Occasion setting and drug tolerance

There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance. On the basis of a conditioning analysis of tolerance, we would expect that is should be possible to establish drug-paired cues as occasion setters, as well as conditional stimuli. Using feature-positive discrimination training, we evaluated the contribution of occasion-setting stimuli (as well as CSs) to tolerance to the hypothermic effect of ethanol in rats. The results indicated that a complete associative analysis of drug tolerance should incorporate not only the CS properties of predrug cues, but also the occasion-setting properties of such cues. The findings have implications for interpreting conflicting findings concerning extinction of tolerance and for cue-exposure treatments of addiction.     

Medical Psychology in Brazil

In 1962, Psychology was officially accorded professional status in Brazil. Since then the profession has been undergoing continuous development, but the training of psychologists still suffers from flaws that are reflected in the public heath service, SUS (Sistema Único de Saúde). However, SUS itself is also open to criticism: the service is badly distributed, the number of posts for psychologists is limited, and working conditions are poor. Nevertheless, many positive changes are occurring. These include plans to alter academic training to better meet the needs of the Brazilian population, an expansion of the roles played by psychologists in the health service, and increasing research activity. These and many other changes suggest that the progressive evolution of the profession in Brazil will continue.     

Evaluation of Breast Cancer Patients with Genetic Risk in a University Hospital: Before and After the Implementation of a Heredofamilial Cancer Unit

The identification of patients at risk for breast cancer by genetic testing has proven to reduce breast cancer mortality. In 2010, due to a lack of systematization in hereditary cancer assistance in our center, we implemented a multidisciplinary Heredofamilial Cancer Unit (HFCU). We analyze if the HFCU improved the rates of referrals and preventive management of breast cancer patients with genetic risk. We retrospectively compared family history records, referrals of high-risk patients to genetic counseling, and detection and management of patients with BRCA1/2 mutations in two cohorts of breast cancer patients diagnosed before (first period: 2007–2010) and after the creation of the HFCU (second period: 2010–2013). In the first period, 893 patients were included, and 902 were included in the second. Due to the inability to establish their genetic risk, 142 patients (15.9%) vs. 70 (7.8%) were excluded from analysis (p?<?0.001). Among the evaluable patients, 194 (25.8%) vs. 223 (26.8%) fulfilled one or more risk criteria (p?=?0.65). Family history documentation in patient’s medical records (92.4 vs. 97.8%, p?<?0.001) and referral rate (26.3 vs. 52%, p?<?0.0001) significantly increased in the second period. Eight BRCA1/2 mutations were detected among patients referred in the first period and 17 among those referred to the HFCU. The rate of preventive surgeries in patients with BRCA mutations significantly increased in the second period (25 vs. 76.5%, p?=?0.03). In conclusion, there was a clear improvement in family history records, referrals, and preventive surgeries in breast cancer patients with genetic risk after the implementation of the HFCU.     

Para un análisis gnoseológico de la psicología cognitiva

RESUMEN

La psicología cognitiva es, sin duda, el nombre de una de las corrientes más vigorosas de la psicología contemporánea. El presente trabajo pretende introducir en la polémica algunos conceptos gnoseológicos tomados de la Teoría del Cierre Categorial que puedan contribuir al análisis del significado (no solo histórico) de la psicología cognitiva. La Teoría del Cierre Categorial prefiere atenerse en el análisis de las ciencias en curso, a los procedimientos efectivos de ellas más que a las declaraciones de intenciones, a los prólogos metodológicos de sus cultivadores. Así este artículo se limita a analizar muy brevemente dos procedimientos usados normalmente por los psicólogos cognitivos: La utilización del “modelos computadora” y la utilización de ciertos modelos boolianos algebraicos en el análisis de la mente o de la conciencia cognitiva.     

Crossing No Man's Land: Cooperation From the Trenches

This paper represents an attempt to bridge the gap between rational and psychological models of choice, as represented by expected utility theory and prospect theory, and to show how researchers from different traditions can start to work together on problems of interest to both. A central issue for both models concerns the origin of preferences and how they might be predicted. Two questions of interest to all social scientists are related to the formation of preferences: What determines what people want, and what determines what people do once they know what they want? The incorporation of emotion into models of decision‐making may help users of divergent models find common ground for exploration and investigation.     

Rats with dorsal hippocampal lesions do react to new stimuli but not to spatial changes of known stimuli

The effect of visual distracting stimuli upon the straight alleyway performance of dorsal hippocampectomized Wistar rats was investigated. In comparison with control animals it was observed that dorsal hippocampectomized animals (1) ambulated more during the preexposure phase, (2) acquired at the same rate a running response for food (training phase), (3) reacted similarly to a new visual stimulus (black cards) presented in a sector of the alleyway, and (4) habituated to successive presentations of that stimulus in the same place. (5) However, dorsal hippocampectomized rats did not react, unlike the controls, to the presentation of the same stimulus in another place of the alleyway but (6) reacted to the visual pattern change of the stimulus (now black/white check cards) in the same place. These results indicate that under certain experimental conditions, hippocampus-lesioned animals are capable of interrupting a running response for food in order to explore a new conspicuously located stimulus, habituate to repeated presentations of that stimulus, and to react to a new pattern of visual stimulation. They suggest that hippocampectomized rats do not lose the capacity to react to a new stimulus; the disruption seems to be related to the spatial context of stimulus presentation, supporting a spatial mapping hypothesis of hippocampal function.     

Object Theory and Modal Meinongianism

In this paper, we compare two theories, modal Meinongianism (MM) and object theory (OT), with respect to several issues that have been discussed recently in the literature. In particular, we raise some objections for MM, undermine some of the objections that its defenders raise for OT, and we point out some virtues of the latter with respect to the former.