Behavioral pharmacology of the odor span task: Effects of flunitrazepam,ketamine, methamphetamine and methylphenidate

The Odor Span Task is an incrementing non‐matching‐to‐sample procedure that permits the study of behavior under the control of multiple stimuli. Rats are exposed to a series of odor stimuli and selection of new stimuli is reinforced. Successful performance thus requires remembering which stimuli have previously been presented during a given session. This procedure has been frequently used in neurobiological studies as a rodent model of working memory; however, only a few studies have examined the effects of drugs on performance in this task. The present experiments explored the behavioral pharmacology of a modified version of the Odor Span Task by determining the effects of stimulant drugs methylphenidate and methamphetamine, NMDA antagonist ketamine, and positive GABA_A modulator flunitrazepam. All four drugs produced dose‐dependent impairment of performances on the Odor Span Task, but for methylphenidate and methamphetamine, these occurred only at doses that had similar effects on performance of a simple odor discrimination. Generally, these disruptions were based on omission of responding at the effective doses. The effects of ketamine and flunitrazepam were more selective in some rats. That is, some rats tested under flunitrazepam and ketamine showed decreases in accuracy on the Odor Span Task at doses that did not affect simple discrimination performance. These selective effects indicate disruption of within‐session stimulus control. Overall, these findings support the potential of the Odor Span Task as a baseline for the behavioral pharmacological analysis of remembering.     

Raising One Eyebrow and Re‐envisioning Justice,Gender, and the Family

As part of a celebration of Susan Okin's Justice, Gender, and the Family (JGF), this article notes how some impacts of the book were so accepted that their original source (JGF) has been forgotten. It goes on to make three critical arguments about 1) Okin's pared‐down account of gender injustice, 2) her choice to embrace the Rawlsian distributive view of justice, and 3) her treatment of the family as the linchpin of gender injustice.     

Posttraumatic stress and depression: potential pathways to disease burden among heart failure patients

Background and Objectives: Posttraumatic stress disorder (PTSD) and Major Depressive Disorder (MDD) are associated with high disease burden. Pathways by which PTSD and MDD contribute to disease burden are not understood. Design: Path analysis was used to examine pathways between PTSD symptoms, MDD symptoms, and disease burden among 251 low-income heart failure patients. Methods: In Model 1, we explored the independent relationship between PTSD and MDD symptoms on disease burden. In Model 2, we examined the association of PTSD symptoms and disease burden on MDD symptoms. We also examined indirect associations of PTSD symptoms on MDD symptoms, mediated by disease burden, and of PTSD symptoms on disease burden mediated by MDD symptoms. Results: Disease burden correlated with PTSD symptoms (r = .41; p < .001) and MDD symptoms (r = .43; p < .001) symptoms. Both models fit the data well and displayed comparable fit. MDD symptoms did not mediate the association of PTSD symptoms with disease burden. Disease burden did mediate the relationship between PTSD symptoms and MDD symptoms. Conclusions: Results support the importance of detection of PTSD in individuals with disease. Results also provide preliminary models for testing longitudinal data in future studies.     

Novel evidence in support of the bilingual advantage: Influences of task demands and experience on cognitive control and working memory

The bilingual advantage—enhanced cognitive control relative to monolinguals—possibly occurs due to experience engaging general cognitive mechanisms in order to manage two languages. Supporting this hypothesis is evidence that bimodal (signed language–spoken language) bilinguals do not demonstrate such an advantage, presumably because the distinct language modalities reduce conflict and control demands. We hypothesized that the mechanism responsible for the bilingual advantage is the interplay between (a) the magnitude of bilingual management demands and (b) the amount of experience managing those demands. We recruited adult bimodal bilinguals with high bilingual management demands and examined cognitive control and working memory capacity longitudinally. After gaining experience managing high bilingual management demands, participants outperformed themselves from 2 years earlier on cognitive abilities associated with managing the bilingual demands. These results suggest that cognitive control outcomes for bilinguals vary as a function of the mechanisms recruited during bilingual management and the amount of experience managing the bilingual demands.     

Making the Decision to Participate in Predictive Genetic Testing for Arrhythmogenic Right Ventricular Cardiomyopathy

This paper describes the experience of predictive genetic testing for Arrhythmogenic Right Ventricular Cardiomyopathy in the context of novel gene discovery. Two approaches to making the decision to engage in genetic testing were apparent: the decision to be tested either (a) develops gradually over time or (b) happens so quickly that it is felt as a “fait accompli.” Six key factors that influenced the particular approach taken by the participants were identified: (1) scientific process—available and relevant predictive genetic test; (2) numerous losses or deaths within the family; (3) physical signs and symptoms of disease; (4) gender; (5) sense of relational responsibility or moral obligation to other family members; and (6) family support. This study found that at risk individuals juxtapose scientific knowledge against their experiential knowledge and the six identified factors in order to make the decision to participate in genetic testing. Recommendations include the creation of a relational space within which to provide psychological counselling and assessment for the six identified factors that shape the decision to engage in predictive genetic testing.     

Pet Peeves and Happiness: How Do Happy People Complain?

The present study was designed to investigate the relationships among mindfulness, happiness, and the expression of pet peeves. Previous research has established a positive correlation between happiness and mindfulness, but, to date, no research has examined how each of these variables is related to complaining in the form of pet peeves. Four hundred ten male and female college students listed the pet peeves they had with a current or former relationship partner. They also completed measures of happiness, positive and negative affect, depression, mindfulness, relationship satisfaction, and satisfaction with life. Pet peeves were negatively correlated with relationship satisfaction, well-being, and mindfulness. Consistent with hypotheses, support was found for the mediating role of mindfulness in the relationship between happiness and pet peeves.     

Thin Is In? Think Again: The Rising Importance of Muscularity in the Thin Ideal Female Body

Research has documented an increased emphasis on fitness in media targeting women. However, it is unclear whether this emphasis has resulted in increased muscularity in the perceived ideal female body shape. We sought to evaluate whether the ideal female figure has incorporated increased muscularity into the existing ideal body type that already emphasizes thinness. In Study 1, 78 female undergraduates evaluated images of U.S. beauty pageant winners over the past 15 years on dimensions of thinness, muscularity, and attractiveness. Results indicated that muscularity and thinness ratings of pageant winners significantly increased over time. In Study 2, 64 female undergraduates evaluated two different versions of the same image of a model: a Thin Muscular image and a Thin Only image in which the appearance of muscularity was removed through digital editing. When images were presented in pairs, results indicated that participants found the Thin Muscular image more attractive than the Thin Only image. These results suggest that the current perceived ideal female figure includes both extreme thinness and muscularity and that women prefer this muscular thin figure to a solely thin figure. These findings have implications for clinical treatments related to body image, compulsive exercise, and media literacy.     

Dyad Practice Impacts Self-Directed Practice Behaviors and Motor Learning Outcomes in a Contextual Interference Paradigm

We studied dyad practice to determine whether and how alternating practice blocks with a partner impacts self-directed practice scheduling, learning, and perceptions of practice. Participants were assigned to be Partner 1 (P1) or 2 (P2). P1s had a blocked, random, or self-directed schedule, while all P2s self-directed practice of 3, differently-timed keystroke-sequences. P2s showed both own error-dependent practice (switching sequences following better performance) and partner-dependent practice, with the partner's schedule impacting sequence selection and switching frequency. A partner's schedule also impacted learning. Random practice resulted in better timing accuracy than blocked practice for both partners in an immediate and delayed retention test. These data give evidence that self-directed practice behaviors and learning outcomes are modulated by a partner's practice schedule.