On the Ethics of Facial Transplantation Research

Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase.     

Resistance,reactance, and misinterpretation: Highlighting the challenge of persuading people with depression to seek help

Interventions that increase help‐seeking among people with depression have the potential to save lives. Several efforts have been impressively successful; however, research has also chronicled inconsistent results, with some endeavors indicating boomerang effects. The goal of the current analysis is to synthesize select findings from cognitive theorizing on depression with persuasion scholarship to explain how and why the combination of unfavorable attitudes toward help‐seeking, attitudes that are increasingly resistant to influence, psychological reactance, and cognitive errors can result in challenging responses to messages encouraging help‐seeking among people with depression. In addition, we highlight the importance of utilizing theory‐based approaches to circumvent resistance to persuasion and provide an explanation as to why the provision of immediate help‐seeking mechanisms could be a key aspect of successful intervention efforts. We also stress the importance of formative research and pilot testing, and warn against the potentially harmful error of assessing messages targeting people with depression on those without heightened levels of depressive symptomatology. Ideally, this effort will draw attention to the challenge of persuading people with depression to seek help and also motivate social psychologists to consider the ways they can use their craft to positively influence the health and well‐being of people with depression.     

Can Counterfactuals Really Be about Possible Worlds?

The standard view about counterfactuals is that a counterfactual (A > C) is true if and only if the A‐worlds most similar to the actual world @ are C‐worlds. I argue that the worlds conception of counterfactuals is wrong. I assume that counterfactuals have non‐trivial truth‐values under physical determinism. I show that the possible‐worlds approach cannot explain many embeddings of the form (P > (Q > R)), which intuitively are perfectly assertable, and which must be true if the contingent falsity of (Q > R) is to be explained. If (P > (Q > R)) has a backtracking reading then the contingent facts that (Q > R) needs to be true in the closest P‐worlds are absent. If (P > (Q > R)) has a forwardtracking reading, then the laws required by (Q > R) to be true in the closest P‐worlds will be absent, because they are violated in those worlds. Solutions like lossy laws or denial of embedding won't work. The only approach to counterfactuals that explains the embedding is a pragmatic metalinguistic approach in which the whole idea that counterfactuals are about a modal reality, be it abstract or concrete, is given up.     

The Role of Pre- and Postnatal Timing of Family Risk Factors on Child Behavior at 36 months

Children growing up in disharmonious families with anxious/depressed mothers are at risk for emotional and behavioral difficulties, however whether these associations reflect postnatal environment, prenatal exposure, or an overall liability is still unclear. This study used prospectively collected data from 24,259 participants of the Norwegian Mother and Child Cohort Study (MoBa). Mothers reported on anxiety/depression and family disharmony twice in pregnancy and twice post pregnancy, as well as on their child’s physical aggression and crying behavior at age 36 months. First, results from an autoregressive cross-lagged model showed a substantial stability in both maternal anxiety/depression and family disharmony from pregnancy to 18 months postnatal, but there was no indication that family disharmony led to maternal anxiety/depression, or the other way around. Second, structural equation models further suggests that the main risk derived from an overall liability, that is, a lasting effect of family risks that spanned the two time periods.     

The organization of narrative discourse in Lewy body spectrum disorder

Narrative discourse is an essential component of day-to-day communication, but little is known about narrative in Lewy body spectrum disorder (LBSD), including Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). We performed a detailed analysis of a semi-structured speech sample in 32 non-aphasic patients with LBSD, and we related their narrative impairments to gray matter (GM) atrophy using voxel-based morphometry. We found that patients with PDD and DLB have significant difficulty organizing their narrative speech. This was correlated with deficits on measures of executive functioning and speech fluency. Regression analyses associated this deficit with reduced cortical volume in inferior frontal and anterior cingulate regions. These findings are consistent with a model of narrative discourse that includes executive as well as language components and with an impairment of the organizational component of narrative discourse in patients with PDD and DLB.     

The neurocognition of conduct disorder behaviors: specificity to physical aggression and theft after controlling for ADHD symptoms

There is growing evidence that among the different conduct disorder (CD) behaviors, physical aggression, but not theft, links to low neurocognitive abilities. Specifically, physical aggression has consistently been found to be negatively related to neurocognitive abilities, whereas theft has been shown to be either positively or not related to neurocognition. The specificity of these links needs further examination because attention deficit hyperactivity disorder (ADHD) links to both physical aggression and neurocognitive variation. The development of self-reported physical aggression and theft, from age 11 to 17 years, was studied in a prospective at-risk male cohort via a dual process latent growth curve model. Seven neurocognitive tests at age 20 were regressed on the growth parameters of physical aggression and theft. The links between neurocognition and the growth parameters of physical aggression and theft were adjusted for ADHD symptoms at ages 11 and 15 (parent, child and teacher reports). Results indicated that verbal abilities were negatively related to physical aggression while they were positively associated with theft. However, inductive reasoning was negatively associated with increases in theft across adolescence. Symptoms of ADHD accounted for part of the neurocognitive test links with physical aggression but did not account for the associations with theft. These differences emphasize the importance of examining specific CD behaviors to better understand their neurodevelopmental mechanisms. They also suggest that youth who engage in different levels of physical aggression or theft behaviors may require different preventive and corrective interventions.     

From cognition’s location to the epistemology of its nature

One of the liveliest debates about cognition concerns whether our cognition sometimes extends beyond our brains and bodies. One party says Yes, another No. This paper shows that debate between these parties has been epistemologically confused and requires reorienting. Both parties frequently appeal to empirical considerations and to extra-empirical theoretical virtues to support claims about where cognition is. These things should constrain their claims, but cannot do all the work hoped. This is because of the overlooked fact, uncovered in this paper, that we could never distinguish the rival views empirically or by typical theoretical virtues. I show this by drawing on recent work on testing, predictive accuracy, and theoretical virtues. The recommendation to emerge is that we step back from debate about where cognition is, to the epistemology of what cognition is.     

Visual word recognition is accompanied by covert articulation: evidence for a speech-like phonological representation

Two lexical decision task (LDT) experiments examined whether visual word recognition involves the use of a speech-like phonological code that may be generated via covert articulation. In Experiment 1, each visual item was presented with an irrelevant spoken word (ISW) that was either phonologically identical, similar, or dissimilar to it. An ISW delayed classification of a visual word when the two were phonologically similar, and it delayed the classification of a pseudoword when it was identical to the base word from which the pseudoword was derived. In Experiment 2, a LDT was performed with and without articulatory suppression, and pseudowords consisted of regular pseudowords and pseudohomophones. Articulatory suppression decreased sound-specific ISW effects for words and regular pseudowords but not for pseudohomophones. These findings indicate that the processing of an orthographically legal letter sequence generally involves the specification of more than one sound code, one of which involves covert articulation.