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941.
942.
Tolbutamide has previously been shown to amplify the pressor effects of “exogenous” catecholamines in conscious dogs, possibly due to sensitization of the α1-adrenoreceptor-mediated vasoconstriction. The objective of this study was to examine if tolbutamide also amplifies the pressor effects of “endogenous” catecholamines released during psychological stress (classical Pavlovian aversive conditioning). Experiments were conducted in β-adrenoreceptor-blocked (propranolol, 1 mg/kg, i.v.) conscious dogs (n=4) trained in classical aversive conditioning. Conditioning was accomplished by following a tone (CS+) with a 1/2 second shock; another tone (CS-) was not followed by any shock and served as control. With saline pretreatment, aversive conditioning (i.e., CS+) increased mean arterial pressure (MAP) only by approximately 4.7% when compared to CS-, whereas with tolbutamide (45 mg/kg, i.v.) pretreatment, the increase in MAP induced by CS+ beyond what was induced by the CS- (approximately 6.2%) was significantly (p<0.05) larger than that with saline pretreatment. In isolated canine femoral arterial segments (n=4), the vasoconstrictor effect of phenylephrine (an α1-agonist) at 5×10?6M (which was the EC50 value) was amplified by 2×10?2M of tolbutamide from 54.0±2.0% to 66.9±2.1%. In conclusion, tolbutamide amplifies the pressor effects of “endogenous” catecholamines in conscious dogs, possibly by sensitization of the α1-adrenoreceptor-mediated vasoconstriction. This mechanism of action is novel and has not been reported with other agents. 相似文献
943.
Sjoerd C. de Vries Astrid M. L. Kappers Jan J. Koenderink 《Attention, perception & psychophysics》1993,53(1):71-80
We used quadratic shapes in several psychophysical shape-from-stereo tasks. The shapes were elegantly represented in a 2-D parameter space by the scale-independentshape index and the scale-dependentcurvedness. Using random-dot stereograms to depict the surfaces, we found that the shape of hyperbolic surfaces is slightly more difficult to recognize than the shape of elliptic surfaces. We found that curvedness (and indirectly, scale) has little or no influence on shape recognition. 相似文献
944.
Christopher C. Pagano Paula Fitzpatrick M. T. Turvey 《Attention, perception & psychophysics》1993,54(1):43-54
Subjects wielded occluded rods, with or without attached masses, and reported the distances reachable with their distal tips. Experiments 1–3 compared wielding about the wrist, the elbow, and the shoulder. Experiments 4 and 5 compared free wielding, using the whole arm, with wielding only about the wrist. The two comparisons, respectively, were of spatial and temporal variations in the rod’s rotational inertia. Perceived extent was found to be constant in both comparisons. This constancy was tied to the inertia tensorI ij defined about a point that remains a fixed distance from the object during wielding—an invariant of the spatially and temporally dependent patterning of mechanical energy impressed upon the tissues of the body. Discussion focused on the reciprocal action and perception capabilities of multisegmented limbs, the tensorial relations in the neurobiology of dynamic touch, and the strategy of understanding perceptual constancy through invariants. 相似文献
945.
When an observer views a moving scene binocularly, both motion parallax and binocular disparity provide depth information. In Experiments lA-1C, we measured sensitivity to surface curvature when these depth cues were available either individually or simultaneously. When the depth cues yielded comparable sensitivity to surface curvature, we found that curvature detection was easier with the cues present simultaneously, rather than individually. For 2 of the 6 subjects, this effect was stronger when the component of frontal translation of the surface was vertical, rather than horizontal. No such anisotropy was found for the 4 other subjects. If a moving object is observed binocularly, the patterns of optic flow are different on the left and right retinae. We have suggested elsewhere (Cornilleau-Pérès & Droulez, in press) that this motion disparity might be used as avisual cue for the perception of a 3-D structure. Our model consisted in deriving binocular disparity from the left and right distributions of vertical velocities, rather than from luminous intensities, as has been done in classical studies on stereoscopic vision. The model led to some predictions concerning the detection of surface curvature from motion disparity in the presence or absence of intensity-based disparity (classically termedbinocular disparity). In a second set of experiments, we attempted to test these predictions, and we failed to validate our theoretical scheme from a physiological point of view. 相似文献
946.
Two visual half-field experiments tested Moscovitch’s (1979) proposition that cerebral asymmetry does not concern the earliest perceptual stages but only later processing. Subjects were briefly shown displays that included one (Experiment 1) or two (Experiment 2) types of forms differing in size and which, according to previous evidence, might lead to opposite laterality effects. Laterality effects were assessed for correct detections and for illusory conjunctions, both in terms of raw detection scores and in terms of perceptual discriminability (dr scores). In Experiment 1, displays included either rectangles or triangles. In the first case, the target was a cross; in the second case, it was a Star of David. A hemifield x size interaction was observed both on correct detections and on associated discriminability. Yet, no such interaction was obtained for illusory conjunctions or for associated d’ scores. In Experiment 2, the two types of forms were presented simultaneously, with the small ones either inside or outside the large ones. No laterality effects were observed. Some implications of these data for both hemispheric asymmetry and feature integration issues are discussed. The results suggest that early preattentive processes of feature extraction are not lateralized, whereas some integrative mechanisms, such as Treisman’s (1988) focal attention, may operate differently in the two hemispheres. 相似文献
947.
David C. Geary Pierre Cormier Judith P. Goggin Patricia Estrada Melanie C. E. Lunn 《International journal of psychology》1993,28(2):185-201
Two experiments compared rates of solving simple and complex addition and multiplication problems in groups of speakers of French or English in Experiment 1 (n = 35) and Spanish or English in Experiment 2 (n = 84). Subjects were divided into groups of English unilinguals, weak bilinguals, and strong bilinguals according to their performance on a naming task. In both experiments, simple problems consisted of two single-digit numbers. At least three single-digit numbers were used for complex problems in Experiment 1 and double-digit numbers in Experiment 2. Mean solution times, particularly for complex problems, were lowest for the monolingual group, followed in turn by the weak bilingual and strong bilingual groups, but these differences were not statistically reliable in either experiment. In Experiment 2, however, componential analyses of solution times indicated that strong bilingual subjects were slower at executing the carry operation when solving complex problems, relative to the two remaining groups. Results were interpreted in terms of the relationship between bilingualism and the representation and processing of numerical information. 相似文献
948.
LEON SLOMAN M.D. F.R.C.P.. STEPHEN SPRINGER Ph.D. C.Psych. MARY L.S. VACHON R.N. Ph.D. 《Family process》1993,32(2):171-183
When a deaf child is born to hearing parents, a grieving process is initiated in the parents. Unresolved grieving over their child's deafness often makes it difficult for hearing parents to accept the importance of signing, thus increasing the child's problems — further source of grief for these parents. Clinical illustrations are provided of (1) the reciprocal relationship between disruption of the mourning process and disturbance of communication between family members, and (2) the transmission of the dysfunctional relationship between hearing parents and deaf children to the subsequent relationship between the deaf children, when they reach adulthood, and their hearing children. 相似文献
949.
950.
We confirm Craik's (1947) observation that the human manual1y tracking a visual target behaves like an intermittent servo-control1er. Such tracking responses are indicative of "sampled" negative-feedback control but could be the result of other, continuous, mechanisms. Tracking performance therefore was recorded in a task in which visual feedback of the position of the hand-held joystick could be eliminated. Depriving the subjects of visual feedback led to smoother tracking and greatly reduced the signal power of their responses between 0.5-1.8 Hz. Their responses remained intermittent when they used feedback of their own position but not of the target to track a remembered (virtual) target. Hence, intermittency in tracking behavior is not exclusively a signature of visual feedback control but also may be a sign of feedback to memorized waveforms. Craik's (1947) suggestion that the intermittency is due to a refractory period following each movement was also tested. The errors measured at the start of each intermittent response, during tracking of slow waveforms, showed evidence of a small error deadzone (measuring 0.7 cm on the VDU screen or 0.80 degrees at the eye). At higher target speeds, however, the mean size of starting errors increased, and the upper boundary of the distribution of starting error was close to that expected of a refractory delay of approximately 170 ms between responses. We consider a model of the control system that can fit these results by incorporating an error deadzone within a feedback control loop. We therefore propose that the initiation of intermittent tracking responses may be limited by a positional error deadzone and that evidence for a refractory period between successive corrective movements can be satisfied without evoking an explicit timing or sampling mechanism. 相似文献