Activation of the infralimbic cortex in a fear context enhances extinction learning

Activation of the infralimbic region (IL) of the medial prefrontal cortex (mPFC) reduces conditioned fear in a variety of situations, and the IL is thought to play an important role in the extinction of conditioned fear. Here we report a series of experiments using contextual fear conditioning in which the IL is activated with the GABAa antagonist picrotoxin (Ptx) during a single extinction session in the fear context. We investigate the impact of this manipulation on subsequent extinction sessions in which Ptx is no longer present. First, we demonstrate that a single treatment with intra-IL Ptx administered in a conditioned fear context greatly accelerates the rate of extinction on the following days. Importantly, IL-Ptx also enhances extinction to a different fear context than the one in which IL-Ptx was administered. Thus, IL-Ptx primes extinction learning regardless of the fear context in which the IL was initially activated. Second, activation of the IL must occur in conjunction with a fear context in order to enhance extinction; the extinction enhancing effect is not observable if IL-Ptx is administered in a neutral context. Finally, this extinction enhancing effect is specific to the IL for it does not occur if Ptx is injected into the prelimbic region (PL) of the mPFC. The results indicate a novel persisting control of fear induced by activation of the IL and suggest that IL activation induces changes in extinction-related circuitry that prime extinction learning.     

Special Considerations in the Adaptation of Cognitive Behavioral Therapy for Insomnia With Active-Duty U.S. Army Personnel

Insomnia is highly prevalent among active-duty military service members. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a well-established and effective treatment; however, research and treatment recommendations have primarily focused on civilian or veteran populations. A multitude of military-specific factors directly impact service members’ sleep and the subsequent treatment recommendations. This article provides treatment considerations for the use of CBT-I with active-duty U.S. Army personnel. First, an overview of the theoretical model of insomnia, including military-specific predisposing, precipitating, and perpetuating factors, is presented, followed by a review of common comorbid conditions among service members with insomnia. Finally, discussion focuses on considerations and strategies for implementing components of CBT-I with service members, managing sleep during deployments, and adjusting sleep to accommodate overnight duties. Additional training resources and supplemental video examples (with actors) are provided.     

Touch communicates distinct emotions

The study of emotional signaling has focused almost exclusively on the face and voice. In 2 studies, the authors investigated whether people can identify emotions from the experience of being touched by a stranger on the arm (without seeing the touch). In the 3rd study, they investigated whether observers can identify emotions from watching someone being touched on the arm. Two kinds of evidence suggest that humans can communicate numerous emotions with touch. First, participants in the United States (Study 1) and Spain (Study 2) could decode anger, fear, disgust, love, gratitude, and sympathy via touch at much-better-than-chance levels. Second, fine-grained coding documented specific touch behaviors associated with different emotions. In Study 3, the authors provide evidence that participants can accurately decode distinct emotions by merely watching others communicate via touch. The findings are discussed in terms of their contributions to affective science and the evolution of altruism and cooperation.     

Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons

Mutations in the neuronal-specific microtubule-binding protein TAU are associated with several dementias and neurodegenerative diseases. However, the effects of elevated TAU accumulation on behavioral plasticity are unknown. We report that directed expression of wild-type vertebrate and Drosophila TAU in adult mushroom body neurons, centers for olfactory learning and memory in Drosophila, strongly compromised associative olfactory learning and memory, but olfactory conditioning-relevant osmotactic and mechanosensory responses remained intact. In addition, TAU accumulation in mushroom body neurons did not result in detectable neurodegeneration or premature death. Therefore, TAU-mediated structural or functional perturbation of the microtubular cytoskeleton in mushroom body neurons is likely causal of the behavioral deficit. These results indicate that behavioral plasticity decrements may be the earliest detectable manifestations of tauopathies.     

A comparison of stimulus set size on tact training for children with autism spectrum disorder

Previous studies on skill acquisition have taught targets in stimulus sets composed of different numbers of stimuli. Although the rationale for selection of a stimulus set size is not clear, the number of target stimuli trained within a set is a treatment decision for which there is limited empirical support. The current investigation compared the efficiency of tact training in 4 stimulus set sizes, each of which included 12 stimuli grouped into (a) 4 sets of 3 stimuli, (b) 3 sets of 4 stimuli, (c) 2 sets of 6 stimuli, and (d) 1 set of 12 stimuli. Results of all 4 participants with autism spectrum disorder show tact training with larger (i.e., 6 and 12) stimulus set sizes was more efficient than training with smaller (i.e., 3 and 4) stimulus set sizes.     

An exploration of the interrater agreement of visual analysis with and without context

Visual analysis is integral to the analysis of single-case experimental design (SCED) data. Previous studies have shown that many factors may influence the interrater agreement (IRA) of visual analysis. One factor that has received little direct attention is the impact of contextual information. In the current study, authors of recently published SCED studies were asked to make judgments regarding functional relations based on published datasets that met criteria for design quality. Respondents were randomly assigned to view graphs with or without contextual information and the degree of interrater agreement was compared. Results revealed that contextual information had no impact on IRA for decisions of a functional relation. IRA was high across both groups for 6 of the 7 datasets examined. Implications and recommendations based on these results are discussed.     

Children's understanding of habitual behaviour

Research into the development of Theory of Mind (ToM) has shown how children from a very early age infer other people's goals. However, human behaviour is sometimes driven not by plans to achieve goals, but by habits, which are formed over long periods of reinforcement. Habitual and goal‐directed behaviours are often aligned with one another but can diverge when the optimal behavioural policy changes without being directly reinforced (thus specifically hobbling the habitual learning strategy). Unlike the flexibility of goal‐directed behaviour, rigid habits can cause agents to persist in behaviour that is no longer adaptive. In the current study, all children predict agents will tend to behave consistently with their goals, but between the ages of 5 and 10, children showed an increasing understanding of how habits can cause agents to persistently take suboptimal actions. These findings stand out from the typical way the development of social reasoning is examined, which instead focuses on children's increasing appreciation of how others' beliefs or expectations affect how they will act in service of their goals. The current findings show that children also learn that under certain circumstances, people's actions are suboptimal despite potentially ‘knowing better.’     

Short-term predictive effects of the looming cognitive style on anxiety disorder symptoms under restrictive methodological conditions

The looming cognitive style (LCS), an overarching cognitive vulnerability for anxiety syndromes, pertains to a tendency to construct dynamic expectations (mental scenarios, images) of negative events as progressively increasing in danger and rapidly escalating in risk. This study tested the hypothesis that the LCS has functions as a cognitive antecedent and moderator for even short-term changes over a brief time interval in anxiety syndromes (worry, obsessive-compulsive disorder (OCD) symptoms, social anxiety, general anxiety) under restrictive methodological conditions. These included: (a) a one-week interval during which very little changes in anxiety were observed, and (b) controlling for participants' depression and intolerance of uncertainty. As hypothesized by our model, the looming cognitive style predicted short-term changes in worry and OCD symptoms over the week interval, and tended to predict changes in social (audience) anxiety. This style also functioned as a moderator and predicted changes in OCD symptoms among participants already high on this anxiety outcome. Intolerance of uncertainty predicted changes in social (audience) anxiety but not changes in OCD symptoms or worry. These findings support the looming vulnerability theory of anxiety, and encourage further attention into the possible role of the LCS as a cognitive antecedent and moderator of changes in a spectrum of anxiety syndromes.     

Rationally Functional Dependence

Two different types of functional dependencies are compared: dependencies that are functional due to the laws of nature and dependencies that are functional if all involved agents behave rationally. The first type of dependencies was axiomatized by Armstrong. This article gives a formal definition of the second type of functional dependencies in terms of strategic games and describes a sound and complete axiomatization of their properties. The axiomatization is significantly different from the Armstrong’s axioms.