Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex

Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies (DLB). In the present study we investigate potential mechanisms of such disturbances of consciousness (DOC) in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex (Brodmann's areas 20 and 36) differentiated DLB cases with and without DOC, being 62-66% higher in those with DOC (F=4.5,p=.025). The were no differences between DLB patients with or without DOC in 125I-labeled alpha-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly alpha4 and beta2 subunits.     

Science versus orthodoxy: Anatomy of the congressional condemnation of a scientific article and reflections on remedies for future ideological attacks

In July 1999 the U.S. Congress passed a formal resolution condemning our article on child sexual abuse (CSA), an article in which we concluded, based on 59 meta-analytically reviewed studies using college samples, that the assumed harmfulness of CSA had been overstated (Rind, Tromovitch, & Bauserman, 1998). The condemnation followed months of attacks by social conservatives and by mental health professionals specializing either in curing homosexuality or in treating patients by inducing them to recover memories of CSA. In this article, we detail the chronology behind the attacks. Then we discuss the science behind our meta-analysis, showing that the attacks were specious and that our study employed sound science, advancing the field considerably by close attention to issues of external, internal, and construct validity, as well as precision and objectivity. Next, we discuss orthodoxies and moral panics more generally, arguing that our article was attacked as vehemently as it was because it collided with a powerful, but socially constructed orthodoxy that has evolved over the last quarter century. Finally, we offer reflections and recommendations for fellow researchers, lest this kind of event recur. We focus on the need for greater cognizance of historical attacks on science to anticipate and deflate future attacks. We argue that our research should stand as another reminder among many that sacred-cow issues do not belong in science. We discuss nonscientific advocacy in the social sciences and the need to recognize and counter it. We discuss the failure of psychology to adequately deal with the study of human sexuality, a problem that enabled the faulty attacks on our article, and we suggest directions for becoming more scientific in this area. And last, we raise the issue of how professional organizations might deal more effectively with such attacks in the future.     

Sweetening the Till: The Use of Candy to Increase Restaurant Tipping1

A common practice among servers in restaurants is to give their dining parties an unexpected gift in the form of candy when delivering the check. Two experiments were conducted to evaluate the impact of this gesture on the tip percentages received by servers. Experiment 1 found that customers who received a small piece of chocolate along with the check tipped more than did customers who received no candy. Experiment 2 found that tips varied with the amount of the candy given to the customers as well as with the manner in which it was offered. It is argued that reciprocity is a stronger explanation for these findings than either impression management or the good mood effect.     

Theory of mind and epistemological development: the relation between children's second-order false-belief understanding and their ability to reason about evidence

The study investigates the hypothesis that children's ability to attribute second-order beliefs facilitates their understanding of evidence, as seen in the ability to distinguish between causes and reasons. Seventy-four children 5–7 yr old were given belief and evidence tests. The belief tests assessed their ability to represent and reason from second-order false-beliefs, and the evidence tests assessed their ability to distinguish between the cause of a situation and a person's reason for believing it. The relation between performance on the two tests was determined, taking into account general language and non-verbal reasoning abilities. Results show that performance on the belief test and on the evidence part of the evidence test improved significantly over the age range, and that a significant proportion of variance in the evidence test scores is accounted for by second-order false-belief understanding, over and above that accounted for by general language and non-verbal abilities. The argument is made that second-order false-belief understanding is fundamental to children's epistemological development, underlying not just their understanding of evidence, but also their understanding of inference and truth.     

“Statistical,” “Practical,” and “Clinical”: How Many Kinds of Significance Do Counselors Need to Consider?

The present article reviews and distinguishes 3 related but different types of significance: “statistical,” “practical,” and “clinical.” A framework for conceptualizing the many “practical” effect size indices is described. Several effect size indices that counseling researchers can use, or that counselors reading the literature may encounter, are summarized. A way of estimating “corrected” intervention effects is proposed. It is suggested that readers should expect authors to report indices of “practical” or “clinical” significance, or both, within their research reports; and it is noted that indeed some journals now require such reports.     

Psychological Adjustment to Breast Cancer

Breast cancer remains a highly prevalent and extraordinarily stressful experience for hundreds of thousands of women each year in the United States and around the world. Psychological research has provided a picture of the emotional and social impact of breast cancer on patients' lives, and of factors associated with better versus worse adjustment. Psychosocial interventions have been beneficial in decreasing patients' distress and enhancing their quality of life. Recent research also suggests that psychological factors may be related to potentially important biological disease-related processes. In addition to providing an understanding of the psychological factors in breast cancer, research in this area has provided a framework for research on adaptation to health-related stress in general.     

An exploratory study of the perceptions and experiences of further education amongst the young long‐term unemployed

The aim of this study was to explore, in depth, the perceptions and experiences of Further Education (FE) amongst the young long‐term unemployed. Semi‐structured interviews were conducted with 16 long‐term unemployed youths of 18–25 years of age divided into three groups: those with no experience of FE; those having recently dropped out of FE; and those currently studying in FE. Grounded theoretical analysis highlighted the importance of both responses to and institutional aspects of unemployment. The impact of unemployment, poor previous educational experience and perceived irrelevance of FE are key barriers to learning. Those that enter FE may drop out as a result of both material and psychosocial factors. Those that stay on commonly emphasize both social support and personal agency in decision‐making alongside positive evaluations of FE. In conclusion, limitations of the findings, policy and practical recommendations for successful widening of participation in FE amongst this group are considered. Copyright © 2002 John Wiley & Sons, Ltd.     

Listening in aging adults: from discourse comprehension to psychoacoustics.

Older adults, whether or not they have clinically significant hearing loss, have more trouble than their younger counterparts understanding speech in everyday life. These age-related difficulties in speech understanding may be attributed to changes in higher-level cognitive processes such as language comprehension, memory, attention, and cognitive slowing, or to lower-level sensory and perceptual processes. A complicating factor in determining how these sources might contribute to age-related declines in speech understanding is that they are highly correlated. Experimenters have typically focused either on cognitive declines or sensory declines in artificially optimized test conditions. In contrast, our approach focuses on the complex interactions between age-related changes in cognitive and perceptual factors that affect spoken language comprehension, especially in nonideal, realistic conditions. In this article, we describe our attempts to systematically investigate sensory-cognitive interactions in controlled experimental situations. We begin by looking at experimental conditions that closely approximate everyday listening, and show that older adults do indeed experience deficits in spoken language comprehension relative to younger adults in these conditions. We then review further experiments designed to isolate more precisely the cognitive and perceptual sources of these age-related differences and how they vary with listening condition. In large part, we find that age-related changes in speech understanding are a consequence of auditory declines.     

Are University Professors Qualified to Teach Ethics?

In the light of recent talk in Canadian business schools about the importance of teaching courses in business ethics, the authors ask whether business professors have the qualifications required to teach business ethics. They point to various ethical dilemmas that arise in a collegial setting and argue that academics who teach business ethics have to first understand the complex ethical situations in which they find themselves if business ethics is to be taught in a meaningful way.