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901.
Disturbances in exploratory behavior and functional recovery in the Y and radial mazes following dopamine depletion of the lateral septum 总被引:1,自引:0,他引:1
The effects of 6-hydroxydopamine (6-OHDA) injected into the lateral septum in rats were investigated for spontaneous alternation behavior in a Y maze and for spatially oriented behavior in an 8-arm radial maze. The performance of the animals in these tests was assessed under two physiological states, food-satiated and food-deprived. The selective depletion of septal dopaminergic concentrations leads to behavioral disturbances in both the Y and the radial mazes. These deficits disappeared when the animals with 6-OHDA lesions were food-deprived. These results confirm other studies from our laboratory and support two conclusions. First, lesions of dopaminergic neurons lead to behavioral impairments which resemble those found after the total lesion of the structure they innervate. Second, these behavioral impairments are responsive to therapeutic treatments, manipulations of the internal or external environment, or the level of arousal, since under certain conditions a recovery of function can occur in the absence of dopaminergic neurons. These two points provide additional support for a nonspecific role for the dopaminergic neurons originating in the ventral tegmental area. These neurons could have a permissive role in the functioning of the forebrain structures they innervate. 相似文献
902.
Substance P facilitation of memory: effects in an appetitively motivated learning task 总被引:1,自引:0,他引:1
K Schlesinger M A Pelleymounter J van de Kamp D L Bader J M Stewart T N Chase 《Behavioral and neural biology》1986,45(2):230-239
Food deprived, heterogeneous strain (HS/IBG) mice were trained on two different discrimination tasks for food reinforcement. In one experiment animals were trained to make spatial discriminations in a T maze. Immediately after training they were given subcutaneous injections of either substance P (1 ng/g) or vehicle. Twenty-four hours later the animals were given reversal training in the same maze. The results showed that substance P-treated animals took significantly longer to acquire the reversal habit than did control mice. In a second experiment, animals were trained to make visual discriminations in a T maze. Immediately after reaching acquisition criterion animals were injected with either substance P (1 ng/g) or vehicle. Different groups of mice were retrained on the same task either 1, 2, 3, or 7 days after original learning. Savings scores were calculated and, at every interval, substance P-treated mice retained the task better than control animals. One interpretation of these data is that substance P-treated mice remembered the original task significantly better than vehicle-injected control animals. 相似文献
903.
C F Flaherty G A Rowan 《Journal of experimental psychology. Animal behavior processes》1986,12(4):381-393
Contrast effects were obtained in rats in the consumption of saccharin solutions in three different paradigms. Degree of negative contrast varied as a function of concentration disparity, but not equally in the three procedures. Successive negative contrast occurred following shifts from 0.15% to either 0.075% or 0.05% saccharin but did not occur following shifts to 0.10% or 0.125% saccharin. Some degree of simultaneous contrast was obtained with all four concentration disparities. Anticipatory contrast, where the intake of the first substance is suppressed by a more preferred second substance, occurred only in the case of the 0.05%-0.15% difference in concentrations. It was suggested that the several contrast paradigms engage somewhat different psychological processes differentially involving emotional, sensory, and associative mechanisms, but all lead to behavior based on relative value. A modification of Toates's (1981) incentive model of ingestive behavior was suggested to incorporate relativity effects based on both associative and nonassociative factors in the consumption of both nutritive and nonnutritive substances. 相似文献
904.
Initial environment influences amphetamine-induced stereotypy: subsequently environment change has little effect 总被引:1,自引:0,他引:1
Saline-treated and amphetamine-treated (7 mg/kg, ip, immediate) male rats from a Sprague-Dawley substrain were observed in two test environments designed to elicit different investigative responses in normal rats. Snout contact with the substrate was generated by placing the rat in a small enclosed cage. Absence of snout contact was induced by placement of the rat on a square elevated platform. Detailed ethological records were kept of locomotion, rearing, sitting, grooming, gnawing, and sleeping throughout the 90-min session. Amphetamine-treated rats incorporated environmentally contingent bodily postures into their forms of stereotyped behavior. The postures were characteristic of those evinced initially by the saline-treated rats in the same test environment. The control rats showed appropriate changes in their investigative behavior when the apparatus was changed at 10 and at 30 min postinjection. The amphetamine-treated rats, however, were completely unresponsive to such changes at 30 min and only partially so at 10 min postinjection. It was concluded that there is a temporal gradient of decreasing readiness to modify repetitive behavior after a single, large dose of amphetamine. 相似文献
905.
Sixty fourth-grade children were given two different series of the Porteus Maze Test. The first series was given as a baseline, and the second series was administered under one of four different experimental conditions: control, response cost, positive reinforcement, or negative verbal feedback. Response cost and positive reinforcement, but not negative verbal feedback, led to significant decreases in the number of all types of qualitative errors in relation to the control group. The reduction of nontargeted as well as targeted errors provides evidence for the generalized effects of response cost and positive reinforcement. 相似文献
906.
In an exploration of the social impacts of treatments for hyperactivity, two age groups (kindergarteners and first-graders vs. fourth- and fifth-graders) heard about a hyperactive child whose problem was treated either by an internal and controllable means (effort) or by an external and uncontrollable means (medication) and whose behavior either did or did not improve. The attributions and affective responses of both age groups were influenced by both the nature and the effectiveness of treatment, and there was only weak support for the hypothesis that younger children are more influenced by treatment outcome than older children are. However, older children, conforming to attribution theory predictions, held target children more accountabe for the success or failure of their own efforts than for the outcomes of medication, particularly valuing the child whose own efforts succeeded. By contrast, young children judged the child whose efforts failed as more worthy of pride and more likable than the child whose medication failed. Implications for peer acceptance of hyperactive children over the childhood years are discussed.Portions of this paper were presented at the annual meeting of the Southeastern Psychological Association, Atlanta, March 1985. Thanks are extended to the staff and students of the Model Laboratory School. 相似文献
907.
Peter C. Fishburn 《Synthese》1986,67(2):361-368
Axiomatizations of ordered preference differences typically assume that preferences are ordered. However, the mere assumption that preference differences can be ordered says nothing about whether preferences themselves are ordered. Utility representations for ordered differences without ordered preferences are investigated. 相似文献
908.
A common technique in research into cerebral asymmetry in both normal and clinical populations involves the use of lateralized visual displays. The validity of this approach depends on several generally implicit assumptions about the character of the cognitive processes involved. For example, when words are used as stimuli, cognitive processing is assumed to involve either "whole-word" or "ends-in" analysis. In this way, both hemispheres are assumed to have equal opportunities to recognize the word. These assumptions are critical, because if they are wrong, explanations based on established perceptual principles may provide a sufficient and more parsimonious explanation for hemifield asymmetries than hemispheric specialization theories. This point is developed and illustrated with particular reference to word recognition and classification. From a purely perceptual viewpoint, the right visual field advantage observed in tasks using word stimuli is to be expected given the presence of systematic biases in favor of initial characters or features of words and the relationship between retinal eccentricity and visual acuity. In other words, there is no need nor justification for a hemispheric account of visual field differences in such tasks. Some of the limiting conditions and theoretical implications of this argument are identified and discussed. 相似文献
909.
Measures adapted from social survey research were used to assess the quality of life of 33 end-stage renal disease (ESRD) patients in a 2-week test-retest design that varied both location and format of administration (hospital interview vs. home self-administered questionnaire). The measures were found to have substantial consistency over time, location, and format. These results indicate that quality of life is a stable construct and support the usefulness of questionnaire quality-of-life measures for evaluating medical interventions. 相似文献
910.
Health as a value: methodological and theoretical considerations 总被引:8,自引:0,他引:8
The concept of value placed on health is very important in several different theoretical approaches to the study of health behavior. In practice, however, health value is generally assumed to be universally high rather than being directly measured. If this assumption is incorrect, then theories that include health value have rarely been adequately tested. This paper presents a short 4-item Likert scale designed to measure the value placed on health. Norms from the utilization of this scale in five different samples are presented. Health value is found to increase with age among girls, but the increase apparently stops by late adolescence, before full adult levels of health value are achieved. Middle-aged women place a higher value on health than do middle-aged men, although no comparable sex difference appears in a sample of undergraduates. Consistent with theoretical predictions, both health locus of control beliefs and beliefs in the efficacy of certain preventive health behaviors correlate more highly with the performance of those same behaviors 5 to 9 months later among respondents who place a high value of health relative to those who do not value health so highly. However, this interaction is found only when it can be safely assumed that health is the primary value underlying the behavior. The importance of considering a variety of values in addition to health as possible motivators of preventive health behavior is stressed. 相似文献