Clinical multiplicity of cerebrovascular disorders in childhood

A group of 107 children with vascular diseases of the nervous system aged 3-14 years have been studied. In 100 children of the study group acute disturbances of the brain blood circulation have been found, out of which 37 children were with transitory ischemic attacks; 29 were found to be with brain ischaemia; 22-with haemorrhages (7 cases with subarchnoidal, 9 cases with intracerebral and 6 cases with subarachnoidal-parenchimatose); 5 children had wenous thromboses; 7 children were with spinal strokes. In other 7 children we found the presence of Sturge-Weber syndrome. Congenital vascular malformations have been found in 32 children (30%), out of which 16 children (15%) with loops and stenosis of the extracranial segments of the internal carotid artery, and another 16 children (15%) with AV-malformations. Congenital and acquired heart diseases are found to be primary cause for the strokes in 12 children (11%). Considerable is the rate of the epileptic seizures in the acute stage of the strokes as well as of the residual epileptic syndromes.     

Information search following damage to the frontal lobes

Five adult patients with focal brain damage in different areas of the frontal lobes and five matched controls were administered a 20 Questions test. Other tests of planning, problem-solving, and decision-making were also administered to frontal lobe patients. The results indicate that damage to the frontal lobe impairs the ability to impose and utilize hierarchical organization in mental representation.     

The expected likelihood of transitivity of preference

May's model of pairwise preference determination is used to assess the expected likelihood that a subject's pairwise preference comparisons on three alternatives will be transitive. A closed form representation for this expected likelihood is obtained for each situation considered. When the subject is assumed to act precisely according to rankings on attributes with May's model, the computed expected likelihoods the relatively large. When the subject becomes a probabilistic chooser, as defined in a specific manner, expected likelihoods of transitivity decrease significantly from corresponding values with May's model. For a probabilistic Chooser, there is a significant likelihood that the subject might yield transitive pairwise preferences substantially different than the results suggested by May's model.This research was supported by a grant from the General University Research Program and through a fellowship from the Center for Advanced Study, both of the University of Delaware. Very helpful input from John H. Antil, Meryl P. Gardner, and James M. Munch is also acknowledged.     

Changes in information as a function of a culturally appropriate smoking cessation community intervention for Hispanics

Tested a 7-month, media-based, community intervention among Hispanics in San Francisco designed to change levels of information on the damaging effects of cigarette smoking and on the availability of culturally appropriate cessation services. Three community-wide surveys of Hispanics were conducted with independent random samples, two as baselines (n = 1,660 and 2,053) and one postintervention (n = 1,965). Results showed that changes in the level of awareness of cessation services had taken place after implementation of the intervention. Furthermore, those changes took place primarily among the less acculturated Spanish-speaking Hispanics who were the target of the intervention. The changes in information reported here demonstrate that a culturally appropriate information dissemination campaign that utilizes multiple channels can produce changes in a community's level of information even when the campaign is implemented for a relatively short period.     

On the relation between metacontrast masking and suppression of visible persistence

Does the introduction of additional contours in a display sequence (an operation known to reduce the strength of suppression in metacontrast) also reduce suppression of visible persistence? In three experiments, duration of visible persistence was estimated by a method in which successful performance depends on the temporal integration of a pattern whose elements are displayed in two successive frames. In this procedure, the arrival of the trailing frame is known to exert a suppressive influence on the visible persistence of the leading frame. Embedding the elements of the leading frame within additional contours (a line grid) reduced the degree of suppression exerted by the trailing frame. This did not occur when the grid was part of the trailing display. We conclude that suppression of visible persistence and metacontrast masking belong to the same class of events.     

Retraction of Ross and LoLordo findings concerning blocking in serial feature-positive discriminations.

Findings concerning the effectiveness of stimuli from various conditioning procedures in blocking conditioned excitation and occasion-setting functions of an added stimulus in a serial feature-postive discrimination training procedure (LoLordo & Ross, 1987; Ross & LoLordo, 1986, 1987) are retracted. Videotapes on which the published data were based were rescored by 2-5 people, most of whom were uninformed about group memberships of the subjects. In no case did the rescoring confirm any of the orginal findings of blocking. Possible factors contributing to the discrepancies are discussed. The experiments should be repeated with feature stimuli that are less similar to each other and with several scorers, at least one of whom is unaware of the group assignment of the subjects.     

Cholinergic-dopaminergic interactions in cognitive performance

Both acetylcholinergic (ACh) and dopaminergic (DA) systems have been found to be crucial for the maintenance of accurate cognitive performance. In a series of studies examining those aspects of cognitive function revealed by the radial-arm maze, we have found that these two neurotransmitter systems interact in a complex fashion. Choice accuracy deficits in the radial-arm maze can be induced by blockade of either muscarinic- or nicotinic-ACh receptors. The choice accuracy deficit induced by blockade of muscarinic receptors with scopolamine can be reversed by the DA receptor blocker, haloperidol. The specific DA D1 blocker SCH 23390 also has this effect, whereas the specific D2 blocker raclopride does not, implying that it is D1 blockade that is critical for reversing the scopolamine effect. On the other hand, the choice accuracy deficit induced by nicotinic blockade with mecamylamine is potentiated by haloperidol. This effect is also seen with the D2 antagonist raclopride, but not with the D1 antagonist SCH 23390, implying that it is the D2 receptor which is important for the potentiation of the mecamylamine effect. The relevance of the D2 receptor for nicotinic actions on cognitive function is emphasized by the finding that the selective D2 agonist LY 171555 reverses the choice accuracy deficit caused by mecamylamine. Nicotinic and muscarinic blockade are synergistic in the deficit they produce. Antagonist doses subthreshold when given alone produce a pronounced impairment when given together. This latter deficit can be reversed by the D2 agonist LY 171555. These studies have outlined the complex nature of ACh-DA interactions with regard to cognitive function. Possible neural circuits for these interactions are discussed. The effectiveness of these selective DA treatments in reversing cognitive deficits due to ACh underactivation suggests a novel approach to treating cognitive dysfunction in syndromes such as Alzheimer's disease.     

Transparency: relation to depth, subjective contours, luminance, and neon color spreading

The perception of transparency is highly dependent on luminance and perceived depth. An image region is seen as transparent if it is of intermediate luminance relative to adjacent image regions, and if it is perceived in front of another region and has a boundary which provides information that an object is visible through this region. Yet, transparency is not just the passive end-product of these required conditions. If perceived transparency is triggered, a number of seemingly more elemental perceptual primitives such as color, contour, and depth can be radically altered. Thus, with the perception of transparency, neon color spreading becomes apparent, depth changes, stereoscopic depth capture can be eliminated, and otherwise robust subjective contours can be abolished. In addition, we show that transparency is not coupled strongly to real-world chromatic constraints since combinations of luminance and color which would be unlikely to arise in real-world scenes still give rise to the perception of transparency. Rather than seeing transparency as a perceptual end-point, determined by seemingly more primitive processes, we interpret perceived transparency as much a 'cause', as an 'effect'. We speculate that the anatomical substrate for such mutual interaction may lie in cortical feed-forward connections which maintain modular segregation and cortical feedback connections which do not.     

Linear Analogue Self-Assessment and Procrustean Measurement: A Critical Review of Visual Analogue Scaling in Pain Assessment

Visual analogue scales (VASs) are one of the most widely used self-report measures of clinical pain. This article reviews the empirical literature on linear analogue self-assessment (LASA) and critically examines the features that appear to have made it such an attractive measurement option in pain assessment. It is concluded that analogue scaling does not withstand critical scrutiny as a primary measure of either pain intensity or pain affect and that, in most circumstances, the overall clinical utility of VASs is inferior to that of more structured pain indices.