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Extracellular signal-regulated kinase activity in the entorhinal cortex is necessary for long-term spatial memory 总被引:2,自引:0,他引:2 下载免费PDF全文
Lesion studies have provided evidence that the entorhinal cortex (EC) participates in spatial memory. However, the molecular cascades that underlie memory-associated changes in the EC and its specific role in spatial memory, however, have not been clearly delineated. Recently, it has been shown that activation of extracellular signal-regulated kinase (Erk, a mitogen-activated protein kinase family member) in the dorsal hippocampus is necessary for spatial memory. To examine whether similar mechanisms are used for spatial memory storage in the EC, Erk activity was inhibited after training in the Morris water maze. Bilateral infusion of the mitogen-activated protein kinase kinase inhibitor PD098059 into the EC immediately after training resulted in a memory deficit observed during a retention test performed 48 h later. This deficit was abolished with pretraining in a different water maze in which animals were able to learn the general task requirements and the appropriate search strategies. The absence of a deficit indicates that Erk activity in the EC may be involved in storing the task requirements or the search strategies. The findings presented in this article are consistent with the idea that the EC is involved in spatial memory and indicate that Erk activity is necessary for memory consolidation in this structure. 相似文献
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Crystallization of desire and crystallization of discontent in narratives of life-changing decisions
Two studies of adults examined personal narratives of life-changing decisions in relation to personality and well-being. Participants whose decision narratives emphasized a crystallization of desire (i.e., approaching a desired future) rather than a crystallization of discontent (i.e., escaping an undesired past; Baumeister, 1991, 1994) reported higher well-being, fewer avoidance strivings, lower Neuroticism (in Study 1 only), and better decision outcomes (in Study 2). However, neither strivings, traits, nor outcomes accounted for the relationship between crystallization of desire and well-being. The discussion considers the roles of life-changing decisions and personal narratives in research on personality, well-being, and positive personal development. 相似文献
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Garcia DM Reser AH Amo RB Redersdorff S Branscombe NR 《Personality & social psychology bulletin》2005,31(6):769-780
The authors extend recent research concerning the social costs of claiming discrimination by examining men's and women's responses to in-group and out-group targets who either blamed a failing grade on discrimination or answer quality. Although participants generally responded more negatively to targets who blamed discrimination, rather than answer quality, dislike was greatest and gender group identification was lowest when participants evaluated an in-group target. Moreover, an in-group target who claimed discrimination was perceived as avoiding personal responsibility for outcomes to a greater extent than was a similar out-group target. Perceptions that the target avoided outcome responsibility by claiming discrimination were shown to mediate the relationship between attribution type and dislike of the in-group target. The authors discuss their results in terms of intragroup processes and suggest that social costs may especially accrue for in-group members when claiming discrimination has implications for the in-group's social identity. 相似文献
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Three experiments examined the role of three distinctive perceptual factors in recognition and recall memory. Using a subject-paced presentation rate, the first two experiments (recognition and recall) examined (1) the number of phonological-to-orthographic neighbors, (2) phonological-to-orthographic consistency, and (3) orthographic-to-phonological consistency. The third experiment (recall) reexamined the number of phonological-to-orthographic neighbors, using an experimenter-paced presentation rate of 2 sec per item. In both recognition and recall memory tasks, the number of phonological-to-orthographic neighbors influenced memory performance, whereas the two types of consistency did not. The results indicate that having fewer phonological-to-orthographic neighbors (i.e., having distinct mappings between orthography and phonology, and between phonology and orthography, e.g., pulp) relieve words from interference in episodic memory tests for such words. Furthermore, words that are indistinct in terms of these mappings (e.g., tuck) are subject to interference from words with similar representations (e.g., luck, buck, stuck), and this weakens the memory trace for a particular word. 相似文献
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The present study examined the perceptions school-age children have of stutterers. Four groups of fourth and fifth grade students viewed a videotape with either the speaker stuttering or not stuttering while reading a poem. A semantic differential scale of bi-polar adjective pairs was used to rate the speaker on intelligence and personality traits. The current study found that there is a significant difference between school-age children's perceptions of stutterers and nonstutterers with the ratings for the disfluent speaker more negative than the ratings for the fluent speaker. It was found that children did not rate personality and intelligence related traits differently. This information can be used to validate the need for education regarding stuttering for children and those who work with children. EDUCATIONAL OBJECTIVES: The reader will learn about and be able to (1). identify perceptions of stutterers by a variety of groups; (2). discuss the implications of research on perceptions of stutterers; and (3). compare/contrast children and adults and their perceptions. 相似文献
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Women perform better than men on tests of verbal memory, but the nature of this advantage has not been precisely established. To examine whether phonemic memory is a factor in the female advantage, we presented, along with other verbal memory tasks, one containing nonsense words. Overall, there was the expected female advantage. However, an examination of the individual tests showed female superiority in recall of the real words but not the nonsense words. 相似文献
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The turbulence of the new economy puts demands on organizations to respond rapidly, flexibly and creatively to changing environments. Meetings are one of the organizational sites in which organizational actors “do” creativity; interaction in groups can be an important site for generating creative ideas and brainstorming. Additionally, Blount (2004) demonstrated the importance of organizational temporalities for group performance. We draw on both of these literatures and examine how temporal structures influence the climate for creativity, or the extent to which creativity is fostered, within groups. Specifically, we develop a hypothesis linking organization‐ and job‐level temporal structures to the extent to which managers structure meetings with a climate supportive of creativity. Our results demonstrate that a nuanced relationship exists between temporal structures and creative climate such that certain temporal structures appear to either enhance or decrease the creative climate of meetings. We end with a discussion of the implications of the findings for management. 相似文献
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The purpose of the current study was to examine the degree to which instruction based on stimulus equivalence procedures could be used to teach single-subject design methodology to graduate-level professionals through a Web-based course management system known as Blackboard (see http://www.blackboard.com). Specifically, we used the stimulus equivalence paradigm to teach relations among the names, definitions, graphical representations of the designs, and two practical scenarios of when it would be appropriate to implement each design. Most participants demonstrated the emergence of untaught relations, and some participants showed generalization to novel vignettes and graphs. Relations largely were not maintained at follow-up but were retaught. 相似文献