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171.
Mershin A Pavlopoulos E Fitch O Braden BC Nanopoulos DV Skoulakis EM 《Learning & memory (Cold Spring Harbor, N.Y.)》2004,11(3):277-287
Mutations in the neuronal-specific microtubule-binding protein TAU are associated with several dementias and neurodegenerative diseases. However, the effects of elevated TAU accumulation on behavioral plasticity are unknown. We report that directed expression of wild-type vertebrate and Drosophila TAU in adult mushroom body neurons, centers for olfactory learning and memory in Drosophila, strongly compromised associative olfactory learning and memory, but olfactory conditioning-relevant osmotactic and mechanosensory responses remained intact. In addition, TAU accumulation in mushroom body neurons did not result in detectable neurodegeneration or premature death. Therefore, TAU-mediated structural or functional perturbation of the microtubular cytoskeleton in mushroom body neurons is likely causal of the behavioral deficit. These results indicate that behavioral plasticity decrements may be the earliest detectable manifestations of tauopathies. 相似文献
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Two auditory amplitude discrimination experiments were conducted using the same-different experimental design. Observer bias was manipulated, in the first experiment, by varying payoff matrices and, in the second, by varying prior probabilities of signal presentation. Five levels of bias manipulation and four levels of difficulty were employed in each experiment. Each observer received all combinations of bias manipulation and difficulty, but with only one of these combinations within each block of trials. Nine indices of bias were assessed by simultaneously fitting isosensitivity and isobias functions to the data and by fitting isobias functions only. Although none of the indices tested provided an exceptionally good fit to the data, two indices stood out from the rest. These were c*sd and ci, indices with isobias contours similar in shape to those for the c index derived from the yes-no task. 相似文献
174.
Dragana Ivkovich Kimberley L. Collins Carol O. Eckerman Norman A. Krasnegor & Mark E. Stanton 《Psychological science》1999,10(1):4-8
Abstract-Simple delay classical eyeblink conditioning, using a tone conditioned stimulus (CS) and airpuff unconditioned stimulus (US), was studied in cross-sectional samples of 4- and 5-month-old healthy, full-term infants. Infants received two identical training sessions, 1 week apart. At both ages, infants experiencing paired tones and air-puffs demonstrated successful conditioning over two sessions, relative to control subjects who had unpaired training. Conditioning was not evident, however, during the first session. Two additional groups of 5-month-olds received varied experiences during Session 1, either unpaired presentations of the CS and US or no stimulus exposure, fol-lowed by paired conditioning during Session 2. Results from these groups suggest that the higher level of conditioning observed following two sessions of paired conditioning was not the result of familiarity with the testing environment or the stimuli involved but, rather, the result of retention of associative learning not expressed during the first conditioning session. 相似文献
175.
Frank L. Collins Jr Lori A. Pbert Brian Sharp Stanley Smith Karen M. Gil J. Vernon Odom 《Behaviour research and therapy》1988,26(6):461-466
18 myopes and 18 emmetropes were randomly assigned in pairs to either Fading and Feedback training or a no-treatment control condition. The emmetropes were fitted with plus lenses equivalent to the spherical correction of the paired myope to simulate myopic visual acuity. Extensive visual acuity measures were obtained pre- and post-training. Data analyses indicated significant increases in recognition visual acuity for trained subjects, compared to no-treatment controls. The myopia/emmetropia variable did not interact with training even though there were noticably greater increases in visual acuity for trained myopes compared to the other conditions. Resolution visual acuity did not change as a function of training. These data are discussed in terms of their implications for better understanding the mechanisms responsible for visual acuity increases following behavioural training. 相似文献
176.
Parks Kathleen A. Miller Brenda A. Collins R. Lorraine Zetes-Zanatta Lisa 《Sex roles》1998,38(9-10):701-717
Fifty-two women bar drinkers participated infocus group discussions about women's reasons fordrinking, victimization experiences, and behaviors thatinfluence risk for victimization, in bars. The majority of the participants were White (67.3%),one-third were Black (30.8%), and one was NativeAmerican. Qualitative data analytic techniques were usedto assess the content of these discussions. Womendescribed distinct reasons for going to bars and providednumerous accounts of aggression they had witnessed orexperienced associated with this setting. Depictions ofphysical violence ranged from having an object thrown at them or being pushed, to accounts ofrape and attempted murder. These women also describedobservable changes in other women's behavior followingalcohol consumption, and how these behaviors increase risk for victimization in bars. The qualitativefindings are discussed in terms of what they tell usabout women bar drinkers and the insight theyprovide fordesigning future studies and interventions that focus on education and prevention. 相似文献
177.
A vignette methodology was used to examineperceptions of condom introducers on sixcondom-relevant,multi-item scales (Nice, Exciting, Sexually Attractive,Promiscuous, Good Relationship Partner,Unpersonable/Personable) in a university student sample of 133 MexicanAmericans and 110 Whites. Data were analyzed in a 2(gender of participant) ×2 (gender of condomintroducer) ×3 (low acculturated Mexican American,high acculturated Mexican American, White) ×2(presence/absence of close relationship theme) analysisof variance and covariance. Women rated condomintroducers significantly higher than men on the Nicescale, female condom introducers were rated significantly higherthan male condom introducers on the Nice scale, andcondom introducers who expressed a care andresponsibility theme while introducing a condom wererated significantly higher on the Nice scale than those whoexpressed no theme. The female condom introducer wasrated significantly higher than the male condomintroducer on the Exciting scale. Condom introducers whoexpressed a care and responsibility theme were ratedsignificantly higher than those who expressed no themeon the Good Relationship Partner scale. In a two-wayinteraction between gender of participant and gender of condom introducer, men rated the femalecondom introducer significantly higher than women on thePromiscuous scale. In another two-way interactionbetween gender of condom introducer and ethnicity, low acculturated Mexican Americans rated the femalecondom introducer significantly higher than the malecondom introducer on the Promiscuous scale. Lowacculturated Mexican Americans rated the condomintroducer significantly higher than Whites on theSexually Attractive scale. There were no significantmain or interaction effects of the independent variableson the Unpersonable/Personable scale. 相似文献
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