Parents’ Understanding of Genetics and Heritability

Parents have the opportunity to educate their children to facilitate behaviours and lifestyle habits that may prevent or delay genetic disease, or mitigate predispositions within the family. We sought to determine parents’ understanding of genetic knowledge and heritability. Using a quantitative survey methodology 108 volunteer participants were surveyed from a convenience sample of all parents/caregivers within the waiting room of a general children’s outpatient clinic. Results indicated that average genetic knowledge levels were fairly high, with the majority of participants scoring 70–80 % correct on knowledge-based questions. Further, scores were found to be positively correlated with education, but inversely correlated with self-perceived knowledge. This finding suggests that participants with less experience tended to overestimate their knowledge. We suggest that gaps in knowledge of genetics and heritability could be improved by using educational interventions such as media campaigns, provision of informational brochures, or changes to current high school curriculum which would increase exposure to genetics and heritability for both parents and children.     

AMPA receptor endocytosis in rat perirhinal cortex underlies retrieval of object memory

Mechanisms consistent with long-term depression in the perirhinal cortex (PRh) play a fundamental role in object recognition memory; however, whether AMPA receptor endocytosis is involved in distinct phases of recognition memory is not known. To address this question, we used local PRh infusions of the cell membrane-permeable Tat-GluA2(3Y) interference peptide or a scrambled control to block the endocytosis of AMPA receptors during the encoding, consolidation, or retrieval phase of object recognition memory. Tat-GluA2(3Y) infusion before the encoding and consolidation phases did not alter recognition memory. In contrast, Tat-GluA2(3Y) infusion prior to the retrieval phase disrupted object recognition memory. The present results indicate a distinct role for AMPA receptor endocytosis in the retrieval of visual recognition memory.     

Evaluation of the immediate and subsequent effects of response interruption and redirection on vocal stereotypy

We evaluated 2 3-component multiple-schedule sequences-a response interruption and redirection (RIRD) treatment sequence and a no-interaction control sequence-using a multielement design. With this design, we were able to evaluate the immediate and subsequent effects of RIRD on 2 participants' vocal stereotypy. For both participants, RIRD produced an immediate decrease in vocal stereotypy and did not result in a subsequent increase.     

Feasibility and Preliminary Outcomes of a School-Based Mindfulness Intervention for Urban Youth

Youth in underserved, urban communities are at risk for a range of negative outcomes related to stress, including social-emotional difficulties, behavior problems, and poor academic performance. Mindfulness-based approaches may improve adjustment among chronically stressed and disadvantaged youth by enhancing self-regulatory capacities. This paper reports findings from a pilot randomized controlled trial assessing the feasibility, acceptability, and preliminary outcomes of a school-based mindfulness and yoga intervention. Four urban public schools were randomized to an intervention or wait-list control condition (n = 97 fourth and fifth graders, 60.8% female). It was hypothesized that the 12-week intervention would reduce involuntary stress responses and improve mental health outcomes and social adjustment. Stress responses, depressive symptoms, and peer relations were assessed at baseline and post-intervention. Findings suggest the intervention was attractive to students, teachers, and school administrators and that it had a positive impact on problematic responses to stress including rumination, intrusive thoughts, and emotional arousal.     

Activation of the infralimbic cortex in a fear context enhances extinction learning

Activation of the infralimbic region (IL) of the medial prefrontal cortex (mPFC) reduces conditioned fear in a variety of situations, and the IL is thought to play an important role in the extinction of conditioned fear. Here we report a series of experiments using contextual fear conditioning in which the IL is activated with the GABAa antagonist picrotoxin (Ptx) during a single extinction session in the fear context. We investigate the impact of this manipulation on subsequent extinction sessions in which Ptx is no longer present. First, we demonstrate that a single treatment with intra-IL Ptx administered in a conditioned fear context greatly accelerates the rate of extinction on the following days. Importantly, IL-Ptx also enhances extinction to a different fear context than the one in which IL-Ptx was administered. Thus, IL-Ptx primes extinction learning regardless of the fear context in which the IL was initially activated. Second, activation of the IL must occur in conjunction with a fear context in order to enhance extinction; the extinction enhancing effect is not observable if IL-Ptx is administered in a neutral context. Finally, this extinction enhancing effect is specific to the IL for it does not occur if Ptx is injected into the prelimbic region (PL) of the mPFC. The results indicate a novel persisting control of fear induced by activation of the IL and suggest that IL activation induces changes in extinction-related circuitry that prime extinction learning.     

Estimating individual treatment effects from multiple-baseline data: A Monte Carlo study of multilevel-modeling approaches

While conducting intervention research, researchers and practitioners are often interested in how the intervention functions not only at the group level, but also at the individual level. One way to examine individual treatment effects is through multiple-baseline studies analyzed with multilevel modeling. This analysis allows for the construction of confidence intervals, which are strongly recommended in the reporting guidelines of the American Psychological Association. The purpose of this study was to examine the accuracy of confidence intervals of individual treatment effects obtained from multilevel modeling of multiple-baseline data. Monte Carlo methods were used to examine performance across conditions varying in the number of participants, the number of observations per participant, and the dependency of errors. The accuracy of the confidence intervals depended on the method used, with the greatest accuracy being obtained when multilevel modeling was coupled with the Kenward—Roger method of estimating degrees of freedom.     

Who do students with mild disabilities nominate as cool in inclusive general education classrooms?

Examined the nominations that elementary students with mild disabilities made for peers they perceived as cool. The total sample was comprised of 948 students (496 girls, 452 boys) from the metropolitan Chicago area and North Carolina and included 107 (11.3%) students with mild disabilities. Overall, students with mild disabilities nominated prosocial and athletic peers who affiliate with students with mild disabilities. However, aggressive boys who are central in the social network were highly likely to view aggressive peers as cool. Results are discussed in relation to implications for social interventions for students with mild disabilities.     

Suicidal behaviour and HIV disease: A case report

This case history describes the attempted suicide by jumping in front of a London Underground train of a man with advanced HIV disease. It illustrates the complex relationship between HIV disease and suicidal behaviour. Although the attempt was made by a man with AIDS, it is by no means evident that this disease was the sole or even the primary cause of his wish to die. This account is also interesting because of the unusual method used, the sudden onset of suicidal feelings and the patient's interpretation of the reason for his survival.     

Development of a measure of home-career conflict related to career motivation in college women

The purpose of this paper is to describe the development of a measure of Home-Career conflict (H-C) for college women. Data from two studies are presented. Subjects for the first study were college women enrolled in undergraduate psychology classes (N=163) at a large midwestern college. Subjects for the second study were fifty student teachers enrolled in Traditional female college majors (i.e., a majority are women) and fifty engineering students in Nontraditional female college majors (i.e., a majority are men). Findings from the first study indicated that high negative affect scores on the H-C measure were significantly (p<.05) related to low career motivation scores. Findings from the first study were used to revise the measure. Using discriminant analysis results from the second study obtained significantly different (p<.02) patterns of scores for Traditional college majors compared to Nontraditional college majors. Traditional majors wrote more stories depicting mothers as primarily homemakers and described more negative affect in their stories. Reliability estimates and validity data are provided. Suggestions for refinement of the measure are discussed as well as possible counseling uses.