Spatial and visual learning deficits in Alzheimer's and Parkinson's disease

Experimental paradigms adopted from animal models were used to compare the neuropsychological mechanisms underlying the dementias of Alzheimer's and Parkinson's diseases. Two tasks were selected because characteristic profiles of impairment in nonhuman primates are seen following selective lesions of frontal cortex, temporal cortex, and fornix. The tasks consisted of a spatial and a visual learning problem, each with two components: (1) original learning and (2) reversal of the original learning. The Alzheimer's patients were significantly impaired on original learning and reversal learning in the visual modality compared with demented Parkinson's patients, even though both groups were equated for severity of dementia. On the spatial tasks, both the Alzheimer's and the demented Parkinson's patients were impaired on reversal learning but not on original learning. The profile of deficits on the visual tasks may serve to differentiate Alzheimer's from Parkinson's dementia and may reflect selective orbitofrontal system lesions in the former.     

On the development of procedural knowledge

Amnesic patients demonstrate by their performance on a serial reaction time task that they learned a repeating spatial sequence despite their lack of awareness of the repetition (Nissen & Bullemer, 1987). In the experiments reported here, we investigated this form of procedural learning in normal subjects. A subgroup of subjects showed substantial procedural learning of the sequence in the absence of explicit declarative knowledge of it. Their ability to generate the sequence was effectively at chance and showed no savings in learning. Additional amounts of training increased both procedural and declarative knowledge of the sequence. Development of knowledge in one system seems not to depend on knowledge in the other. Procedural learning in this situation is neither solely perceptual nor solely motor. The learning shows minimal transfer to a situation employing the same motor sequence.     

A componential model for mental addition

A componential model capable of representing simple and complex forms of mental addition was proposed and then tested by using chronometric techniques. A sample of 23 undergraduate students responded to 800 addition problems in a true-false reaction time paradigm. The 800 problems comprised 200 problems of each of four types: two single-digit addends, one single- and one double-digit addend, two double-digit addends, and three single-digit addends. The results revealed that the columnwise product of addends, a structural variable consistent with a memory network retrieval process, was the best predictor of mental addition for each of the four types of problem. Importantly, the componential model allowed estimation of effects of several other structural variables, e.g., carrying to the next column and speed of encoding of digits. High levels of explained variance verified the power of the model to represent the reaction time data, and the stability of estimates across types of problem implied consistent component use by subjects. Implications for research on mental addition are discussed.     

Parts of visual objects: an experimental test of the minima rule

Three experiments were conducted to test Hoffman and Richards's (1984) hypothesis that, for purposes of visual recognition, the human visual system divides three-dimensional shapes into parts at negative minima of curvature. In the first two experiments, subjects observed a simulated object (surface of revolution) rotating about a vertical axis, followed by a display of four alternative parts. They were asked to select a part that was from the object. Two of the four parts were divided at negative minima of curvature and two at positive maxima. When both a minima part and a maxima part from the object were presented on each trial (experiment 1), most of the correct responses were minima parts (101 versus 55). When only one part from the object--either a minima part or a maxima part--was shown on each trial (experiment 2), accuracy on trials with correct minima parts and correct maxima parts did not differ significantly. However, some subjects indicated that they reversed figure and ground, thereby changing maxima parts into minima parts. In experiment 3, subjects marked apparent part boundaries. 81% of these marks indicated minima parts, 10% of the marks indicated maxima parts, and 9% of the marks were at other positions. These results provide converging evidence, from two different methods, which supports Hoffman and Richard's minima rule.     

Lesbian Partner Abuse: Implications for Therapists

Silence surrounds the issue of lesbian battering. Lesbian victims of partner abuse are even less likely than are their heterosexual counterparts to seek help in shelters or from counselors because of the overlay of homophobia that exists both in the battered women's movement and among mental health professionals. In addition, many lesbian and many lesbian-supportive therapists hold an idealized and unrealistic picture of the nature of lesbian relationships, leading them to deny the existence of buttering among lesbian couples. The nature, severity, and prevalence of abuse in lesbian relationships is addressed; current counseling and treatment models dealing with battering relationships are analyzed; and a counselor advocacy model for working with lesbian partner abuse, drawing from the experience of activists in the battered women's movement and our clinical experience, is suggested.     

Age deficits in recall under optimal study conditions

Young and older adults studied lists of words under both standard and optimal study conditions for subsequent free recall. Under optimal conditions, the participants studied each word for as long as they wished, were allowed to take notes, and were encouraged to actively use whatever strategies they thought would maximize recall. Both age groups recalled more words under optimal study conditions than under standard conditions, but the improvement was greater for the young adults. This increase in the age-related recall deficit was not due to differences in study time. The results suggest that standard laboratory memory tasks do not overestimate the memory deficits of older adults because of a failure to provide either optimal learning conditions or sufficient study time.     

Relationship of severity of dementia to caregiving stressors

In studies of individual differences and longitudinal changes in stress and coping among dementia caregivers, assessing severity of patient impairment is critically important. It is proposed that with the progression of dementia, cognitive impairment may steadily increase, but other stressful behavioral symptoms peak at various stages of dementia. Cross-sectional data from 49 caregiving families and longitudinal follow-up data from 48 families suggest that instrumental self-care deficits begin early in dementia, and basic self-care deficits increase with dementia severity, but that many distressing behavioral symptoms decrease in late dementia. Assessments of dementia patient severity should be multidimensional, and increases and decreases in various dementia patient stressors over time should be considered as factors influencing caregiver coping.     

Forecasting the impact of the federal sentencing guidelines

The Sentencing Reform Act of 1984, which created the U.S. Sentencing Commission, required that the commisson consider prison capacity in drafting sentencing guidelines. As part of the commission's efforts to meet this requirement, we developed a computer simulation capable of projecting the impact of the commission's guidelines on future sentences and prison populations. According to our projections, “straight” probation sentences will be reduced significantly under the guidelines. However, reducing the use of probation will generate only modest demands on the prisons, and then mostly for community corrections phased in over the course of 5 years. We also project that, while average time served for violent offenses will increase substantially, average time served for most property crimes will remain largely the same. Finally, while we forecast that federal prison populations will grow markedly by the end of this century, this is more a result of the Anti-Drug Abuse Act of 1986 and the career offender provision of the Comprehensive Crime Control Act of 1984 than a result of the guidelines.