fMRI of parents of children with Asperger Syndrome: a pilot study

BACKGROUND: People with autism or Asperger Syndrome (AS) show altered patterns of brain activity during visual search and emotion recognition tasks. Autism and AS are genetic conditions and parents may show the 'broader autism phenotype.' AIMS: (1) To test if parents of children with AS show atypical brain activity during a visual search and an empathy task; (2) to test for sex differences during these tasks at the neural level; (3) to test if parents of children with autism are hyper-masculinized, as might be predicted by the 'extreme male brain' theory. METHOD: We used fMRI during a visual search task (the Embedded Figures Test (EFT)) and an emotion recognition test (the 'Reading the Mind in the Eyes' (or Eyes) test). SAMPLE: Twelve parents of children with AS, vs. 12 sex-matched controls. DESIGN: Factorial analysis was used to map main effects of sex, group (parents vs. controls), and sexxgroup interaction on brain function. An ordinal ANOVA also tested for regions of brain activity where females>males>fathers=mothers, to test for parental hyper-masculinization. RESULTS ON EFT TASK: Female controls showed more activity in extrastriate cortex than male controls, and both mothers and fathers showed even less activity in this area than sex-matched controls. There were no differences in group activation between mothers and fathers of children with AS. The ordinal ANOVA identified two specific regions in visual cortex (right and left, respectively) that showed the pattern Females>Males>Fathers=Mothers, both in BA 19. RESULTS ON EYES TASK: Male controls showed more activity in the left inferior frontal gyrus than female controls, and both mothers and fathers showed even more activity in this area compared to sex-matched controls. Female controls showed greater bilateral inferior frontal activation than males. This was not seen when comparing mothers to males, or mothers to fathers. The ordinal ANOVA identified two specific regions that showed the pattern Females>Males>Mothers=Fathers: left medial temporal gyrus (BA 21) and left dorsolateral prefrontal cortex (BA 44). CONCLUSIONS: Parents of children with AS show atypical brain function during both visual search and emotion recognition, in the direction of hyper-masculinization of the brain. Because of the small sample size, and lack of age-matching between parents and controls, such results constitute a pilot study that needs replicating with larger samples.     

Suppression of emotional and nonemotional content in memory: effects of repetition on cognitive control

Two experiments utilized a think/no-think paradigm to examine whether cognitive control of memories differs depending on whether they contain information with negative or neutral emotional content. During a training phase, participants learned face-word pairs (Experiment 1) or face-picture pairs (Experiment 2). In a subsequent experimental phase, participants were shown faces and told to think of the items paired with some of the faces and to try not to think of the items paired with other faces. Finally, in a test phase, participants were again shown each face and asked to recall the item with which it had been paired previously. Results for both verbal (Experiment 1) and nonverbal (Experiment 2) items indicated that the facilitatory and inhibitory influences of cognitive control were larger for negative than neutral items.     

Episodic chasing in pathological gamblers using the Iowa gambling task

"Chasing ones losses" is a key symptom among pathological gamblers (PGs). This study focuses on quantitative differences in episodic chasing (i.e., sequences of disadvantageous decisions within a single gambling session) between PGs and non-pathological gamblers (NPGs). We compared 61 PGs and 39 NPGs on the Iowa Gambling Task (IGT) and the Zuckerman Sensation Seeking Scale (SSS). The PGs showed significantly more chasing and had significantly poorer decision-making strategies than NPGs, particularly among males (F = 4.52, p < 0.05). Random players were significantly less sensation seeking than advantageous and disadvantageous (i.e., chasing) players, but there was no interaction with group or gender. The results suggest that quantifiable within-session gambling behavior holds important implications for detecting underlying vulnerabilities to gambling pathology.     

Retrieval practice benefits memory precision

ABSTRACT

Although previous research on retrieval practice (RP) has predominantly featured stimuli with discrete right-or-wrong answers, continuous measures offer potentially greater sensitivity in assessing the effects of RP on memory precision. The present study used a colour gradient (125 points ranging from magenta to yellow) as a continuous response variable. The colours of different images were learned through either RP or restudy and either one or three cycles of practice after initial study. On a delayed final test, participants’ memory was assessed for each item’s colour. Participants also created per-item intervals representing the region where they believed the correct colour most likely to have been. We found that repeated rounds of RP enhanced the correspondence between responses and the correct colour. In addition, RP led to participants creating more accurate (correct answers were more likely to be within the participant-specified intervals) and more precise (narrower) intervals relative to restudy, suggesting that RP enhances the precision of memories.     

Pedagogy for Inter‐Religious Education

Inter‐religious education has become a major concern as globalization proceeds. To develop a satisfactory model for it remains a challenge. This article proposes a paradigm based on the notion of self‐transcendence as articulated by the philosopher‐theologian, Bernard Lonergan. The approach provides a standpoint where the learner achieves a level of freedom by which he/she is enabled to decide responsibly what religious or non‐religious viewpoint to adopt.     

Spinoza's environmental ethics

The paper explores an apparent tension in Spinoza's thought between his treatment of man as part of nature, with no specially privileged position within it; and his treatment of morality as circumscribed by what is good for human beings. These two themes, it is argued, are in fact interconnected in Spinoza's thought. The paper goes on to consider some possible responses, from a contemporary standpoint, to Spinoza's rejection of animal rights. Finally, it is argued that the apparent tension in Spinoza's thought becomes more understandable in the light of his treatment of the importance of truth to human beings; and that this throws into relief some puzzling features of some contemporary formulations of the theme of man as part of nature.     

The Group Psychotherapy Literature: 1976

This paper reviews and critiques the literature on countertransference (CT) in group psychotherapy. The literature review is organized within a framework that calls attention to the origins, triggers, manifestations, and effects of CT in groups, as well as CT management factors. An overriding critique is that the present literature lacks a research foundation of any kind. An argument is made for beginning research in this domain, and guidelines for doing so are presented.     

Replacement in Logic

We study a range of issues connected with the idea of replacing one formula by another in a fixed (linguistic) context. The replacement core of a consequence relation ? is the relation holding between a set of formulas {A ₁, ..., A _m , ...} and a formula B when for every context C(·), we have C(A ₁), ..., C(A _m ), ...???C(B). Section 1 looks at some differences between which inferences are lost on passing to the replacement cores of the classical and intuitionistic consequence relations. For example, we find that while the inference from A and B to $A \land B$ , sanctioned by both these initial consequence relations, is retained on passage to the replacement core in the classical case, it is lost in the intuitionistic case. Further discussion of these two (and some other) logics occupies Sections 3 and 4. Section 2 looks at the m?=?1 case, describing A as replaceable by B according to ? when B is a consequence of A by the replacement core of ?, and inquiring as to which choices of ? render this induced replaceability relation symmetric. Section 5 investigates further conceptual refinements— such as a contrast between horizontal and vertical replaceability—suggested by some work of R. B. Angell and R. Harrop (and a comment on the latter by T. J. Smiley) in the 1950s and 1960s. Appendix 1 examines a related aspect of term-for-term replacement in connection with identity in predicate logic. Appendix 2 is a repository for proofs which would otherwise clutter up Section 3.