Review Essay: The Divided Church and its Theology

Book reviewed in this article:
Ephraim Radner, The end of the Church: A Pneumatology of Christian Division in the West     

Hyperactivity and Learning Deficits in Transgenic Mice Bearing a Human Mutant Thyroid Hormone β1 Receptor Gene

Resistance to thyroid hormone (RTH) is a human syndrome mapped to the thyroid receptor β (TRβ) gene on chromosome 3, representing a mutation of the ligandbinding domain of the TRβ gene. The syndrome is characterized by reduced tissue responsiveness to thyroid hormone and elevated serum levels of thyroid hormones. A common behavioral phenotype associated with RTH is attention deficit hyperactivity disorder (ADHD). To test the hypothesis that RTH produces attention deficits and/or hyperactivity, transgenic mice expressing a mutant TRβ gene were generated. The present experiment tested RTH transgenic mice from the PV kindred on behavioral tasks relevant to the primary features of ADHD: hyperactivity, sustained attention (vigilance), learning, and impulsivity. Male transgenic mice showed elevated locomotor activity in an open field compared to male wild-type littermate controls. Both male and female transgenic mice exhibited impaired learning of an autoshaping task, compared to wild-type controls. On a vigilance task in an operant chamber, there were no differences between transgenics and controls on the proportion of hits, response latency, or duration of stimulus tolerated. On an operant go/no-go task measuring sustained attention and impulsivity, there were no differences between controls and transgenics. These results indicate that transgenic mice bearing a mutant human TRβ gene demonstrate several behavioral characteristics of ADHD and may serve a valuable heuristic role in elucidating possible candidate genes in converging pathways for other causes of ADHD.     

Gravity does rule for falling events

Hood (1995) reported a vertical invisible displacement task where the goal was to find a ball that was dropped down one of three chimneys connected to three hiding boxes below by opaque tubes. Preschool children exhibited perseverative search at the box directly below the chimney where the ball was dropped even though the tubes were always visible and the children were given numerous trials and feedback. This behavior was interpreted as a naive theory of gravity. The current study set out to test the naive gravity theory hypothesis by reversing the motion of the event on a television. On half of the trials the object appeared to fall up the tube into one of the boxes which were now on the top of the apparatus. There were significantly more errors for ‘down’ trials as compared to ‘up’ trials which supports the hypothesis that children are biased to infer that falling objects travel in a straight line whereas anti-gravity events do not conform to this naive theory.     

Good intentions and bad sociology: New age authenticity and social roles

Drawing on New Age biographies, this essay questions the assertion of New Agers that enlightenment and authentiáty improve personal and social relationships, and offers a sociological justification for the imposition of social order and for the use of roles in the mediation of relationships.     

Concurrent validity and Holland's theory

This study was designed to explore two areas: (1) the concurrent validity of Holland's theory for employed men using four different operational definitions of vocational orientation, and (2) the relationships among all possible combinations of same named scales across the four inventories. Concurrent validity was studied by administering the Vocational Preference Inventory, the Self Directed Search, and the Holland Scales (Set I and Set II) to 153 male workers established in occupational environments consistent with Holland's six vocational environments. The results revealed that five scales of the VPI and of the Holland Scales (Set I and Set II) and four scales of the SDS successfully differentiated the occupational groups consistent with Holland's theoretical framework. The correlation coefficients for same named scales for all possible combinations of the four inventories were all found to be significant. In general, the findings of this study tend to support the concurrent validity of Holland's theory for employed men.