Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Behavioral analysis of sexual dysfunction in Hansen's disease

Human sexual behavior is an interactive process including CNS, hormonal, and sex-gland activities. This process can be disrupted in males who have Hansen's disease if testicular atrophy occurs. Elevations of centrally mediated luteinizing hormone and deficient testosterone levels were found in a male with Hansen's disease whose insufficient erections were secondary to atrophic testes. Quasi-experimental (A-B) analysis provided evidence for the efficacy of testosterone treatment for such a condition.     

A noninvasive index of hemispheric activity

Tympanic thermometers were used to measure fluctuations in the temperature of the left and right hemispheres of 22 normal high school students while performing verbal and nonverbal visual discrimination tasks. The nonverbal task involving face recognition demonstrated the predicted effect of hemispheric bias on performance: The subjects performed better when they showed a relative rise in right-hemisphere temperature. No significant relationship between hemispheric temperature and level of performance was observed during the verbal task, perhaps owing to the opportunity to treat effectively the nonwords as either linguistic strings or visual patterns. It is concluded that tympanic temperature effectively measures hemispheric activity during cognitive processing.     

Recovery of performance during sleep following sleep deprivation in older normal and insomniac adult males

Groups of 12 normal and insomniac male subjects aged 55 to 71 yr. were sleep deprived for 64 hr. In both groups, the sleep loss was preceded by four baseline sleep nights and followed by four recovery nights. Reaction time, immediate recall, sleepiness, and body temperature were measured at approximately 2300, 0115, 0330, 0530, and 0800 during baseline, deprivation and recovery nights. Significant performance or mood differences were not found between the normal and insomniac males on any measure or at any testing period throughout the study. Performance of both groups declined characteristically during sleep loss while subjective sleepiness increased. As in young adults, degraded performance was restored by 8 hr. of recovery sleep. However, subjective sleepiness did not return to baseline levels until early in the second recovery night. It was concluded that chronic insomnia does not result in group performance deficits similar to those seen after chronic sleep loss; and the restorative function of sleep operates as efficiently in older insomniac subjects (who apparently have reduced need to sleep) as in older normal subjects.     

Size of human figure drawing and Goodenough-Harris scores of pediatric oncology patients: a pilot study

Human figure drawings of 12 pediatric oncology patients were significantly smaller in height, width, and area than were drawings of 12 school children and 12 pediatric general surgery patients paired for sex and age. The Goodenough-Harris scores of the cancer patients' drawings were also significantly lower than those of both school and general surgery groups. It is hypothesized that anxiety, lowered self-esteem, and the effects of chemotherapy contributed to these findings.     

Field dependence as a limiting factor in solving a complex learning problem

Subjects in a prior study of complex learning often experienced difficulty in mastering the task because of an apparent reluctance to release one perceptual field and reconstrue the task on a higher cognitive level. It was hypothesized that were this the correct explanation, the faster learners would be more field independent on a measure of field dependence, since independence has been defined in terms of ease in releasing one's attention from the immediate perceptual field. This hypothesis was tested with 22 undergraduate subjects for whom Group Embedded Figures Test scores were correlated with the number of trials to completion on the complex learning task. A moderate but significant correlation supported the hypothesis.     

Lateral eye-movement responses to visual stimuli

The association of left lateral eye-movement with emotionality or arousal of affect and of right lateral eye-movement with cognitive/interpretive operations and functions was investigated. Participants were junior and senior students enrolled in an undergraduate course in developmental psychology. There were 37 women and 13 men, ranging from 19 to 45 yr. of age. Using videotaped lateral eye-movements of 50 participants' responses to 15 visually presented stimuli (precategorized as neutral, emotional, or intellectual), content and statistical analyses supported the association between left lateral eye-movement and emotional arousal and between right lateral eye-movement and cognitive functions. Precategorized visual stimuli included items such as a ball (neutral), gun (emotional), and calculator (intellectual). The findings are congruent with existing lateral eye-movement literature and also are additive by using visual stimuli that do not require the explicit response or implicit processing of verbal questioning.     

Physical exercise, social background, and the well-being of older adult women

28 older women participating in an exercise program were compared to 30 older women not participating in an exercise program on two behavioral measures. There were no significant main effects for participation-nonparticipation in an exercise program. Significant main effects were found, however, for each of three social variables.     

Some comments on Shettel-Neuber and O'Reilly's "handedness and career choice: another look at supposed left/right differences" (1983)

A property of attitudes, namely, the fact that attitudes select facts, is used to comment upon a paper on handedness and career choice.