Differential ethanol olfactory experiences affect ethanol ingestion in preweanlings but not in older rats

Preweanling (21 days old) and adult (60-80 days old) rats were exposed to ethanol odor either paired with the early stages of apomorphine-induced toxicosis, paired with the recovery from toxicosis, or unpaired with the induction of distress. Twenty four hours later, ethanol preferences were measured in a spatial olfactory test (ethanol vs lemon odor) or a drinking test (5.6% v/v ethanol vs 0.25% w/v citric acid solutions). During the olfactory test both young and adult rats expressed substantial ethanol odor aversions when previously exposed to this odor paired with toxicosis. However, changes in ethanol intake became apparent only in preweanling subjects. Preweanlings which received the ethanol odor paired with illness drank significantly less of the ethanol solution relative to controls, while subjects experiencing the odor paired with recovery from distress significantly increased their consumption of the ethanol solution. These prior aversive and appetitive olfactory experiences had no effect upon ethanol intake in adult rats. These results implicate both an ontogenetic and a sensorial factor in the regulation of ethanol intake.     

Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 micrograms/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.     

Effects of social isolation in adulthood on odor preferences and urine-marking in male rats

Male rats isolated for 60 days in adulthood spent less time investigating odors of females and urine-marked less over these odors than did males kept in groups of three. Isolated males did not differ from grouped males in their responses to odors of unfamiliar males or their own odors. After social experience the isolated males showed an increase in urine-marking but no change in odor preferences. Individual housing therefore appears to alter olfactory communication in the same way that it does other social behaviors and these changes may be mediated by the same mechanisms.     

Neophobia in spontaneous hypertensive (SHR) and normotensive control (WKY) rats

Latency of approaching a novel object (white-colored cube) placed in an unfamiliar open field, duration of object exploration, ambulation, rearing, grooming, and defecation were investigated in spontaneous hypertensive rats (SHR), their genetic normotensive controls (WKY), and standard Laboratory rats of Wistar origin (Tif:RAIf). The parameters measured were taken as indices of fear due to novelty (neophobia). Remarkable differences in behavior of all three strains were observed. By comparison to RAIf and WKY rats, SHR showed decreased neophobia as reflected in the significantly shorter latency of approaching the object and enhanced ambulation and rearing activity in the open field. By comparison to RAIf rats SHR also showed reduced grooming and defecation. WKY rats distinguished themselves from both SHR and RAIf by almost total absence of all responses in this test situation. This behavioral suppression was antagonized by 7.5 mg/kg ip of chlordiazepoxide. The results of this study further support the notion that, by comparison to standard laboratory rats, both SHR and WKY rats show possible genetically determined, altered behaviors which are diametrically opposite to each other.     

Parent-infant resemblance for general and specific cognitive abilities in the Colorado adoption project

Previous publications emanating from the Colorado Adoption Project have reported significant relationships between parental general cognitive ability (g) and infant Bayley MDI scores. The present study compared infant Bayley factor scores representing separable dimensions of infant cognition with parental general and specific cognitive abilities for 182 adoptive families and 164 nonadoptive families. Parent/offspring correlations between 12-month Bayley factors and parental cognitive abilities suggest only minimal relationships for both parental g and specific abilities. At 24 months, more parent/offspring resemblance was present; moreover, Bayley factors that were related to parental cognition tended to be related to parental g, not to specific abilities. The finding of significant parent/offspring relationships at 24 months between biological parents and their adopted-away infants, as well as between nonadoptive parents and their infants, suggests some genetic continuity from infancy to adulthood.     

Conceptual,methodological, and clinical issues in cognitive-behavioral assessment

This article reviews cognitive-behavioral assessment principles and procedures. The functions of such assessments are noted, and issues and advances in cognitive assessment are discussed. The need for integrated cognitive, behavioral, and affective assessments is then explored. Finally, conceptual methodological, and clinical issues in the integration of assessments and study of reciprocal determinants are presented.Preparation of this paper was supported in part by a General Research Board Faculty Research Award from the University of Maryland. The author would like to thank Steve Graham, Donald Meichenbaum, Barbara Keogh, and Bernice Wong for their feedback during the preparation of this paper.     

Evidence for scanning with unilateral visual presentation of letters

When letters and words are presented tachistoscopically, material from the right visual field (RVF) can be reported more accurately than that from the left visual field (LVF). The RVF superiority may reflect either left hemispheric dominance for language or directional scanning. Previous studies have deliberately focused on the cerebral asymmetry factor while "controlling" scanning and, thus, have cast some doubt on the potency of the scanning factor. Two experiments were conducted to show that scanning can induce a RVF superiority comparable to that often associated with cerebral asymmetry. The first experiment required bilingual subjects to report six English or six Hebrew letters, shown briefly in either the LVF or RVF, with order of report controlled. A RVF superiority found with English characters was matched by an equal but opposite LVF effect with Hebrew. In a second experiment, five English characters were shown briefly in either the LVF or RVF, and subjects had to identify a single character indicated by a post exposural cue. Using a spatial cue to by pass scanning, there were no field differences; with an ordinal position cue--a procedure thought to force scanning--there was a strong RVF superiority. The results show clearly that scanning can induce visual field differences.