Methamphetamine abuse and impairment of social functioning: a review of the underlying neurophysiological causes and behavioral implications

The highly addictive drug methamphetamine has been associated with impairments in social cognitions as evidenced by changes in users' behaviors. Physiological changes in brain structure and functioning, particularly in the frontal lobe, have also been identified. The authors propose a biopsychosocial approach to understanding the effects of methamphetamine addiction by relating the physiological effects of the drug to the behaviors and social cognitions of its users, through the application of the theory of mind paradigm. Although onset of methamphetamine use has been linked to the desire for socialization, chronic use has been associated with an increase in depression, aggressiveness, and social isolation, behaviors that also implicate involvement of the frontal lobe. The reviewed literature provides strong circumstantial evidence that social-cognitive functioning is significantly impacted by methamphetamine use and that the social isolation, depression, and aggressiveness associated with chronic use is due to more than just the social withdrawal associated with addiction. Treatment considerations for methamphetamine must therefore consider the role of social cognition, and pharmacological responses must address the documented impact of the drug on frontal lobe functioning.     

Children with Comorbid Speech Sound Disorder and Specific Language Impairment are at Increased Risk for Attention-Deficit/Hyperactivity Disorder

This study focuses on the comorbidity between attention-deficit/hyperactivity disorder (ADHD) symptoms and speech sound disorder (SSD). SSD is a developmental disorder characterized by speech production errors that impact intelligibility. Previous research addressing this comorbidity has typically used heterogeneous groups of speech-language disordered children. This study employed more precise speech-language diagnostic criteria and examined ADHD symptomatology in 108 SSD children between the ages of 4 and 7 years old with specific language impairment (SLI) (n = 23, 14 males, 9 females) and without SLI (n = 85, 49 males, 36 females). We also examined whether a subcategory of SSD, persistent (n = 39, 25 males, 14 females) versus normalized SSD (n = 67, 38 males, 29 females), was associated with ADHD and/or interacted with SLI to predict ADHD symptomatology. Results indicated that participants in the SSD + SLI group had higher rates of inattentive ADHD symptoms than those in the SSD-only and control groups. In addition, an unexpected interaction emerged such that children with SLI and normalized-SSD had significantly higher ADHD inattentive ratings than the other subgroups. A proposed explanation for this interaction is discussed.     

The forked tongue and edge detection in snakes (Crotalus oreganus): an experimental test

Many stimulus-detection systems are lateralized to allow for simultaneous comparison of paired stimuli. It has been hypothesized that the deeply forked tongue of snakes and some derived lizards functions as a chemical edge detector where cues gathered by each tine are kept separate to provide two points of lateral odor assessment by the central nervous system via vomeronasal input. While following a chemical trail, one time can be on the trail, the other off, and such differential information prompts the snake to turn back to the trail. The authors tested this hypothesis in rattlesnakes within a predatory context by unilaterally severing the vomeronasal nerves. If edge detection is used by snakes during prey trailing, then unilateral denervation should disrupt trailing ability. The authors found no change in the seven separate trailing parameters measured. Therefore, they found no support for the edge detection hypothesis as it applies to prey trailing behavior. Instead, the deeply forked tongue may represent a chemosensory specialization to increase odor-sampling area, with snakes and derived lizards detecting only the concentration of chemical trails.     

Dynamic Structure in Diagnostic Structured Interviewing: A Comparative Test of Accuracy and Efficiency

The incorporation of Bayesian logic into diagnostic interviewing may assist with empirically based diagnostic assessment strategies in practice settings, balancing cost effectiveness, administration demands, and accuracy, yet few demonstrations of such a system have been undertaken in the context of mental health diagnosis. The present study represented an initial feasibility demonstration of whether a simplified Bayesian approach offered comparative advantages in interview accuracy and efficiency against a standard assessment procedure. Two different diagnostic algorithms were compared targeting three selected diagnoses: generalized anxiety disorder (GAD), major depressive disorder (MDD), and social phobia (SP). The first algorithm was from a standard semi-structured diagnostic interview, and the second was from a dynamic system using diagnostic base rate information to select interview content. The dynamic algorithm reduced administration time and uniformly matched or improved accuracy over standard procedures. Preparation of this article was supported in part by National Institute of Mental Health Grant R03 MH60134, an award from the University of Hawai‘i Research Council, and awards from the Hawaii Departments of Health and Education to the first author.     

Maternal depression and parenting in relation to child internalizing symptoms and asthma disease activity.

This study tested a hypothesized model of the relationship between maternal depression and child psychological and physical dysfunction mediated by parenting and medication adherence. A sample of 242 children with asthma, aged 7 to 17, participated with their mothers. Maternal depression was assessed by self-report, and parenting was observed during family interaction tasks. Internalizing symptoms were assessed by self- and clinician reports. Asthma disease activity was assessed according to National Heart Lung and Blood Institute guidelines, and medication adherence was evaluated with a 24-hr recall method. Structural equation modeling indicated that negative parenting partially mediated the relationship between maternal depression and child internalizing symptoms. Child internalizing symptoms, in turn, mediated the associations between both maternal depression and negative parenting and asthma disease activity. Medication adherence did not mediate the link from maternal depression to disease activity. Thus, maternal depression was linked to child psychological dysfunction both directly and indirectly via negative parenting but linked to physical dysfunction only indirectly through psychological dysfunction. These findings suggest that diagnosing and treating depression in mothers of children with asthma would enhance child well-being both psychologically and physically.     

The use of indigenous interviewers in a study of latino men who have sex with men: A research note

The use of indigenous researchers has long been practiced in ethnographic research; a similar use of indigenous personnel has not been as commonly undertaken in interview studies of men who have sex with men (MSM). This research note reports on the use of indigenous interviewers in a study of Latino MSM’s perceptions about sexual relationships and behaviors. The full study explores sexual relationships among Latino MSM, and HIV risk behaviors undertaken by a population of MSM residing in a community in southern California. This research note describes both the strengths and limitations that arise from employing indigenous interviewers for improving the overall quality of sensitive data. Benefits discussed include improved access to an otherwise highly restricted group, enhanced rapport-building capabilities, and greater understanding of language unique to the study population. Limitations discussed include the use of previously untrained interview personnel and age and gender issues.     

A Metacompatibilist Account of Free Will: Making Compatibilists and Incompatibilists More Compatible

The debate over free will has pittedlibertarian insistence on open alternativesagainst the compatibilist view that authenticcommitments can preserve free will in adetermined world. A second schism in the freewill debate sets rationalist belief in thecentrality of reason against nonrationalistswho regard reason as inessential or even animpediment to free will. By looking deeperinto what motivates each of these perspectivesit is possible to find common ground thataccommodates insights from all those competingviews. The resulting metacompatibilist view offree will bridges some of the differencesbetween compatibilists and incompatibilists aswell as between rationalists andnonrationalists, and results in a free willtheory that is both more philosophicallyinclusive and more firmly connected tocontemporary research in psychology andbiology.     

The Sad Truth: Optimism, Pessimism, and Pragmatism

Pragmatists (such as William James) recommend optimism as a successful strategy, and recent psychological research has confirmed its value. But optimism comes at a price: optimists are less accurate in their assessments and expectations than are pessimists. Thus optimism 'proves itself to be good in the way of belief', and by pragmatic standards should count as true; but that makes the accuracy costs of optimism invisible (the problem is only exacerbated by Rorty's recommendation that pragmatists stop speaking of truth altogether). The problem prevents pragmatists from offering a Darwinian explanation of why pessimism survives, and also blocks any pragmatist account of the well-documented and highly successful exploratory behavior of many animal species.     

Idiodynamic Profiles of Cardiovascular Activity: A P-technique Approach

A study was conducted to expand the conventional view of cardiovascular (CV) reactivity by using the idiodynamic paradigm for investigation of individuals. Patterns of autonomic CV regulation were assessed in six subjects across diverse laboratory tasks on three separate occasions. Individual CV profiles were derived from these data with P-technique factor analysis, and then group aggregated with chain P-technique. The composite pattern suggested a three-component solution consisting of cardiac rate, cardiac contractility, and peripheral resistance factors. Individual profiles were compared to the composite pattern; these profiles differed in the number of components derived, percentage variance explained by these components, and relative dominance of specific CV components. A hypothesis that emerged is that the subjects differed in the complexity of CV control. It appears that the idiodynamic framework, combined with novel research designs and statistical methods, may help expand the view of CV reactivity beyond the traditional unitary view as response magnitude.     

Analogue Measures of DSM-IV Mood and Anxiety Disorders Based on Behavior Checklists

Although symptom checklists are commonly used to assess childpsychopathology, confusion arises due to differences between empirically derived checklist syndromes and rationally derived DSM-IV diagnostic categories. This paper explores analogue measures of DSM-IV mood and anxiety disorders created using items from the Youth Self-Report and Child Behavior Checklist (T. M. Achenbach, 1991a, 1991b) that parallel DSM-IV symptoms. In a matched sample of clinically referred and nonreferred adolescents, analogue measures demonstrated expected patterns of age differences, sex differences, and comorbidity. Meeting criteria for an analogue diagnosis was also associated with referral for mental health services and poor social competence. Informant effects are highlighted and the potential benefits and limitations of using existing behavior checklists to assess DSM disorders are discussed. These findings suggest the utility of checklists in identifying analogues of anxiety and mood disorders in children and adolescents.