规则的内隐学习及其迁移效应

内隐学习研究领域的一个重要问题是内隐学习获得的知识究竟是什么,即内隐学习获得的知识究竟是底层的抽象规则还是表面的特征.研究以汉语声调的远距离水平映射这一远距离规则为材料,通过对表面特征和底层规则之间的分离操作,在控制组块和重复结构等表面特征的条件下,探讨声调远距离规则的习得和迁移,结果发现被试能够内隐地习得和迁移汉语平仄声调的水平映射规则,证实了内隐学习确实能够获得底层的抽象规则,为内隐学习的抽象性问题提供了新的证据.     

信任倾向和面孔可信度对小学儿童信任判断的影响

该研究考察了7、9、11岁小学儿童对陌生人信任判断的发展特点,以及信任方的信任倾向和被信任方的面孔可信度在儿童信任判断中的作用特点及其发展特征。结果发现：（1）7、9、11岁小学儿童基于面孔对陌生他人进行的信任判断中,9、11岁儿童的信任水平要高于7岁儿童;（2）在信任判断中,陌生交往者的面孔可信度对7、9和11岁儿童的信任判断都具有显著的影响作用,即相对于具有不可信面孔的陌生人,儿童更愿意相信具有可信面孔的陌生人;此外,信任倾向对于信任判断的影响作用则存在一定的年龄间差异,7岁儿童的信任倾向对信任判断无影响,9和11岁儿童的信任倾向正向预测儿童对陌生人的信任水平,即相对于信任倾向低的儿童,信任倾向高的儿童对陌生人的信任水平也越高;（3）被信任方的面孔可信度在小学儿童信任判断中的影响作用要大于儿童自身的信任倾向的影响作用。这些结果表明儿童对他人的信任水平随着年龄的增长而提高;对于陌生人,小学儿童主要依据被信任方相关的可信特征线索做出相应的信任判断。     

情绪对注意功能网络的调制

情绪性注意是一种对具有情绪意义的刺激进行选择和加工的注意.由于刺激的情绪效价能调制人脑的感知和注意系统,因而,与对中性刺激的注意相比,情绪性注意的神经机制更加复杂.较早的研究显示,杏仁核对感知皮层的调制对情绪性注意起关键作用.近期的证据表明,杏仁核对注意功能网络的调制可能是其重要的神经机制.本文梳理了相关领域的研究证据,主要强调情绪性刺激对注意的警觉、定向和执行控制网络的调制,发现情绪性注意加工的认知神经机制可能涉及一个以杏仁核为核心的多重功能网络.     

Response Inhibition and ADHD Traits: Correlates and Heritability in a Community Sample

Endophenotypes or intermediate phenotypes are of great interest in neuropsychiatric genetics because of their potential for facilitating gene discovery. We evaluated response inhibition, latency and variability measures derived from the stop task as endophenotypes of ADHD by testing whether they were related to ADHD traits in the general population, heritable and shared genetic risk with ADHD traits. Participants were 16,099 children and adolescents, ages 6 to 18 years who visited a local science center. We measured ADHD traits using the Strengths and Weaknesses of ADHD-symptoms and Normal-Behavior (SWAN) rating scale and performance on the stop signal task (SST)—response inhibition (SSRT), response latency (GoRT), and response variability (GoRTSD). Regression analysis was used to assess the relationship of cognitive measures and ADHD traits while controlling for family, age, sex, ethnicity, socioeconomic status and treatment status. Heritability of ADHD and cognitive traits was estimated using SOLAR in 7,483 siblings from 3,507 families that included multiple siblings. Bivariate relationships between pairs of variables were examined. Individuals with greater ADHD trait scores had worse response inhibition, slower response latency, and greater variability. Younger participants and girls had inferior performance although the gender effects were minimal and evident in youngest participants. Inhibition, latency, variability, total ADHD traits, inattention and hyperactivity-impulsivity scores were significantly heritable. ADHD traits and inhibition, but not latency or variability were coheritable. In the largest study in the general population, we found support for the validity of response inhibition as an endophenotype of ADHD.